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- Imran, Muhammad
(författare)
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Energy Efficient and Programmable Architecture for Wireless Vision Sensor Node
- 2013
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Wireless Vision Sensor Networks (WVSNs) is an emerging field which has attracted a number of potential applications because of smaller per node cost, ease of deployment, scalability and low power stand alone solutions. WVSNs consist of a number of wireless Vision Sensor Nodes (VSNs). VSN has limited resources such as embedded processing platform, power supply, wireless radio and memory. In the presence of these limited resources, a VSN is expected to perform complex vision tasks for a long duration of time without battery replacement/recharging. Currently, reduction of processing and communication energy consumptions have been major challenges for battery operated VSNs. Another challenge is to propose generic solutions for a VSN so as to make these solutions suitable for a number of applications.To meet these challenges, this thesis focuses on energy efficient and programmable VSN architecture for machine vision systems which can classify objects based on binary data. In order to facilitate generic solutions, a taxonomy has been developed together with a complexity model which can be used for systems’ classification and comparison without the need for actual implementation. The proposed VSN architecture is based on tasks partitioning between a VSN and a server as well as tasks partitioning locally on the node between software and hardware platforms. In relation to tasks partitioning, the effect on processing, communication energy consumptions, design complexity and lifetime has been investigated.The investigation shows that the strategy, in which front end tasks up to segmentation, accompanied by a bi-level coding, are implemented on Field Programmable Platform (FPGA) with small sleep power, offers a generalized low complexity and energy efficient VSN architecture. The implementation of data intensive front end tasks on hardware reconfigurable platform reduces processing energy. However, there is a scope for reducing communication energy, related to output data. This thesis also explores data reduction techniques including image coding, region of interest coding and change coding which reduces output data significantly.For proof of concept, VSN architecture together with tasks partitioning, bi-level video coding, duty cycling and low complexity background subtraction technique has been implemented on real hardware and functionality has been verified for four applications including particle detection system, remote meter reading, bird detection and people counting. The results based on measured energy values shows that, depending on the application, the energy consumption can be reduced by a factor of approximately 1.5 up to 376 as compared to currently published VSNs. The lifetime based on measured energy values showed that for a sample period of 5 minutes, VSN can achieve 3.2 years lifetime with a battery of 37.44 kJ energy. In addition to this, proposed VSN offers generic architecture with smaller design complexity on hardware reconfigurable platform and offers easy adaptation for a number of applications as compared to published systems.
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| 2. |
- Piazza, I, et al.
(författare)
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A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes
- 2020
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Ingår i: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 4200-
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Tidskriftsartikel (refereegranskat)abstract
- Chemoproteomics is a key technology to characterize the mode of action of drugs, as it directly identifies the protein targets of bioactive compounds and aids in the development of optimized small-molecule compounds. Current approaches cannot identify the protein targets of a compound and also detect the interaction surfaces between ligands and protein targets without prior labeling or modification. To address this limitation, we here develop LiP-Quant, a drug target deconvolution pipeline based on limited proteolysis coupled with mass spectrometry that works across species, including in human cells. We use machine learning to discern features indicative of drug binding and integrate them into a single score to identify protein targets of small molecules and approximate their binding sites. We demonstrate drug target identification across compound classes, including drugs targeting kinases, phosphatases and membrane proteins. LiP-Quant estimates the half maximal effective concentration of compound binding sites in whole cell lysates, correctly discriminating drug binding to homologous proteins and identifying the so far unknown targets of a fungicide research compound.
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