| 1. |
- Volpe, Giovanni, 1979, et al.
(författare)
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Roadmap for optical tweezers
- 2023
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Ingår i: Journal of Physics-Photonics. - : IOP Publishing. - 2515-7647. ; 5:2
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Tidskriftsartikel (refereegranskat)abstract
- Optical tweezers are tools made of light that enable contactless pushing, trapping, and manipulation of objects, ranging from atoms to space light sails. Since the pioneering work by Arthur Ashkin in the 1970s, optical tweezers have evolved into sophisticated instruments and have been employed in a broad range of applications in the life sciences, physics, and engineering. These include accurate force and torque measurement at the femtonewton level, microrheology of complex fluids, single micro- and nano-particle spectroscopy, single-cell analysis, and statistical-physics experiments. This roadmap provides insights into current investigations involving optical forces and optical tweezers from their theoretical foundations to designs and setups. It also offers perspectives for applications to a wide range of research fields, from biophysics to space exploration.
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| 2. |
- Gieseler, J., et al.
(författare)
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Optical tweezers - from calibration to applications: a tutorial
- 2021
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Ingår i: Advances in Optics and Photonics. - : Optica Publishing Group. - 1943-8206. ; 13:1, s. 74-241
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Tidskriftsartikel (refereegranskat)abstract
- Since their invention in 1986 by Arthur Ashkin and colleagues, optical tweezers have become an essential tool in several fields of physics, spectroscopy, biology, nanotechnology, and thermodynamics. In this tutorial, we provide a primer on how to calibrate optical tweezers and how to use them for advanced applications. After a brief general introduction on optical tweezers, we focus on describing and comparing the various available calibration techniques. Then, we discuss some cutting-edge applications of optical tweezers in a liquid medium, namely, to study single-molecule and single-cell mechanics, microrheology, colloidal interactions, statistical physics, and transport phenomena. Finally, we consider optical tweezers in vacuum, where the absence of a viscous medium offers vastly different dynamics and presents new challenges. We conclude with some perspectives for the field and the future applications of optical tweezers. This tutorial provides both a step-by-step guide ideal for non-specialists entering the field and a comprehensive manual of advanced techniques useful for expert practitioners. All of the examples are complemented by the sample data and software necessary to reproduce them. (C) 2021 Optical Society of America.
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| 3. |
- Rico-Pasto, M., et al.
(författare)
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Dissipation Reduction and Information-to-Measurement Conversion in DNA Pulling Experiments with Feedback Protocols
- 2021
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Ingår i: Physical Review X. - 2160-3308. ; 11:3
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Tidskriftsartikel (refereegranskat)abstract
- Information-to-energy conversion with feedback measurement stands as one of the most intriguing aspects of the thermodynamics of information in the nanoscale. To date, experiments have focused on feedback protocols for work extraction. Here we address the novel case of dissipation reduction in nonequilibrium systems with feedback. We perform pulling experiments on DNA hairpins with optical tweezers, with a general feedback protocol based on multiple measurements that includes either discrete-time or continuous-time feedback. While feedback can reduce dissipation, it remains unanswered whether it also improves free-energy determination (information-to-measurement conversion). We define thermodynamic information as the natural logarithm of the feedback efficacy, a quantitative measure of the efficiency of information-to-energy and information-to-measurement conversion in feedback protocols. We find that discrete- and continuous-time feedback reduces dissipation by roughly kBT without improvement in free-energy determination. Remarkably, a feedback strategy (defined as a correlated sequence of feedback protocols) further reduces dissipation, enhancing information-to-measurement efficiency. Our study underlines the role of temporal correlations to develop feedback strategies for efficient information-to-measurement conversion in small systems.
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