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- Block, Keith I., et al.
(författare)
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Designing a broad-spectrum integrative approach for cancer prevention and treatment
- 2015
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Ingår i: Seminars in Cancer Biology. - : Academic Press. - 1044-579X .- 1096-3650. ; 35, s. S276-S304
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Forskningsöversikt (refereegranskat)abstract
- Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted). To address these limitations, an international task force of 180 scientists was assembled to explore the concept of a low-toxicity "broadspectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspects of relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a wide range of high-priority targets (74 in total) that could be modified to improve patient outcomes. For these targets, corresponding low-toxicity therapeutic approaches were then suggested, many of which were phytochemicals. Proposed actions on each target and all of the approaches were further reviewed for known effects on other hallmark areas and the tumor microenvironment Potential contrary or procarcinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixed evidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of the relationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. This novel approach has potential to be relatively inexpensive, it should help us address stages and types of cancer that lack conventional treatment, and it may reduce relapse risks. A proposed agenda for future research is offered. (C) 2015 The Authors. Published by Elsevier Ltd.
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| 2. |
- Holmström, Jonny, 1968-
(författare)
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Information system and organization as multipurpose network
- 2000
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Information systems (IS) are widely acknowledged to be central for contemporary organizations. Along with the increasing importance of new IS in organizations, a school of thought has developed over the last few years that claims that IS and organizations mutually shape each other. While new IS shape organizational structure and behavior, the actual role and importance of IS in organizations is largely dependent on the organizational setting. However, questions of how IS and organizations mutually shape each other have remained largely unexplored. The purpose of this thesis is to create better understanding of the design and use of IS in an organizational context. Actor-network theory (ANT) is used as a theoretical perspective to gain an understanding of how IS and organization influence each other. An interpretive case study approach was used for data collection. The case study was conducted in the municipal organization of Umeå, Sweden, over a period 36 months that covered the design process and use of a new IS. Semi-structured interviews, participant observations and document analysis were used as data collection techniques. The findings indicate that the municipal organization became intertwined with technology by mobilizing a significant amount of allies in the IS adaption process. It was also found that the character of the IS in the organization was multi-faceted, and there were different versions of the application available for different actors. A new organizational behavior was established as a result of the design and use of the IS. While the new IS contributed to making more available the complicated financial aspects of the municipality, it also contributed in reinforcing a certain view on decision-making that was focused on organizational resources rather than on organizational objectives. The organizational changes that took place were of a constant nature, and there was no closure of the change processes as new issues continuously surfaced that needed attention. The concept of evolving multi-purpose networks is coined to describe and analyze the character of the technology dependent organization. The concept of negotiation loop is coined to describe and analyze the processes of IS adaption, where the role and meaning of the IS changes as new actors are enrolled to the network. An evolving multipurpose network is changeful as negotiation loops continue after the IS is established in the organization. The notation of evolving multipurpose networks is meant to stimulate reflection both for researchers and practitioners, underscoring the negotiated character of IS in organizations. It is meant to allow a better understanding for how the design and use of IS in an organizational context is a process of mutual influence between the IS and organization.
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| 5. |
- Robey, Daniel, et al.
(författare)
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Transforming municipal governance in global context : a case study of the dialectics of social change
- 2001
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Ingår i: Journal of Global Information Technology Management. - 1097-198X. ; 4:4, s. 19-31
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents a social analysis of the development and use of information technology to support the governance process in the municipal organization of Umeå, Sweden. The technology was intended to monitor and scrutinize organizational activities by paying closer attention to the resources required for public programs. Through its use, municipal managers hoped to increase the visibility of the economic consequences of decisions to fund particular social programs. In this paper, we analyze the implementation of the system at the organizational and institutional levels of social analyses. Employing a dialectic approach, which examines forces promoting and opposing social change, we explain how the tool was easily implemented in the organization but opposed by the community’s citizens. Although the information system reinforced a new economic discourse and helped to make organizational members more accountable for their actions, the citizens protested the effects of the new economic discourse. By focusing simultaneously upon organizational and institutional influences, we can understand more completely how global pressures translate into organizational and societal change.
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