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Sökning: WFRF:(Rodina Yulia)

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1.
  • Bastard, Paul, et al. (författare)
  • Preexisting autoantibodies to type I IFNs underlie critical COVID-19 pneumonia in patients with APS-1.
  • 2021
  • Ingår i: The Journal of experimental medicine. - 1540-9538. ; 218:7
  • Tidskriftsartikel (refereegranskat)abstract
    • Patients with biallelic loss-of-function variants of AIRE suffer from autoimmune polyendocrine syndrome type-1 (APS-1) and produce a broad range of autoantibodies (auto-Abs), including circulating auto-Abs neutralizing most type I interferons (IFNs). These auto-Abs were recently reported to account for at least 10% of cases of life-threatening COVID-19 pneumonia in the general population. We report 22 APS-1 patients from 21 kindreds in seven countries, aged between 8 and 48 yr and infected with SARS-CoV-2 since February 2020. The 21 patients tested had auto-Abs neutralizing IFN-α subtypes and/or IFN-ω; one had anti-IFN-β and another anti-IFN-ε, but none had anti-IFN-κ. Strikingly, 19 patients (86%) were hospitalized for COVID-19 pneumonia, including 15 (68%) admitted to an intensive care unit, 11 (50%) who required mechanical ventilation, and four (18%) who died. Ambulatory disease in three patients (14%) was possibly accounted for by prior or early specific interventions. Preexisting auto-Abs neutralizing type I IFNs in APS-1 patients confer a very high risk of life-threatening COVID-19 pneumonia at any age.
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2.
  • Gagarina, Natalia, et al. (författare)
  • How oral texts are organized in monolingual and heritage Russian : evidence from six countries
  • 2021
  • Ingår i: Language impairment in multilingual settings. - Amsterdam : John Benjamins Publishing Company. - 9789027209795 ; , s. 47-76
  • Bokkapitel (refereegranskat)abstract
    • The present study examines narrative macrostructure, measured as Story Structure (SS) and Story Complexity (SC), in bilinguals speaking Russian as their home/heritage language (L1) and exposed to different societal languages (L2), while focusing on the effects of different L2s, bilingualism, and episodic structure and compares it to monolingual Russian. The Multilingual Assessment Instrument for Narratives (LITMUS-MAIN) was used to elicit narratives in L1/Russian from 162 L2 Finnish, German, Hebrew, Norwegian, or Swedish bilinguals (4- and 6-year-olds) and 21 monolingual Russian children (4-year-olds). Age-matched bilinguals showed similarity in SS (except for children speaking L2 German or Hebrew) and SC. Monolinguals (age range 50–59 months) outperformed younger bilinguals (age range 48–59 months) in SS and SC but performed similarly to older bilinguals (age range 66–83 months). Fine-grained analysis revealed that a well-formed episode might include an Attempt-Outcome sequence combined with Internal States (and not only Goal-Attempt-Outcome) and that children are sensitive to events depicted in each episode. The findings show some evidence for the universality of macrostructure and provide insight into macrostructural knowledge at the episode level. The results are discussed within the theoretical model of multidimensional text organization.
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