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- Mock, Thomas, et al.
(författare)
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Multiomics in the central Arctic Ocean for benchmarking biodiversity change
- 2022
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Ingår i: PLoS biology. - : Public Library of Science (PLoS). - 1544-9173 .- 1545-7885. ; 20:10
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Tidskriftsartikel (refereegranskat)abstract
- Multiomics approaches need to be applied in the central Arctic Ocean to benchmark biodiversity change and to identify novel species and their genes. As part of MOSAiC, EcoOmics will therefore be essential for conservation and sustainable bioprospecting in one of the least explored ecosystems on Earth.
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- Gunbeyaz, Sefer Anil, et al.
(författare)
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Workers' exposure to dust and potentially toxic elements during steel cutting in two ship dismantling cases
- 2023
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Ingår i: Ocean Engineering. - : Elsevier Ltd. - 0029-8018 .- 1873-5258. ; 270
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Tidskriftsartikel (refereegranskat)abstract
- Ship dismantling is the recommended recycling solution for the end of a ship's life, but the process is not free of occupational risk. Despite proper regulations, there are underlying chemical and physical hazards, mainly due to the cutting of steel parts, which is the core of the recycling process. The overall aim of this research study is to determine, in two case study examples, the ship recycling workers' potential occupational exposure by inhalation of chemical agents generated by the torch cutting process of coated and de-coated steel. This was carried out specifically through (i) monitoring and measuring ship recycling workers' local environment for the inhalable (total dust) and respirable (fine dust) fractions during their working operations, (ii) analysing the heavy metal content of the dust and (iii) calculating and comparing this against occupational exposure limits, (iv) comparing de-coating operations with cutting of coated and de-coated steel. Results of this study show that without further mitigation workers involved in torch cutting processes are at high risk of exposure to heavy metals by inhalation as these are exceeding the norms defined by regulatory bodies. © 2023 The Authors
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- Terwee, Caroline B., et al.
(författare)
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Patient-reported outcomes for people with diabetes : what and how to measure? A narrative review
- 2023
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Ingår i: Diabetologia. - : Springer. - 0012-186X .- 1432-0428. ; 66:8, s. 1357-1377
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Forskningsöversikt (refereegranskat)abstract
- Patient-reported outcomes (PROs) are valuable for shared decision making and research. Patient-reported outcome measures (PROMs) are questionnaires used to measure PROs, such as health-related quality of life (HRQL). Although core outcome sets for trials and clinical practice have been developed separately, they, as well as other initiatives, recommend different PROs and PROMs. In research and clinical practice, different PROMs are used (some generic, some disease-specific), which measure many different things. This is a threat to the validity of research and clinical findings in the field of diabetes. In this narrative review, we aim to provide recommendations for the selection of relevant PROs and psychometrically sound PROMs for people with diabetes for use in clinical practice and research. Based on a general conceptual framework of PROs, we suggest that relevant PROs to measure in people with diabetes are: disease-specific symptoms (e.g. worries about hypoglycaemia and diabetes distress), general symptoms (e.g. fatigue and depression), functional status, general health perceptions and overall quality of life. Generic PROMs such as the 36-Item Short Form Health Survey (SF-36), WHO Disability Assessment Schedule (WHODAS 2.0), or Patient-Reported Outcomes Measurement Information System (PROMIS) measures could be considered to measure commonly relevant PROs, supplemented with disease-specific PROMs where needed. However, none of the existing diabetes-specific PROM scales has been sufficiently validated, although the Diabetes Symptom Self-Care Inventory (DSSCI) for measuring diabetes-specific symptoms and the Diabetes Distress Scale (DDS) and Problem Areas in Diabetes (PAID) for measuring distress showed sufficient content validity. Standardisation and use of relevant PROs and psychometrically sound PROMs can help inform people with diabetes about the expected course of disease and treatment, for shared decision making, to monitor outcomes and to improve healthcare. We recommend further validation studies of diabetes-specific PROMs that have sufficient content validity for measuring disease-specific symptoms and consider generic item banks developed based on item response theory for measuring commonly relevant PROs.
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