| 1. |
- Mauritsen, Thorsten, et al.
(författare)
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Developments in the MPI-M Earth System Model version 1.2 (MPI-ESM1.2) and Its Response to Increasing CO2
- 2019
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Ingår i: Journal of Advances in Modeling Earth Systems. - 1942-2466. ; 11:4, s. 998-1038
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Tidskriftsartikel (refereegranskat)abstract
- A new release of the Max Planck Institute for Meteorology Earth System Model version 1.2 (MPI-ESM1.2) is presented. The development focused on correcting errors in and improving the physical processes representation, as well as improving the computational performance, versatility, and overall user friendliness. In addition to new radiation and aerosol parameterizations of the atmosphere, several relatively large, but partly compensating, coding errors in the model's cloud, convection, and turbulence parameterizations were corrected. The representation of land processes was refined by introducing a multilayer soil hydrology scheme, extending the land biogeochemistry to include the nitrogen cycle, replacing the soil and litter decomposition model and improving the representation of wildfires. The ocean biogeochemistry now represents cyanobacteria prognostically in order to capture the response of nitrogen fixation to changing climate conditions and further includes improved detritus settling and numerous other refinements. As something new, in addition to limiting drift and minimizing certain biases, the instrumental record warming was explicitly taken into account during the tuning process. To this end, a very high climate sensitivity of around 7 K caused by low-level clouds in the tropics as found in an intermediate model version was addressed, as it was not deemed possible to match observed warming otherwise. As a result, the model has a climate sensitivity to a doubling of CO2 over preindustrial conditions of 2.77 K, maintaining the previously identified highly nonlinear global mean response to increasing CO2 forcing, which nonetheless can be represented by a simple two-layer model.
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| 2. |
- Rohrschneider, Tim, et al.
(författare)
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On simple representations of the climate response to external radiative forcing
- 2019
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Ingår i: Climate Dynamics. - : Springer Science and Business Media LLC. - 0930-7575 .- 1432-0894. ; 53:5-6, s. 3131-3145
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Tidskriftsartikel (refereegranskat)abstract
- Global warming in response to external radiative forcing is determined by the feedback of the climate system. Recent studies have suggested that simple mathematical models incorporating a radiative response which is related to upper- and deep-ocean disequilibrium (ocean heat uptake efficacy), inhomogeneous patterns of surface warming and radiative feedbacks (pattern effect), or an explicit dependence of the strength of radiative feedbacks on surface temperature change (feedback temperature dependence) may explain the climate response in atmosphere-ocean coupled general circulation models (AOGCMs) or can be useful for interpreting the instrumental record. We analyze a two-layer model with an ocean heat transport efficacy, a two-region model with region specific heat capacities and radiative responses; a one-layer model with a temperature dependent feedback; and a model which combines elements of the two-layer/region models and the state-dependent feedback parameter. We show that, from the perspective of the globally averaged surface temperature and radiative imbalance, the two-region and two-layer models are equivalent. State-dependence of the feedback parameter introduces a nonlinearity in the system which makes the adjustment timescales forcing-dependent. Neither the linear two-region/layer models, nor the state-dependent feedback model adequately describes the behavior of complex climate models. The model which combines elements of both can adequately describe the response of more comprehensive models but may require more experimental input than is available from single forcing realizations.
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| 3. |
- Weisschuh, Nicole, et al.
(författare)
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Mutation Detection in Patients with Retinal Dystrophies Using Targeted Next Generation Sequencing.
- 2016
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Ingår i: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- Retinal dystrophies (RD) constitute a group of blinding diseases that are characterized by clinical variability and pronounced genetic heterogeneity. The different nonsyndromic and syndromic forms of RD can be attributed to mutations in more than 200 genes. Consequently, next generation sequencing (NGS) technologies are among the most promising approaches to identify mutations in RD. We screened a large cohort of patients comprising 89 independent cases and families with various subforms of RD applying different NGS platforms. While mutation screening in 50 cases was performed using a RD gene capture panel, 47 cases were analyzed using whole exome sequencing. One family was analyzed using whole genome sequencing. A detection rate of 61% was achieved including mutations in 34 known and two novel RD genes. A total of 69 distinct mutations were identified, including 39 novel mutations. Notably, genetic findings in several families were not consistent with the initial clinical diagnosis. Clinical reassessment resulted in refinement of the clinical diagnosis in some of these families and confirmed the broad clinical spectrum associated with mutations in RD genes.
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