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| 2. |
- Sinibaldi, Giorgia, et al.
(författare)
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Aeroacoustics and aerodynamics of impinging supersonic jets : Analysis of the screech tones
- 2013
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Ingår i: Physics of fluids. - : American Institute of Physics (AIP). - 1070-6631 .- 1089-7666. ; 25:8
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Tidskriftsartikel (refereegranskat)abstract
- The interaction between acoustics and aerodynamics of a supersonic jet is an actual fundamental topic which has been a matter of discussion in the last decades. The present paper is devoted to the experimental analysis of free and impinging jets with particular attention on the effect of an impinging surface on screech tones. The acoustics is studied using free-field microphones, while Particle Image Velocimetry is used to investigate the velocity field. The analysis of acquired data allowed to verify and explain the coupling between acoustic discrete tones and mean and fluctuating flow velocities.
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| 3. |
- Sinibaldi, Giorgia, et al.
(författare)
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Analysis of the Characteristic Acoustic Tones of an Impinging Jet
- 2013
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Ingår i: 19th AIAA/CEAS Aeroacoustics Conference. - Reston, Virginia : American Institute of Aeronautics and Astronautics. - 9781624102134
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Konferensbidrag (refereegranskat)abstract
- The acoustic emission of a supersonic jet is an interesting and fundamental issue due to the several technological applications and the diverse physical aspects to be still clarified. An experimental analysis of the characteristic acoustic tones of a supersonic impinging jet has been carried out with a particular attention on the effect of the nozzle pressure ratio and the distance of the impinging surface. The screech tones, typical of an imperfectly expanded supersonic free jet, have been first investigated to have an idea of the deflection from the free jet behavior due to the impinging surface. Then the analysis has been focused on smaller distances of the impinging plate from the jet exit to evaluate the behavior of the impinging tones. The difference between screech and impinging tones, due to the different interactions in the generating feedback mechanism, has been observed.
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| 4. |
- Cavarretta, Elena, et al.
(författare)
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The role of echocardiography in sports cardiology : An expert opinion statement of the Italian Society of Sports Cardiology (SIC sport)
- 2024
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Ingår i: International Journal of Cardiology. - 0167-5273. ; 410
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Tidskriftsartikel (refereegranskat)abstract
- Transthoracic echocardiography (TTE) is routinely required during pre-participation screening in the presence of symptoms, family history of sudden cardiac death or cardiomyopathies <40-year-old, murmurs, abnormal ECG findings or in the follow-up of athletes with a history of cardiovascular disease (CVD). TTE is a cost-effective first-line imaging modality to evaluate the cardiac remodeling due to long-term, intense training, previously known as the athlete's heart, and to rule out the presence of conditions at risk of sudden cardiac death, including cardiomyopathies, coronary artery anomalies, congenital, aortic and heart valve diseases. Moreover, TTE is useful for distinguishing physiological cardiac adaptations during intense exercise from pathological behavior due to an underlying CVD. In this expert opinion statement endorsed by the Italian Society of Sports Cardiology, we discussed common clinical scenarios where a TTE is required and conditions falling in the grey zone between the athlete's heart and underlying cardiomyopathies or other CVD. In addition, we propose a minimum dataset that should be included in the report for the most common indications of TTE in sports cardiology clinical practice.
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| 5. |
- Dionysopoulou, Stavroula, et al.
(författare)
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Topically Administered NOX4 Inhibitor, GLX7013114, Is Efficacious in Treating the Early Pathological Events of Diabetic Retinopathy
- 2023
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Ingår i: Diabetes. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 72:5, s. 638-652
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Tidskriftsartikel (refereegranskat)abstract
- NADPH oxidases (NOXs) are major players in generating reactive oxygen species (ROS) and are implicated in various neurodegenerative ocular pathologies. The aim of this study was to investigate the role of a NOX4 inhibitor (GLX7013114) in two in vivo, experimental streptozotocin (STZ) paradigms depicting the early events of diabetic retinopathy (DR). Animals in the diabetic treated group received GLX7013114 topically (20 mu L/eye, 10 mg/mL, once daily) for 14 days (paradigm A: preventive) and 7 days (paradigm B: treated) at 48 h and 4 weeks after STZ injection, respectively. Several methodologies were used (immunohistochemistry, Western blot, real-time PCR, ELISA, pattern electroretinography [PERG]) to assess the diabetes-induced early events of DR, namely oxidative stress, neurodegeneration, and neuroinflammation, and the effect of GLX7013114 on the diabetic insults. GLX7013114, administered as eye drops (paradigms A and B), was beneficial in treating the oxidative nitrative stress, activation of caspase-3 and micro- and macroglia, and attenuation of neuronal markers. It also attenuated the diabetes-induced increase in vascular endothelial growth factor, Evans blue dye leakage, and proinflammatory cytokine (TNF-alpha protein, IL-1 beta/IL-6 mRNA) levels. PERG amplitude values suggested that GLX7013114 protected retinal ganglion cell function (paradigm B). This study provides new findings regarding the pharmacological profile of the novel NOX4 inhibitor GLX7013114 as a promising therapeutic candidate for the treatment of the early stage of DR.
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| 6. |
- Franchini, Mariagrazia, et al.
(författare)
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The Gaia-ESO Survey : Carbon Abundance in the Galactic Thin and Thick Disks
- 2020
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Ingår i: Astrophysical Journal. - : IOP PUBLISHING LTD. - 0004-637X .- 1538-4357. ; 888:2
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Tidskriftsartikel (refereegranskat)abstract
- This paper focuses on carbon, which is one of the most abundant elements in the universe and is of high importance in the field of nucleosynthesis and galactic and stellar evolution. The origin of carbon and the relative importance of massive and low- to intermediate-mass stars in producing it is still a matter of debate. We aim at better understanding the origin of carbon by studying the trends of [C/H], [C/Fe], and [C/Mg] versus [Fe/H] and [Mg/H] for 2133 FGK dwarf stars from the fifth Gaia-ESO Survey internal data release (GES iDR5). The availability of accurate parallaxes and proper motions from Gaia DR2 and radial velocities from GES iDR5 allows us to compute Galactic velocities, orbits, absolute magnitudes, and, for 1751 stars, Bayesian-derived ages. Three different selection methodologies have been adopted to discriminate between thin- and thick-disk stars. In all the cases, the two stellar groups show different [C/H], [C/Fe], and [C/Mg] and span different age intervals, with the thick-disk stars being, on average, older than the thin-disk ones. The behaviors of [C/H], [C/Fe], and [C/Mg] versus [Fe/H], [Mg/H], and age all suggest that C is primarily produced in massive stars. The increase of [C/Mg] for young thin-disk stars indicates a contribution from low-mass stars or the increased C production from massive stars at high metallicities due to the enhanced mass loss. The analysis of the orbital parameters R-med and supports an "inside-out" and "upside-down" formation scenario for the disks of the Milky Way.
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| 7. |
- Franchini, Mariagrazia, et al.
(författare)
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The Gaia-ESO Survey : Oxygen Abundance in the Galactic Thin and Thick Disks*
- 2021
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Ingår i: Astronomical Journal. - : Institute of Physics Publishing (IOPP). - 0004-6256 .- 1538-3881. ; 161:1
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Tidskriftsartikel (refereegranskat)abstract
- We analyze the oxygen abundances of a stellar sample representative of the two major Galactic populations: the thin and thick disks. The aim is to investigate the differences between members of the Galactic disks and contribute to the understanding of the origin of oxygen chemical enrichment in the Galaxy. The analysis is based on the [O i] = 6300.30 A oxygen line in high-resolution spectra (R similar to 52,500) obtained from the Gaia-ESO public spectroscopic Survey (GES). By comparing the observed spectra with a theoretical data set computed in LTE with the SPECTRUM synthesis and ATLAS12 codes, we derive the oxygen abundances of 516 FGK dwarfs for which we have previously measured carbon abundances. Based on kinematic, chemical, and dynamical considerations, we identify 20 thin and 365 thick disk members. We study the potential trends of both subsamples in terms of their chemistry ([O/H], [O/Fe], [O/Mg], and [C/O] versus [Fe/H] and [Mg/H]), age, and position in the Galaxy. The main results are that (a) [O/H] and [O/Fe] ratios versus [Fe/H] show systematic differences between thin and thick disk stars with an enhanced O abundance of thick disk stars with respect to thin disk members and a monotonic decrement of [O/Fe] with increasing metallicity, even at metal-rich regime; (b) there is a smooth correlation of [O/Mg] with age in both populations, suggesting that this abundance ratio can be a good proxy of stellar ages within the Milky Way; and (c) thin disk members with [Fe/H] 0 display a [C/O] ratio smaller than the solar value, suggesting a possibly outward migration of the Sun from lower Galactocentric radii.
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| 8. |
- Tziraki, Chariklia, et al.
(författare)
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Rethinking palliative care in a public health context : addressing the needs of persons with non-communicable chronic diseases
- 2020
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Ingår i: Primary Health Care Research and Development. - : Cambridge University Press. - 1463-4236 .- 1477-1128. ; 21
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Tidskriftsartikel (refereegranskat)abstract
- Non-communicable chronic diseases (NCCDs) are the main cause of morbidity and mortality globally. Demographic aging has resulted in older populations with more complex healthcare needs. This necessitates a multilevel rethinking of healthcare policies, health education and community support systems with digitalization of technologies playing a central role. The European Innovation Partnership on Active and Healthy Aging (A3) working group focuses on well-being for older adults, with an emphasis on quality of life and healthy aging. A subgroup of A3, including multidisciplinary stakeholders in health care across Europe, focuses on the palliative care (PC) model as a paradigm to be modified to meet the needs of older persons with NCCDs. This development paper delineates the key parameters we identified as critical in creating a public health model of PC directed to the needs of persons with NCCDs. This paradigm shift should affect horizontal components of public health models. Furthermore, our model includes vertical components often neglected, such as nutrition, resilience, well-being and leisure activities. The main enablers identified are information and communication technologies, education and training programs, communities of compassion, twinning activities, promoting research and increasing awareness amongst policymakers. We also identified key 'bottlenecks': inequity of access, insufficient research, inadequate development of advance care planning and a lack of co-creation of relevant technologies and shared decision-making. Rethinking PC within a public health context must focus on developing policies, training and technologies to enhance person-centered quality life for those with NCCD, while ensuring that they and those important to them experience death with dignity.
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