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- Rona, P.A., et al.
(author)
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Carslberg ridge and mid-atlantic ridge : slow-spreading apparent analogs
- 2005
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In: AGU, Fall Meeting. - : American Geophysical Union (AGU).
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Conference paper (other academic/artistic)abstract
- We compare morphology, tectonics, petrology, and hydrothermal activity of a known section of the Mid-Atlantic Ridge (MAR) between the Kane and Atlantis fracture zones (full multi-beam coverage 21N to 31N) to the lesser known Carlsberg Ridge (CR; limited multi-beam coverage plus satellite altimetry). The CR extends from the Owen Fracture Zone (10N) to the Vityaz Fracture Zone (5S) and spreads at half-rates (~1.2-1.8 cm/yr) similar to the MAR: 1) Morphology: Both ridges exhibit distinct segmentation (primarily sinistral) and axial valleys with high floor to crest relief (range 1122-1771 m). Average lengths of segments (CR: 70 km; MAR: 50 km) and crest-to crest width of the axial valley are greater on the CR (40 km) than MAR (23 km). Axial volcanic ridges form the neovolcanic zone on both ridges, typically 2.6 km wide and 213 m high on the CR. Average water depth near segment centers is greater on the MAR (3933 m) than the CR (3564 m). V-shaped patterns oblique to the spreading axis are present on both ridges. 2) Tectonics: Segments on each ridge are predominantly separated by short-offset (<30 km) non-transform discontinuities with longer transform faults generally spaced hundreds of kilometers apart. Bulls-eye Mantle Bouguer Lows (-30 to -50 mgal) are present at centers of spreading segments on both ridges. Metamorphic core complexes of lower crust and upper mantle are present on the MAR section (at fracture zones) and at least at one locality at 58.33E on the CR. 3) Petrology: MORB composition from our 20 stations along the CR fall into the MORB family, with no evidence of hotspot inputs (no excess K or Nb), or extreme fractionation, similar to the MAR section. REE and trace element patterns between 57E and 61E on the CR indicate increasing melt depletion to the northwest, while glasses exhibit a striking systematic increase in MgO (decrease in fractionation) to the northwest and attain among the most primitive composition of any ocean ridge adjacent to the Owen fracture zone (9.93wt percent). Sr, Nd, and Pb isotopic compositions of Indian Ocean MORB are distinct from those of other oceans. They exhibit relatively higher 87Sr/86Sr, and lower 143Nd/144Nd, 207Pb/204Pb and 208Pb/204Pb for a given 206Pb/204Pb invoking mixing and regional-scale contamination of a depleted mantle with a variously designated enriched reservoir (EM1, EM2, DUPAL, etc.). 4) Hydrothermal activity: The MAR section encompasses a low-T hydrothermal field driven by the serpentinization at the Atlantis fracture zone (Lost City at 30N), and three high-temperature fields driven by magmatic heat in the axial valley (Broken Spur 29N, TAG 26N, and Snake Pit 23N). A 70 km-long, 1000 m-thick megaplume was detected in the water column up to 1400 m above the CR axial valley centered at 6.05N, 60.95E in August 2003, the first clear evidence of high-temperature hydrothermal activity on the CR. Further CR hydrothermal evidence includes relict sulfide chimneys at 58E; Mn-oxide coatings on basalts in the axial valley with Fe/Mn ratios at the boundary between hydrogenous and hydrothermal composition with thickness at two stations (1.67S, 67.77E; 5.35S, 68.62E) suggestive of hydrothermal input; and a d3He anomaly (166 per mil) in the water column at one of our stations in April 1979 (5.35S, 68.62E).
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- Rona, P.A., et al.
(author)
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Serpentinized ultramafics and hydrothermal activity at the mid-atlantic ridge crest near 15°N
- 1987
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In: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 92:B2, s. 1417-1427
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Journal article (peer-reviewed)abstract
- The initial occurrence of serpentinized ultramafic rocks at the nontransform intersection of a wall of a rift valley with the wall of a fracture zone is described from a site at the Fifteen Twenty Fracture Zone. The ultramafics crop out in block-faulted terrain on the upper portion of the eastern intersection between the rift valley and fracture zone walls in water depths between 2910 and 3300 m. They comprise cumulate harzburgites, pyroxenites, Iherzolites, and wehrlites, as well as gabbronorites, olivine gabbronorites, gabbropegmatites, and alteration products including serpentinites, bastite serpentinites, and asbestos. The Ti-Zr-Y relations and relatively constant Zr/Ti ratio in basalts recovered with the ultramafic rocks indicate a cogenetic relation from a common magmatic source that has undergone a late stage differentiation in the lower crust. Ongoing hydrothermal activity is indicated by chemical anomalies (δ3He, Mn) in the near-bottom water at the ultramafic outcrop. The upwelling hydrothermal circulation apparently follows crust-penetrating faults that may have controlled the diapiric ascent of the serpentinites and that continue to tap degassing magma and/or mantle. The observations presented indicate that ultramafic cumulates form beneath the rift valley adjacent to long-offset (>100 km) ridge-ridge transform faults, where they are serpentinized by hydrothermal processes within the initial 1 × 106 years of generation of lithosphère at a slow spreading axis. The corners formed by the intersections of the walls of a rift valley with both the transform (RT corner) and the nontransform (RN corner) portions of these fracture zones are principal loci of diapiric emplacement of serpentinized ultramafics.
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- Wheeler, Eleanor, et al.
(author)
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Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations : A transethnic genome-wide meta-analysis
- 2017
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In: PLoS Medicine. - : PUBLIC LIBRARY SCIENCE. - 1549-1277 .- 1549-1676. ; 14:9
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Journal article (peer-reviewed)abstract
- Background: Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identified 18 HbA1c-associated genetic variants. These variants proved to be classifiable by their likely biological action as erythrocytic (also associated with erythrocyte traits) or glycemic (associated with other glucose-related traits). In this study, we tested the hypotheses that, in a very large scale GWAS, we would identify more genetic variants associated with HbA1c and that HbA1c variants implicated in erythrocytic biology would affect the diagnostic accuracy of HbA1c. We therefore expanded the number of HbA1c-associated loci and tested the effect of genetic risk-scores comprised of erythrocytic or glycemic variants on incident diabetes prediction and on prevalent diabetes screening performance. Throughout this multiancestry study, we kept a focus on interancestry differences in HbA1c genetics performance that might influence race-ancestry differences in health outcomes.Methods & findings: Using genome-wide association meta-analyses in up to 159,940 individuals from 82 cohorts of European, African, East Asian, and South Asian ancestry, we identified 60 common genetic variants associated with HbA1c. We classified variants as implicated in glycemic, erythrocytic, or unclassified biology and tested whether additive genetic scores of erythrocytic variants (GS-E) or glycemic variants (GS-G) were associated with higher T2D incidence in multiethnic longitudinal cohorts (N = 33,241). Nineteen glycemic and 22 erythrocytic variants were associated with HbA1c at genome-wide significance. GS-G was associated with higher T2D risk (incidence OR = 1.05, 95% CI 1.04-1.06, per HbA1c-raising allele, p = 3 x 10-29); whereas GS-E was not (OR = 1.00, 95% CI 0.99-1.01, p = 0.60). In Europeans and Asians, erythrocytic variants in aggregate had only modest effects on the diagnostic accuracy of HbA1c. Yet, in African Americans, the X-linked G6PD G202A variant (T-allele frequency 11%) was associated with an absolute decrease in HbA1c of 0.81%-units (95% CI 0.66-0.96) per allele in hemizygous men, and 0.68%-units (95% CI 0.38-0.97) in homozygous women. The G6PD variant may cause approximately 2% (N = 0.65 million, 95% CI0.55-0.74) of African American adults with T2Dto remain undiagnosed when screened with HbA1c. Limitations include the smaller sample sizes for non-European ancestries and the inability to classify approximately one-third of the variants. Further studies in large multiethnic cohorts with HbA1c, glycemic, and erythrocytic traits are required to better determine the biological action of the unclassified variants.Conclusions: As G6PD deficiency can be clinically silent until illness strikes, we recommend investigation of the possible benefits of screening for the G6PD genotype along with using HbA1c to diagnose T2D in populations of African ancestry or groups where G6PD deficiency is common. Screening with direct glucose measurements, or genetically-informed HbA1c diagnostic thresholds in people with G6PD deficiency, may be required to avoid missed or delayed diagnoses.
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