| 1. |
- Liu, Yongsheng, et al.
(författare)
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Experimental Therapy of HER2-Expressing Xenografts Using the Second-Generation HER2-Targeting Affibody Molecule 188Re-ZHER2:41071
- 2022
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Ingår i: Pharmaceutics. - : MDPI. - 1999-4923. ; 14:5
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Tidskriftsartikel (refereegranskat)abstract
- HER2-targeted radionuclide therapy might be helpful for the treatment of breast, gastric, and ovarian cancers which have developed resistance to antibody and antibody-drug conjugate-based therapies despite preserved high HER2-expression. Affibody molecules are small targeting proteins based on a non-immunoglobulin scaffold. The goal of this study was to test in an animal model a hypothesis that the second-generation HER2-targeting Affibody molecule 188Re-ZHER2:41071 might be useful for treatment of HER2-expressing malignant tumors. ZHER2:41071 was efficiently labeled with a beta-emitting radionuclide rhenium-188 (188Re). 188Re-ZHER2:41071 demonstrated preserved specificity and high affinity (KD = 5 ± 3 pM) of binding to HER2-expressing cells. In vivo studies demonstrated rapid washout of 188Re from kidneys. The uptake in HER2-expressing SKOV-3 xenografts was HER2-specific and significantly exceeded the renal uptake 4 h after injection and later. The median survival of mice, which were treated by three injections of 16 MBq 188Re-ZHER2:41071 was 68 days, which was significantly longer (<0.0001 in the log-rank Mantel-Cox test) than survival of mice in the control groups treated with vehicle (29 days) or unlabeled ZHER2:41071 (27.5 days). In conclusion, the experimental radionuclide therapy using 188Re-ZHER2:41071 enabled enhancement of survival of mice with human tumors without toxicity to the kidneys, which is the critical organ.
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| 2. |
- Rex, Emma, et al.
(författare)
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A systems perspective on chemical production from mixed food waste : The case of bio-succinate in Sweden
- 2017
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Ingår i: Resources, Conservation and Recycling. - : Elsevier. - 0921-3449 .- 1879-0658. ; 125, s. 86-97
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Tidskriftsartikel (refereegranskat)abstract
- The option of producing the chemical succinic acid from bio-based resources is well in line with current political and industrial ambitions for a bio-based economy. A little explored but intriguing biomass feedstock opportunity is food waste. Mixed food waste is especially appealing as it represents less resource competition than more homogenous food waste fractions. The feasibility of producing succinic acid from mixed food waste depends on both technical and societal system structures. Therefore, to assess the production prospect, it is important to investigate all relevant system components. This study explores from such multiple perspectives the feasibility of chemical production as a viable added pathway for mixed food waste, using microbial production of succinic acid from municipal solid waste in Sweden as an example. The perspectives explored are: 1) feedstock feasibility, 2) societal drivers and barriers for technology progress, and 3) resource availability. Findings show that even though, from a technical feasibility and resource availability perspective, production seems possible, it lacks institutional support and actor commitment and alignment for development in Sweden. Findings also show that a holistic and interdisciplinary systems perspective contributes valuable insight when assessing prospects for bio-based chemicals.
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| 3. |
- Rex, Emma, et al.
(författare)
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A systems perspective on chemical production from mixed food waste: The case of bio-succinate in Sweden
- 2018
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- The option of producing the chemical succinic acid from bio-based resources is well in line with current political and industrial ambitions for a bio-based economy. A little explored but intriguing biomass feedstock opportunity is food waste. Mixed food waste is especially appealing as it represents less resource competition than more homogenous food waste fractions. The feasibility of producing succinic acid from mixed food waste depends on both technical and societal system structures. Therefore, to assess the production prospect, it is important to investigate all relevant system components. This study explores from such multiple perspectives the feasibility of chemical production as a viable added pathway for mixed food waste, using microbial production of succinic acid from municipal solid waste in Sweden as an example. The perspectives explored are: 1) feedstock feasibility, 2) societal drivers and barriers for technology progress, and 3) resource availability. Findings show that even though, from a technical feasibility and resource availability perspective, production seems possible, it lacks institutional support and actor commitment and alignment for development in Sweden. Findings also show that a holistic and interdisciplinary systems perspective contributes valuable insight when assessing prospects for bio-based chemicals.
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