| 1. |
- Angelin, Martin, et al.
(författare)
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Qdenga® - A promising dengue fever vaccine; can it be recommended to non-immune travelers?
- 2023
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Ingår i: Travel Medicine and Infectious Disease. - : Elsevier. - 1477-8939 .- 1873-0442. ; 54
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Tidskriftsartikel (refereegranskat)abstract
- Qdenga® has been approved by the European Medicines Agency (EMA) for individuals > 4 years of age and for use according to national recommendations. The vaccine shows high efficacy against virologically confirmed dengue and severe dengue in clinical studies on 4–16-year old's living in endemic areas. For individuals 16–60 years old only serological data exists and there is no data for individuals > 60 years. Its use as a travel vaccine is still unclear. We present the studies behind the approval and the recommendations for travelers as issued by the Swedish Society for Infectious Diseases Physicians.
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| 2. |
- Briggner, Lars-Erik, et al.
(författare)
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In Silico Solid State Perturbation for Solubility Improvement
- 2014
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Ingår i: ChemMedChem. - : Wiley. - 1860-7179 .- 1860-7187. ; 9:4, s. 724-726
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Tidskriftsartikel (refereegranskat)abstract
- Solubility is a frequently recurring issue within pharmaceutical industry, and new methods to proactively resolve this are of fundamental importance. Here, a novel methodology is reported for intrinsic solubility improvement, using insilico prediction of crystal structures, by perturbing key interactions in the crystalline solid state. The methodology was evaluated with a set of benzodiazepine molecules, using the two-dimensional molecular structure as the only a priori input. The overall trend in intrinsic solubility was correctly predicted for the entire set of benzodiazepines molecules. The results also indicate that, in drug compound series where the melting point is relatively high (i.e., brick dust compounds), the reported methodology should be very suitable for identifying strategically important molecular substitutions to improve solubility. As such, this approach could be a useful predictive tool for rational compound design in the early stages of drug development.
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| 3. |
- Briggner, Lars-Erik, et al.
(författare)
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Solid-State Perturbation for Solubility Improvement : A Proof of Concept
- 2011
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Ingår i: ChemMedChem. - : Wiley. - 1860-7179. ; 6:1, s. 60-62
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Tidskriftsartikel (refereegranskat)abstract
- Simple and rational: The intrinsic solubility of a compound can be systematically improved by perturbing key interactions in its crystal structure. By carefully choosing the perturbation, the end result will be a molecule similar to the original one, but with significantly higher solubility. This methodology is demonstrated on a subset of benzodiazepines, resulting in significant improvement of their solubility.
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| 4. |
- Bring, Torun, et al.
(författare)
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Colour development in copper ruby alkali silicate glasses. : Part 2. The effect of tin (II) oxide and antimony (III) oxide
- 2007
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Ingår i: GLASS TECHNOLOGY-EUROPEAN JOURNAL OF GLASS SCIENCE AND TECHNOLOGY PART A. - : Society of Glass Technology. - 1753-3546. ; 48:3, s. 142-148
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Tidskriftsartikel (refereegranskat)abstract
- The effect of Sb3+ and Sn2+ during the heat treatment of copper ruby alkali silicate glasses is investigated. The reducing power of SnO and Sb2O3 with respect to Cu is investigated and it is concluded that SnO has the strongest reducing capability. When Cu2O and SnO concentrations are low, minor additions of Sb2O3 have an observable impact on colour development and absorbance, as thin pieces of glass develop a bluish tint and a larger shift towards longer wavelengths is observed in UV/vis spectra. The differences in colour and spectra are suggested to be caused by differences in size of the colour forming agent, Cu metal particles.
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| 5. |
- Bring, Torun, et al.
(författare)
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Colour development in copper ruby alkali silicate glasses : Part 1. The impact of tin (II) oxide, time and temperature
- 2007
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Ingår i: Glass Technology, Eur J Glass Sci Technol A. - : Society of Glass Technology. ; 48:2, s. 101-108
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Tidskriftsartikel (refereegranskat)abstract
- The development of the red colour in copper ruby alkali silicate glasses has been studied by means of ultraviolet/visible spectroscopy, TEM and EXAFS. The results show that in both red and slightly overstruck, brownish glasses the colour is due to clusters of metallic copper. Before striking non-coloured glasses contain mainly cuprous ions, Cu+. Tin acts as a reducing agent but also has an accelerating effect on colour development.
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| 6. |
- Fuchi, Tokio, et al.
(författare)
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Microdialysis of rat skeletal muscle and adipose tissue : dynamics of the interstitial glucose pool.
- 1994
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Ingår i: Acta Physiologica Scandinavica. - 0001-6772 .- 1365-201X. ; 151:2, s. 249-60
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Tidskriftsartikel (refereegranskat)abstract
- Microdialysis was evaluated as a method for studying glucose metabolism in skeletal muscle. Dialysis probes (0.5 x 10 mm) were perfused at 0.5 or 1.0 microliter min-1. Based upon perfusion with glucose, the muscle interstitial glucose concentration was estimated to be 6.9 +/- 0.3 mM (n = 14), which was not significantly different from the blood glucose level. With insulin infusion (1200 mU kg-1 body wt i.v.), the insulin-induced change in the glucose concentration of the interstitial space of muscle was of equal magnitude to that of blood and adipose tissue. In spite of this, when the perfusion medium was not supplemented with glucose, the glucose concentration decreased more in skeletal muscle dialysates (to 36.7 +/- 4.9% of the initial level) than in blood (to 29.7 +/- 5.0%) but less than in adipose tissue (to 17.7 +/- 4.9% of the initial level) (P < 0.05). The results indicate that these differences are due to tissue-specific differences in the dynamic balance between the supply to, and removal from, the interstitial glucose pool. This balance is revealed as a result of the constant glucose drainage by the microdialysis probe. The present results show that, in skeletal muscle, increases in glucose uptake occur with a concomitant increase in tissue blood flow as revealed by the microdialysis ethanol technique, whereas in adipose tissue the glucose uptake increases in the absence of a corresponding increase in blood flow.
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| 7. |
- Hamrin, Kerstin, et al.
(författare)
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Microdialysis in human skeletal muscle : effects of adding a colloid to the perfusate.
- 2002
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Ingår i: Journal of applied physiology. - : American Physiological Society. - 8750-7587 .- 1522-1601. ; 92:1, s. 385-93
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Tidskriftsartikel (refereegranskat)abstract
- Microdialysis catheters (CMA-60 with a polyamide dialysis membrane; 20,000-molecular wt cutoff) were either immersed in an external medium or were inserted in the quadriceps femoris muscle of healthy subjects, using perfusate with or without dextran 70. Varying the position of the outflow tubing induced changes in hydrostatic pressure. The sample volumes were significantly smaller in catheters perfused without a colloid compared with those perfused with a colloid [11-50% (in vitro) and 8-59% (in vivo) lower than in colloid-perfused catheters with the same position of the outflow tubing]. The sample volumes were also significantly smaller when the dialysis membrane was influenced by maximal hydrostatic pressure (above position) compared with minimal hydrostatic pressure (below position) [7-38% (in vitro) and 3-46% (in vivo) lower than in catheters in the below position with the same perfusion fluid]. In vivo, glucose concentration at a perfusion flow rate of 0.33 microl/min was higher when the catheters were perfused without a colloid [18-28% higher than in colloid-perfused catheters with the same position of the outflow tubing (P < 0.001)] than with a colloid. A corresponding difference also tended to occur with lactate, glycerol, and urea. At 0.16 microl/min, the glucose concentration was the same irrespective of whether fluid loss had been counteracted by colloid inclusion or by lowering of outlet tubing. The mechanism behind the observed concentration difference is thought to be a higher effective perfusion flow rate when fluid loss is prevented at low-perfusion flows. This study shows that fluid imbalances can have important implications for microdialysis results at low-perfusion flow rates.
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| 8. |
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| 9. |
- Henriksson, Jan, et al.
(författare)
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Per-Olof Åstrand : Nekrolog
- 2015
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Annan publikation (populärvet., debatt m.m.)abstract
- Nekrolog över Per-Olof ÅstrandProfessor emeritus Per-Olof Åstrand har avlidit i en ålder av 92 år. Hans närmaste anhöriga är makan Irma och barnen Elin och Per med familjer.Per-Olof Åstrand föddes i Bredaryd i Småland den 21 oktober 1922, och avled den 2 januari 2015 i Näsby Park norr om Stockholm. Efter värnplikt och beredskapstjänstgöring i pansartrupperna under andra världskriget kom han 1944 till Kungl. Gymnastiska Centralinstitutet (GCI/GIH) för studier till gymnastiklärare. Vid sluttentamen i fysiologi var hans svar så avancerade att den ansvarige läraren bad professorn, Erik Hohwü Christensen, att rätta dem. Kort därefter fick GCI:s fysiologiska institution en ny amanuens.Efter gymnastikdirektörsexamen 1946 följde läkarstudier, och parallellt med dessa inleddes avhandlingsarbetet ”Experimental studies of physical working capacity in relation to sex and age”, som försvarades 1952. Genom detta utvecklades en metodik för att mäta maximal syreupptagning. Det blev en avgörande variabel att relatera till i hans senare forskning om den cirkulatoriska och respiratoriska anpassningen till fysiskt arbete och träning. Det submaximala konditionstest som P.-O., och hans blivande hustru Irma Ryhming, publicerade år 1954 bidrog till att göra GCI känt över världen. Det finns fog att benämna honom som ”den vetenskapligt baserade konditionsträningens fader”. 1970 blev han professor i kroppsövningarnas fysiologi vid GIH.P.-O. visade tidigt ett stort intresse för undervisning, och många mötte honom i populärvetenskapliga skrifter såsom ”Kondition och hälsa” och ”Bättre kondition”, men det var genom den omfattande läroboken ”Textbook of Work Physiology: Physiological Bases for Exercise”, skriven tillsammans med Kaare Rodahl, som han blev det riktigt stora namnet inom internationell arbetsfysiologi. Där framträdde holisten Åstrand med en bredd och ett djup som ingen förr hade fångat och skrivit fram. Denna bok, P.-O:s pedagogiska förmåga och engagemang har haft avgörande betydelse för många studenter och kolleger.Hans gärningar gjorde honom till ledamot i många lärda sällskap och hedersdoktor vid ett antal universitet ute i världen. Därtill var han en hedersman, med en personlighet präglad av en stor omtanke, slagkraftig humor och generös spiritualitet, ofta med inslag av en särpräglad musikalisk förmåga. För oss som studenter och lärare vid GIH kom samvaron med P.-O. ofta att formas till högtidsstunder. En legendar har nu lämnat oss i djupaste sorg, men också i tacksamhet över allt han bidrog med i våra liv.Jan HenrikssonHans RosdahlPeter SchantzHarriet Wallberg
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