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- Ingildsen, P, et al.
(författare)
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Modelling and control strategy testing of biological and chemical phosphorus removal at Avedore WWTP
- 2006
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Ingår i: Water Science and Technology. - : IWA Publishing. - 0273-1223 .- 1996-9732. ; 53:4-5, s. 105-113
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Tidskriftsartikel (refereegranskat)abstract
- The biological phosphorus removal process is often implemented at plants by the construction of an anaerobic bio-p tank in front of the traditional N removing plant configuration. However, biological phosphorus removal is also observed in plant configurations constructed only for nitrogen removal and simultaneous or post-precipitation. The operational experience with this "accidental" biological phosphorus removal is often mixed with quite a lot of frustration, as the process seems to come and go and hence behaves quite uncontrollably. The aim of this work is to develop ways of intentionally exploiting the biological phosphorus process by the use of instrumentation, control and automation to reduce the consumption of precipitants. Means to this end are first to calibrate a modified ASM2d model to a full-scale wastewater treatment plant (WWTP), including both biological and chemical phosphorus removal and a model of the sedimentation process. Second, based on the calibrated model a benchmark model is developed and various control strategies for biological phosphorus removal are tested. Experiences and knowledge gained from the strategies presented and discussed in this paper are vital inputs for the full-scale implementation of a control strategy for biological phosphorus removal at Avedore WWTP, which is described in another paper. The two papers hence show a way to bridge the gap from model to full implementation.
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- Rosén, Christian, et al.
(författare)
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Introducing biological phosphorus removal in an alternating plant by means of control: a full scale study
- 2006
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Ingår i: Water Science and Technology. - : IWA Publishing. - 0273-1223 .- 1996-9732. ; 53:4-5, s. 133-141
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Tidskriftsartikel (refereegranskat)abstract
- In this paper, a control strategy for introducing enhanced biological phosphorus removal (EBPR) in an alternating plant designed for enhanced biological nitrogen removal (EBNR) is presented. Alternating aerobic and anaerobic conditions to promote EBPR are provided by controlling the phases of the operational cycle, instead of a separate anaerobic volume. By utilising the control schemes already built in the STAR((R)) control system for nitrogen removal, the control strategy is fully integrated in the system. The control system relies on on-line measurements of nitrogen (ammonia and/or nitrate) and orthophosphate. The control strategy has been implemented in full-scale operation at the Avedore wastewater treatment plant in Denmark and the results show clear indications of success. The control strategy has operated robustly for several months with a 60% decrease in use of precipitation chemicals.
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- Westerberg, LS, et al.
(författare)
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Activating WASP mutations associated with X-linked neutropenia result in enhanced actin polymerization, altered cytoskeletal responses, and genomic instability in lymphocytes
- 2010
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Ingår i: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 207:6, s. 1145-1152
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Tidskriftsartikel (refereegranskat)abstract
- X-linked neutropenia (XLN) is caused by activating mutations in the Wiskott-Aldrich syndrome protein (WASP) that result in aberrant autoinhibition. Although patients with XLN appear to have only defects in myeloid lineages, we hypothesized that activating mutations of WASP are likely to affect the immune system more broadly. We generated mouse models to assess the role of activating WASP mutations associated with XLN (XLN-WASP) in lymphocytes. XLN-WASP is expressed stably in B and T cells and induces a marked increase in polymerized actin. XLN-WASP–expressing B and T cells migrate toward chemokines but fail to adhere normally. In marked contrast to WASP-deficient cells, XLN-WASP–expressing T cells proliferate normally in response to cell-surface receptor activation. However, XLN-WASP–expressing B cells fail to proliferate and secrete lower amounts of antibodies. Moreover, XLN-WASP expression in lymphocytes results in modestly increased apoptosis associated with increased genomic instability. These data indicate that there are unique requirements for the presence and activation status of WASP in B and T cells and that WASP-activating mutations interfere with lymphocyte cell survival and genomic stability.
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