| 1. |
- Unsbo, Hanna, et al.
(författare)
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Indicators for microplastic flows
- 2022
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- To reduce the leakage of plastic into nature the Swedish Environmental Protection Agency (Swedish EPA) has established two indicators for follow-up: “Littering of objects containing plastic” and “Estimated total leakage of microplastics in Sweden”. The aim of this project was to propose detailed indicators for prioritised sources and pathways that may be used to annually follow-up the spread of microplastics in Sweden. This has been done through expert workshops, interviews, literature studies, and in close dialog with Swedish EPA. The following aspects were considered for the proposed indicators: data availability, representativeness, possible sampling- and analytical methods, as well as calculation approaches, method uncertainties and its cost-efficiency. Based on these results, the following indicators are suggested to be used to follow-up leakage of microplastics from the sources and pathways prioritised by Swedish EPA:Tyre wear - Microplastics from tyre wear (kg/y) based on national annual traffic activity data (vehicle km) for different vehicle classes. The annual traffic activity data is multiplied with vehicle class-specific emission factors (g/km) to calculate the total leakage.Artificial grass pitches (AGP) - 1) Replenishment of infill on Swedish AGP:s based on an annual survey where facility owners report actual replenished infill (kg/m2). To scale up the amount (kg/y) of replenished infill to national level, an estimate of the total area of AGP:s with rubber infill could be estimated based on available statistics. 2) A certification system for AGP:s in Sweden is introduced to provide well-managed pitches. The certification should assure that the facility owners have made certain measures to reduce emissions of microplastics. The indicator to follow-up is the number of certified artificial grass pitches.Industrial production of plastic pellets - Introduced reporting requirement of microplastics emissions for all Swedish producers of plastic pellets based on sampling and analyses being performed in effluent water. Data on microplastics leakage (kg/y) can be made available through changes of relevant permits or via new legislation.Architectural and antifouling paint - Weight of polymers in architectural paint, antifouling paint and other hull paint put on the Swedish market annually (kg/y) are considered to reflect the amount of microplastics spread to nature from paint.Littering – Total annual amount (kg/y) of plastic litter based on the annual national plastic litter monitoring program to be introduced 2023 and/or the existing urban litter monitoring program run by The Keep Sweden Tidy Foundation (HSR). Macrolitter is considered to reflect the leakage of microplastics to nature.Wastewater – 1) Measured average load of microplastics (g/pe, y) in wastewater treatment plants, both incoming and effluent water. This can be conducted through an extension of the existing Swedish EPA's Environmental Toxics Coordination's sub-programme on environmental toxins in the urban environment, analysing occurrences of chemicals in effluent water from sewage treatment plants, to also include microplastics. By analysing the water for total amount of microplastics as well as fractions such as rubber particles and textile fibres, the results can also be used as an indicator for the source "laundry" and the pathway "stormwater". 2) Reported average volume (m3/pe, y) of sanitary sewer overflow at WWTP and from the sewer systems in Sweden based on existing environmental reporting. 3) Measured average load of microplastics (g/pe, y) in WWTP sludge based on the same monitoring program as indicator 1).Wind – Measured average yearly deposition (g/m2, y) of microplastics in bulk deposition analysed based on volume proportional monthly samples in the existing the Swedish Throughfall Monitoring Network.Since the suggested indicators are mainly based on existing data and monitoring programmes it should be possible to run development projects for suggested indicators in 2023, aiming for full implementation by 2024. When several indicators are proposed, they are prioritized in number order.It has not been possible for the project to quantify a cost for suggested indicator system. However, mostly existing and yearly available data is utilised in the proposed indicators. Due to this, it is considered that the suggestions can be implemented without high costs for facility owners and authorities.
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| 2. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.522.7) and 16.5 cm (13.319.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 3. |
- Bentham, James, et al.
(författare)
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A century of trends in adult human height
- 2016
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Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 5
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Tidskriftsartikel (refereegranskat)abstract
- Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3– 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8– 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
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| 4. |
- Bergström, Göran, 1964, et al.
(författare)
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Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population
- 2021
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Ingår i: Circulation. - Philadelphia : American Heart Association. - 0009-7322 .- 1524-4539. ; 144:12, s. 916-929
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Tidskriftsartikel (refereegranskat)abstract
- Background: Early detection of coronary atherosclerosis using coronary computed tomography angiography (CCTA), in addition to coronary artery calcification (CAC) scoring, may help inform prevention strategies. We used CCTA to determine the prevalence, severity, and characteristics of coronary atherosclerosis and its association with CAC scores in a general population.Methods: We recruited 30 154 randomly invited individuals age 50 to 64 years to SCAPIS (the Swedish Cardiopulmonary Bioimage Study). The study includes individuals without known coronary heart disease (ie, no previous myocardial infarctions or cardiac procedures) and with high-quality results from CCTA and CAC imaging performed using dedicated dual-source CT scanners. Noncontrast images were scored for CAC. CCTA images were visually read and scored for coronary atherosclerosis per segment (defined as no atherosclerosis, 1% to 49% stenosis, or ≥50% stenosis). External validity of prevalence estimates was evaluated using inverse probability for participation weighting and Swedish register data.Results: In total, 25 182 individuals without known coronary heart disease were included (50.6% women). Any CCTA-detected atherosclerosis was found in 42.1%; any significant stenosis (≥50%) in 5.2%; left main, proximal left anterior descending artery, or 3-vessel disease in 1.9%; and any noncalcified plaques in 8.3% of this population. Onset of atherosclerosis was delayed on average by 10 years in women. Atherosclerosis was more prevalent in older individuals and predominantly found in the proximal left anterior descending artery. Prevalence of CCTA-detected atherosclerosis increased with increasing CAC scores. Among those with a CAC score >400, all had atherosclerosis and 45.7% had significant stenosis. In those with 0 CAC, 5.5% had atherosclerosis and 0.4% had significant stenosis. In participants with 0 CAC and intermediate 10-year risk of atherosclerotic cardiovascular disease according to the pooled cohort equation, 9.2% had CCTA-verified atherosclerosis. Prevalence estimates had excellent external validity and changed marginally when adjusted to the age-matched Swedish background population.Conclusions: Using CCTA in a large, random sample of the general population without established disease, we showed that silent coronary atherosclerosis is common in this population. High CAC scores convey a significant probability of substantial stenosis, and 0 CAC does not exclude atherosclerosis, particularly in those at higher baseline risk.
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| 5. |
- Bergström, Göran, et al.
(författare)
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Prevalence of Subclinical Coronary Artery Atherosclerosis in the General Population
- 2021
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Ingår i: Circulation. - : Wolters Kluwer. - 0009-7322 .- 1524-4539. ; 144:12, s. 916-929
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Tidskriftsartikel (refereegranskat)abstract
- Background: Early detection of coronary atherosclerosis using coronary computed tomography angiography (CCTA), in addition to coronary artery calcification (CAC) scoring, may help inform prevention strategies. We used CCTA to determine the prevalence, severity, and characteristics of coronary atherosclerosis and its association with CAC scores in a general population.Methods: We recruited 30 154 randomly invited individuals age 50 to 64 years to SCAPIS (the Swedish Cardiopulmonary Bioimage Study). The study includes individuals without known coronary heart disease (ie, no previous myocardial infarctions or cardiac procedures) and with high-quality results from CCTA and CAC imaging performed using dedicated dual-source CT scanners. Noncontrast images were scored for CAC. CCTA images were visually read and scored for coronary atherosclerosis per segment (defined as no atherosclerosis, 1% to 49% stenosis, or ≥50% stenosis). External validity of prevalence estimates was evaluated using inverse probability for participation weighting and Swedish register data.Results: In total, 25 182 individuals without known coronary heart disease were included (50.6% women). Any CCTA-detected atherosclerosis was found in 42.1%; any significant stenosis (≥50%) in 5.2%; left main, proximal left anterior descending artery, or 3-vessel disease in 1.9%; and any noncalcified plaques in 8.3% of this population. Onset of atherosclerosis was delayed on average by 10 years in women. Atherosclerosis was more prevalent in older individuals and predominantly found in the proximal left anterior descending artery. Prevalence of CCTA-detected atherosclerosis increased with increasing CAC scores. Among those with a CAC score >400, all had atherosclerosis and 45.7% had significant stenosis. In those with 0 CAC, 5.5% had atherosclerosis and 0.4% had significant stenosis. In participants with 0 CAC and intermediate 10-year risk of atherosclerotic cardiovascular disease according to the pooled cohort equation, 9.2% had CCTA-verified atherosclerosis. Prevalence estimates had excellent external validity and changed marginally when adjusted to the age-matched Swedish background population.Conclusions: Using CCTA in a large, random sample of the general population without established disease, we showed that silent coronary atherosclerosis is common in this population. High CAC scores convey a significant probability of substantial stenosis, and 0 CAC does not exclude atherosclerosis, particularly in those at higher baseline risk.
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| 6. |
- Brännström, Sara, et al.
(författare)
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Microplastic Emissions from Paint
- 2023
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Swedish Environmental Emissions Data (SMED) is a collaboration between IVL Swedish Environmental Research Institute, SCB Statistics Sweden, the Swedish University of Agricultural Sciences (SLU), and the Swedish Meteorological and Hydrological Institute (SMHI).Recent attention has been focused on the potential environmental and health impacts of microplastics, but there is still significant knowledge missing regarding these impacts. The Swedish Environmental Protection Agency has is responsible for the national plastics coordination, in which one aim is to develop new knowledge in relation to important sources of microplastic emissions. Within the scope of this work, SMED has been assigned to review the role of paints as a source of microplastics and suggest feasible indicators to monitor annual release from paints.This report aims to compile existing knowledge of various paint and coating systems and their contribution to microplastic emissions. Sectors responsible for the highest emissions have been identified to facilitate prioritization of actions to lower microplastic emissions from paints. Additionally, this report proposes a key indicator for tracking annual national levels of microplastic emissions from paints.The report concludes that the sectors with the greatest risk for microplastic emissions from paint include architecture, antifouling and hull coatings, coatings used in general industry, and the automotive industry. In Sweden, data on the volume of architectural paints and antifouling/marine coatings placed on the market can be readily obtained from the Swedish product registry. However, information regarding paint usage in general industry and the automotive sector is limited because coatings are often applied overseas prior to import into Sweden and many of the products coated in Sweden are exported abroad.This project has developed a simplified method to calculate annual microplastic emissions from paint in Sweden including emissions from architectural and marine sectors. Emission factors for different parts of a paint’s lifecycle were included and a range of solid contents based on a set of commercially available paints were used to provide a worst case, best case, and average case. By using this method, release of microplastics from architectural paint was estimated at 209 to 3 700 tons per year and release from antifouling and hull coatings at 30 to 308 tons per year in Sweden.Comparing these numbers to estimated quantities of microplastic emissions from other sources, coatings are a substantial source of microplastics.Wear from road traffic is regarded as the largest source of microplastics in Sweden, accounting for about 7 674 tonnes per year. It has been estimated that the amount of synthetic fibres released from textiles is between 8 to 956 tons annually and that microplastic emissions from industrial plastic pellet production is between 12 to 235 tons annually (Magnusson et al., 2016).Since coatings typically need to meet various technical requirements to protect the underlying substrate from corrosion and wear, efforts to reduce microplastic releases from paint and coatings might incur higher costs and obstacles than efforts to address other microplastic sources such as littering.For future monitoring of microplastic emission from paint in Sweden, the project recommends the amounts of architectural and boat paints including antifouling coatings placed on the Swedish market annually (expressed in kg of dry weight) as indicators.
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| 7. |
- Candefjord, Stefan, 1981, et al.
(författare)
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Video support for prehospital stroke consultation: implications for system design and clinical implementation from prehospital simulations
- 2024
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Ingår i: BMC Medical Informatics and Decision Making. - 1472-6947. ; 24:1
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundVideo consultations between hospital-based neurologists and Emergency Medical Services (EMS) have potential to increase precision of decisions regarding stroke patient assessment, management and transport. In this study we explored the use of real-time video streaming for neurologist–EMS consultation from the ambulance, using highly realistic full-scale prehospital simulations including role-play between on-scene EMS teams, simulated patients (actors), and neurologists specialized in stroke and reperfusion located at the remote regional stroke center.MethodsVideo streams from three angles were used for collaborative assessment of stroke using the National Institutes of Health Stroke Scale (NIHSS) to assess symptoms affecting patient’s legs, arms, language, and facial expressions. The aim of the assessment was to determine appropriate management and transport destination based on the combination of geographical location and severity of stroke symptoms. Two realistic patient scenarios were created, with severe and moderate stroke symptoms, respectively. Each scenario was simulated using a neurologist acting as stroke patient and an ambulance team performing patient assessment. Four ambulance teams with two nurses each all performed both scenarios, for a total of eight cases. All scenarios were video recorded using handheld and fixed cameras. The audio from the video consultations was transcribed. Each team participated in a semi-structured interview, and neurologists and actors were also interviewed. Interviews were audio recorded and transcribed.ResultsAnalysis of video-recordings and post-interviews (n = 7) show a more thorough prehospital patient assessment, but longer total on-scene time, compared to a baseline scenario not using video consultation. Both ambulance nurses and neurologists deem that video consultation has potential to provide improved precision of assessment of stroke patients. Interviews verify the system design effectiveness and suggest minor modifications.ConclusionsThe results indicate potential patient benefit based on a more effective assessment of the patient’s condition, which could lead to increased precision in decisions and more patients receiving optimal care. The findings outline requirements for pilot implementation and future clinical tests.
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| 8. |
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| 9. |
- Eriksson, Hanna, et al.
(författare)
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Acute symptomatic seizures and epilepsy after mechanical thrombectomy
- 2020
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Ingår i: Epilepsy and Behavior. - : Elsevier BV. - 1525-5050 .- 1525-5069. ; 104
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Tidskriftsartikel (refereegranskat)abstract
- Purpose: The purpose of this study was to assess the incidence of acute symptomatic seizures and poststroke epilepsy (PSE) in a well-characterized cohort of patients treated with mechanical thrombectomy. In addition, we aimed to describe the dynamics of blood markers of brain injury in patients that developed PSE. Methods: Participants of the prospective AnStroke Trial of anesthesia method during mechanical thrombectomy were included and acute symptomatic seizures and PSE ascertained by medical records review. Blood markers neurofilament light (NFL), tau, glial fibrillary acidic protein (GFAP), S100 calcium-binding protein B (S100B), and neuron-specific enolase (NSE) were assessed. Results: A total of 90 patients with acute anterior ischemic stroke were included. Median National Institutes of Health Stroke Scale (NIHSS) at admission to hospital was 18 (IQR 15–22). Recanalization was achieved in 90%. No patients had epilepsy prior to the ischemic stroke. Four patients (4.4%) had acute symptomatic seizures and four patients (4.4%) developed PSE during the follow-up time (to death or last medical records review) of 0–4.5 years (median follow-up 1070 days IQR 777–1306), resulting in a two-year estimated PSE risk of 5.3% (95%CI: 0.2–10.4%). Blood markers of brain injury (NFL, tau, GFAP, S100B, and NSE) were generally above the cohort median in patients that developed PSE. Conclusions: The incidence of PSE after mechanical thrombectomy was low in our cohort. All blood biomarkers displayed interesting sensitivity and specificity. However, the number of PSE cases was small and more studies are needed on risk factors for PSE after mechanical thrombectomy. The potential of blood markers of brain injury markers to contribute to assessment of PSE risk should be explored further. This article is part of the Special Issue "Seizures & Stroke".
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| 10. |
- Fegraeus, Kim, et al.
(författare)
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An endothelial regulatory module links blood pressure regulation with elite athletic performance
- 2024
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Ingår i: PLOS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 20:6
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Tidskriftsartikel (refereegranskat)abstract
- The control of transcription is crucial for homeostasis in mammals. A previous selective sweep analysis of horse racing performance revealed a 19.6 kb candidate regulatory region 50 kb downstream of the Endothelin3 (EDN3) gene. Here, the region was narrowed to a 5.5 kb span of 14 SNVs, with elite and sub-elite haplotypes analyzed for association to racing performance, blood pressure and plasma levels of EDN3 in Coldblooded trotters and Standardbreds. Comparative analysis of human HiCap data identified the span as an enhancer cluster active in endothelial cells, interacting with genes relevant to blood pressure regulation. Coldblooded trotters with the sub-elite haplotype had significantly higher blood pressure compared to horses with the elite performing haplotype during exercise. Alleles within the elite haplotype were part of the standing variation in pre-domestication horses, and have risen in frequency during the era of breed development and selection. These results advance our understanding of the molecular genetics of athletic performance and vascular traits in both horses and humans.
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