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| 2. |
- Berntsson, Annika, 1979-
(författare)
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The sensitivity of Swedish alpine lakes to hydro-climatic changes during the Late Holocene
- 2014
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The thesis objective is to use lake sediments to investigate the relationships between chironomids, as proxy for temperature, and δ18O and minerogenic in-wash, as precipitation proxies, in northern Sweden during the Late Holocene. Three lakes along a N–S transect in the Scandes were studied using biological, geochemical and physical sediment properties, together with numerical methods. Emphasis was put on changes in hydrological and erosional regimes and the configurations of lake catchments in an attempt to avoid misinterpretation of the climate signals. Mean July air temperatures were inferred from the chironomid composition in sediment records covering the last 5000 yrs in Vindelfjällen Mountains in Mid Lapland and the last 1000 yrs in Jämtland. The temperature reconstructions underwent significance tests, suggesting reliable results for the Vindelfjällen reconstruction but not the Jämtland reconstruction. Data from XRF core scanning and grain size variations, interpreted together with catchment geomorphology, suggested periods with increased fluvial erosion. A major flood event occurred at the Vindelfjällen site c. 2800 cal. yr BP. Furthermore, this record indicates stream flow and wetland surface erosion during the last 1200 yrs. Seasonal variations in the amount of precipitation, reflecting changes in atmospheric circulation during the last 1000 yrs, were reconstructed based on δ18O in diatoms from one lake in Jämtland and one in northern Lapland. Relatively higher summer precipitation was inferred between AD 1000 and 1080, AD 1300 and 1440, and during the early 19th century as a result of a positive Arctic Oscillation mode. Changes in chironomid composition in the Jämtland lake were concurrent with shifts in δ18Odiatom suggesting indirect responses to circulation changes. Changes in precipitation are suggested to be an important factor that may cause the spatially variable results among chironomid-based July air temperature reconstructions in Scandinavia.
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| 3. |
- Dragsted, L., et al.
(författare)
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Metabolomic response to Nordic foods
- 2015
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Ingår i: Annals of Nutrition and Metabolism. - 0250-6807 .- 1421-9697. ; 67, s. 55-55
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Eichelmann, Fabian, et al.
(författare)
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Lipidome changes due to improved dietary fat quality inform cardiometabolic risk reduction and precision nutrition
- 2024
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Ingår i: Nature Medicine. - 1078-8956 .- 1546-170X. ; In Press
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Tidskriftsartikel (refereegranskat)abstract
- Current cardiometabolic disease prevention guidelines recommend increasing dietary unsaturated fat intake while reducing saturated fats. Here we use lipidomics data from a randomized controlled dietary intervention trial to construct a multilipid score (MLS), summarizing the effects of replacing saturated fat with unsaturated fat on 45 lipid metabolite concentrations. In the EPIC-Potsdam cohort, a difference in the MLS, reflecting better dietary fat quality, was associated with a significant reduction in the incidence of cardiovascular disease (−32%; 95% confidence interval (95% CI): −21% to −42%) and type 2 diabetes (−26%; 95% CI: −15% to −35%). We built a closely correlated simplified score, reduced MLS (rMLS), and observed that beneficial rMLS changes, suggesting improved dietary fat quality over 10 years, were associated with lower diabetes risk (odds ratio per standard deviation of 0.76; 95% CI: 0.59 to 0.98) in the Nurses’ Health Study. Furthermore, in the PREDIMED trial, an olive oil-rich Mediterranean diet intervention primarily reduced diabetes incidence among participants with unfavorable preintervention rMLS levels, suggestive of disturbed lipid metabolism before intervention. Our findings indicate that the effects of dietary fat quality on the lipidome can contribute to a more precise understanding and possible prediction of the health outcomes of specific dietary fat modifications.
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| 5. |
- Fridén, Michael, et al.
(författare)
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Hepatic Unsaturated Fatty Acids Are Linked to Lower Degree of Fibrosis in Non-alcoholic Fatty Liver Disease
- 2022
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Ingår i: Frontiers in Medicine. - : Frontiers Media SA. - 2296-858X. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- Background: The hepatic lipidome of patients with early stages of non-alcoholic fatty liver disease (NAFLD) has been fairly well-explored. However, studies on more progressive forms of NAFLD, i.e., liver fibrosis, are limited. Materials and methods: Liver fatty acids were determined in cholesteryl esters (CE), phospholipids (PL), and triacylglycerols (TAG) by gas chromatography. Cross-sectional associations between fatty acids and biopsy-proven NAFLD fibrosis (n = 60) were assessed using multivariable logistic regression models. Stages of fibrosis were dichotomized into none-mild (F0–1) or significant fibrosis (F2–4). Models were adjusted for body-mass index (BMI), age and patatin-like phospholipase domain-containing protein 3 (PNPLA3 rs738409) (I148M) genotype. A secondary analysis examined whether associations from the primary analysis could be confirmed in the corresponding plasma lipid fractions. Results: PL behenic acid (22:0) was directly associated [OR (95% CI): 1.86 (1.00, 3.45)] whereas PL docosahexaenoic acid (22:6n-3) [OR (95% CI): 0.45 (0.23, 0.89)], TAG oleic acid (18:1n-9) [OR (95% CI): 0.52 (0.28, 0.95)] and 18:1n-9 and vaccenic acid (18:1n-7) (18:1) [OR (95% CI): 0.52 (0.28, 0.96)] were inversely associated with liver fibrosis. In plasma, TAG 18:1n-9 [OR (95% CI): 0.55 (0.31, 0.99)], TAG 18:1 [OR (95% CI): 0.54 (0.30, 0.97)] and PL 22:0 [OR (95% CI): 0.46 (0.25, 0.86)] were inversely associated with liver fibrosis. Conclusion: Higher TAG 18:1n-9 levels were linked to lower fibrosis in both liver and plasma, possibly reflecting an altered fatty acid metabolism. Whether PL 22:6n-3 has a protective role, together with a potentially adverse effect of hepatic 22:0, on liver fibrosis warrants large-scale studies.
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| 6. |
- Gillberg, Linn, et al.
(författare)
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Adipose tissue transcriptomics and epigenomics in low birthweight men and controls : role of high-fat overfeeding
- 2016
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 59:4, s. 799-812
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Tidskriftsartikel (refereegranskat)abstract
- Aims/hypothesis Individuals who had a low birthweight (LBW) are at an increased risk of insulin resistance and type 2 diabetes when exposed to high-fat overfeeding (HFO). We studied genome-wide mRNA expression and DNA methylation in subcutaneous adipose tissue (SAT) after 5 days of HFO and after a control diet in 40 young men, of whom 16 had LBW. Methods mRNA expression was analysed using Affymetrix Human Gene 1.0 ST arrays and DNA methylation using Illumina 450K BeadChip arrays. Results We found differential DNA methylation at 53 sites in SAT from LBW vs normal birthweight (NBW) men (false discovery rate < 5%), including sites in the FADS2 and CPLX1 genes previously associated with type 2 diabetes. When we used reference-free cell mixture adjustments to potentially adjust for cell composition, 4,323 sites had differential methylation in LBW vs NBW men. However, no differences in SAT gene expression levels were identified between LBW and NBW men. In the combined group of all 40 participants, 3,276 genes (16.5%) were differentially expressed in SAT after HFO (false discovery rate < 5%) and there was no difference between LBW men and controls. The most strongly upregulated genes were ELOVL6, FADS2 and NNAT; in contrast, INSR, IRS2 and the SLC27A2 fatty acid transporter showed decreased expression after HFO. Interestingly, SLC27A2 expression correlated negatively with diabetes- and obesity-related traits in a replication cohort of 142 individuals. DNA methylation at 652 CpG sites (including in CDK5, IGFBP5 and SLC2A4) was altered in SAT after overfeeding in this and in another cohort. Conclusions/interpretation Young men who had a LBW exhibit epigenetic alterations in their adipose tissue that potentially influence insulin resistance and risk of type 2 diabetes. Short-term overfeeding influences gene transcription and, to some extent, DNA methylation in adipose tissue; there was no major difference in this response between LBW and control participants.
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| 7. |
- Hommel, Adrianus L.A.J., et al.
(författare)
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Optimizing Treatment in Undertreated Late-Stage Parkinsonism : A Pragmatic Randomized Trial
- 2020
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Ingår i: Journal of Parkinson's Disease. - 1877-7171. ; 10:3, s. 1171-1184
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Tidskriftsartikel (refereegranskat)abstract
- Background: Treatment of patients with late-stage parkinsonism is often sub-optimal. Objective: To test the effectiveness of recommendations by a movement disorder specialist with expertise in late-stage parkinsonism. Methods: Ninety-one patients with late-stage parkinsonism considered undertreated were included in apragmatic a pragmatic multi-center randomized-controlled trial with six-month follow-up. The intervention group received a letter with treatment recommendations to their primary clinician based on an extensive clinical assessment. Controls received care as usual. The primary outcome was the Unified Parkinson Disease Rating Scale (UPDRS)part-II (Activities of Daily Living). Other outcomes included quality-of-life (PDQ-8), mental health (UPDRS-I), motor function (UPDRS-III), treatment complications (UPDRS-IV), cognition (Mini-mental-state-examination), non-motor symptoms (Non-Motor-Symptoms-scale), health status (EQ-5D-5L) and levodopa-equivalent-daily-dose (LEDD). We also assessed adherence to recommendations. In addition to intention-to-treat analyses, a per-protocol analysis was conducted. Results: Sample size calculation required 288 patients, but only 91 patients could be included. Treating physicians followed recommendations fully in 16 (28%) and partially in 21 (36%) patients. The intention-to-treat analysis showed no difference in primary outcome (between-group difference=-1.2, p=0.45), but there was greater improvement for PDQ-8 in the intervention group (between-group difference=-3.7, p=0.02). The per-protocol analysis confirmed these findings, and showed less deterioration in UPDRS-part I, greater improvement on UPDRS-total score and greater increase in LEDD in the intervention group. Conclusions: The findings suggest that therapeutic gains may be reached even in this vulnerable group of patients with late-stage parkinsonism, but also emphasize that specialist recommendations need to be accompanied by better strategies to implement these to further improve outcomes.
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| 8. |
- Jonsson, C. E., et al.
(författare)
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High-resolution diatom d18O records from two sub-Arctic high-altitude lakes in the Swedish Scandes
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Ingår i: Journal of Quaternary Science. - 0267-8179 .- 1099-1417.
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Tidskriftsartikel (refereegranskat)abstract
- Waters from high altitude alpine lakes are mainly recharged by meteoric water. Because of seasonal variations in precipitation and temperature, and relatively short hydraulic residence times, most high altitude lakes have lake water isotopic compositions (δ18Olake) that fluctuate due to seasonality in water balance processes. Input from snowmelt, in particular, has a significant role in determining lake water d18O. Here we compare two high resolution δ18Odiatom records from lake sediments in the Swedish Scandes with instrumental data from the last century obtained from nearby meteorological stations. The time period AD 1900 to AD 1990 is characterized by an increase in winter precipitation and high winter/summer precipitation ratios and this is recorded in δ18Odiatom as decreasing trends. Lowest δ18Odiatom values and highest amount of winter precipitation are found around AD 1990 when the winter North Atlantic Oscillation index was above +2. We conclude that for the last 150 years the main factor affecting the δ18Odiatom signal in these sub-Arctic high altitude lakes with short residence times has been changes in amount of winter precipitation and that δ18Odiatom derived from high altitude lakes in the Swedish Scandes can be used as a winter precipitation proxy.
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| 9. |
- Jonsson, C. E., et al.
(författare)
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Reconstructing past atmosperic circulation changes using oxygen isotopes in lake sediments from Sweden
- 2010
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Ingår i: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 6:1, s. 49-62
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Tidskriftsartikel (refereegranskat)abstract
- Here we use lake sediment studies from Sweden to illustrate how Holocene-aged oxygen isotope records from lakes located in different hydrological settings, can provide information about climate change. In particular changes in precipitation, atmospheric circulation and water balance. We highlight the importance of understanding the present lake hydrology, and the relationship between climate variables and the oxygen isotopic composition of precipitation (d18Op)and lake waters (d18Olakewater) for interpretation of the oxygen isotopic record from the sediments (d18O). Both precipitation reconstructions from northern Sweden and water balance reconstructions from south and central Sweden show that the atmospheric circulation changed from zonal to a more meridional airflow over the Holocene. Superimposed on this Holocene trend are δ18Op minima resembling intervals of the negative phase of the North Atlantic Oscillation (NAO), thus suggesting that the climate of Northern Europe is strongly influenced by atmospheric and oceanic circulation changes over the North Atlantic.
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| 10. |
- Jonsson, C. E., et al.
(författare)
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Reconstructing past atmospheric circulation changes using oxygen isotopes in lake sediments from Sweden
- 2009
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Ingår i: Climate of the Past Discussions. - 1814-9340. ; 5:3, s. 1609-1644
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Tidskriftsartikel (refereegranskat)abstract
- Here we use lake sediment studies from Sweden to illustrate how Holocene-aged oxygen isotope records (from lakes located in different hydrological settings) can provide information about climate change. In particular changes in precipitation, atmospheric circulation and water balance. We highlight the importance of understanding the present and past lake hydrology, and the relationship between climate parameters and the oxygen isotopic composition of precipitation (d18Op) and lake waters (d18Olakewater) for interpretation of the oxygen isotopic record from the sediments (d18O). Both precipitation reconstructions from northern Sweden and water balance reconstructions from south and central Sweden show that the atmospheric circulation changed from zonal to a more meridional air flow over the Holocene. Superimposed on this Holocene trend are δ18Op minima resembling intervals of the negative phase of the North Atlantic Oscillation (NAO), thus suggesting that the climate of Northern Europe is strongly influenced by atmospheric and oceanic circulation changes over the North Atlantic.
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