| 1. |
- Critchley, Hugo D, et al.
(författare)
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Neural systems supporting interoceptive awareness.
- 2004
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Ingår i: Nat Neurosci. - : Springer Science and Business Media LLC. - 1097-6256 .- 1546-1726. ; 7:2, s. 189-95
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Tidskriftsartikel (refereegranskat)abstract
- Influential theories of human emotion argue that subjective feeling states involve representation of bodily responses elicited by emotional events. Within this framework, individual differences in intensity of emotional experience reflect variation in sensitivity to internal bodily responses. We measured regional brain activity by functional magnetic resonance imaging (fMRI) during an interoceptive task wherein subjects judged the timing of their own heartbeats. We observed enhanced activity in insula, somatomotor and cingulate cortices. In right anterior insular/opercular cortex, neural activity predicted subjects' accuracy in the heartbeat detection task. Furthermore, local gray matter volume in the same region correlated with both interoceptive accuracy and subjective ratings of visceral awareness. Indices of negative emotional experience correlated with interoceptive accuracy across subjects. These findings indicate that right anterior insula supports a representation of visceral responses accessible to awareness, providing a substrate for subjective feeling states.
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| 2. |
- Hofvander, Björn, et al.
(författare)
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Offenders with autism spectrum disorder
- 2018
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Ingår i: The Wiley Blackwell Handbook of Forensic Neuroscience. - : Wiley. - 9781118650929 - 9781118650868 ; 1-2, s. 273-299
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Bokkapitel (refereegranskat)abstract
- This chapter expresses that autism spectrum disorder (ASD) is a heterogeneous disorder where several neural networks are involved in producing the behavioral symptoms. Comorbidity in other neurodevelopmental and psychiatric disorders is a hallmark of ASD. The chapter presents an overview of the clinical and neurobiological characteristics of ASD as well as the literature on the association between ASD and offending. The integrated emotion systems model hypothesizes that deviant social behavior, such as violence, is the result of inhibited emotional development caused by dysfunction in the amygdala and other limbic system regions, like the hippocampus, hypothalamus, anterior cingulate cortex, insular cortex, and ventral striatum. Importantly, a defendant with ASD most often lacks the ability to correctly imagine, interpret, or predict others' thoughts, feelings, or behaviors and they will therefore have difficulty in understanding the consequences of their own or others' actions and are unlikely to be aware of how their behavior is interpreted by others.
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