| 1. |
- Bergman, Åke, et al.
(författare)
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Science and policy on endocrine disrupters must not be mixed : a reply to a "common sense" intervention by toxicology journal editors
- 2013
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Ingår i: Environmental Health. - : BioMed Central (BMC). - 1476-069X. ; 12
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Tidskriftsartikel (refereegranskat)abstract
- The "common sense" intervention by toxicology journal editors regarding proposed European Union endocrine disrupter regulations ignores scientific evidence and well-established principles of chemical risk assessment. In this commentary, endocrine disrupter experts express their concerns about a recently published, and is in our considered opinion inaccurate and factually incorrect, editorial that has appeared in several journals in toxicology. Some of the shortcomings of the editorial are discussed in detail. We call for a better founded scientific debate which may help to overcome a polarisation of views detrimental to reaching a consensus about scientific foundations for endocrine disrupter regulation in the EU.
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| 2. |
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| 3. |
- Caporale, N., et al.
(författare)
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From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures
- 2022
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 375:6582
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Tidskriftsartikel (refereegranskat)abstract
- Convergent evidence associates exposure to endocrine disrupting chemicals (EDCs) with major human diseases, even at regulation-compliant concentrations. This might be because humans are exposed to EDC mixtures, whereas chemical regulation is based on a risk assessment of individual compounds. Here, we developed a mixture-centered risk assessment strategy that integrates epidemiological and experimental evidence. We identified that exposure to an EDC mixture in early pregnancy is associated with language delay in offspring. At human-relevant concentrations, this mixture disrupted hormone-regulated and disease-relevant regulatory networks in human brain organoids and in the model organisms Xenopus leavis and Danio rerio, as well as behavioral responses. Reinterrogating epidemiological data, we found that up to 54% of the children had prenatal exposures above experimentally derived levels of concern, reaching, for the upper decile compared with the lowest decile of exposure, a 3.3 times higher risk of language delay. © 2022 American Association for the Advancement of Science. All rights reserved.
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| 4. |
- Aidas, Kestutis, et al.
(författare)
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The Dalton quantum chemistry program system
- 2014
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Ingår i: WIREs Computational Molecular Science. - : Wiley. - 1759-0876 .- 1759-0884. ; 4:3, s. 269-284
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Tidskriftsartikel (refereegranskat)abstract
- Dalton is a powerful general-purpose program system for the study of molecular electronic structure at the Hartree-Fock, Kohn-Sham, multiconfigurational self-consistent-field, MOller-Plesset, configuration-interaction, and coupled-cluster levels of theory. Apart from the total energy, a wide variety of molecular properties may be calculated using these electronic-structure models. Molecular gradients and Hessians are available for geometry optimizations, molecular dynamics, and vibrational studies, whereas magnetic resonance and optical activity can be studied in a gauge-origin-invariant manner. Frequency-dependent molecular properties can be calculated using linear, quadratic, and cubic response theory. A large number of singlet and triplet perturbation operators are available for the study of one-, two-, and three-photon processes. Environmental effects may be included using various dielectric-medium and quantum-mechanics/molecular-mechanics models. Large molecules may be studied using linear-scaling and massively parallel algorithms. Dalton is distributed at no cost from for a number of UNIX platforms.
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| 5. |
- Anagrius, C, et al.
(författare)
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HIV testing in Swedish STD clinics 1986-1994
- 1998
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Ingår i: International journal of STD & AIDS. - : SAGE Publications. - 0956-4624 .- 1758-1052. ; 9:8, s. 457-462
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Tidskriftsartikel (refereegranskat)abstract
- In 1986 Swedish STD clinicians decided on a national policy of offering HIV tests routinely to all their patients. During the period July 1986 through December 1994, 224,722 tests were performed. HIV tests for one or more specific reasons were carried out on 7 of the patients, and 20 requested the test solely because of anxiety. The remaining 73 , accepted the test as part of the clinical routine without giving any specific reason. Of those offered a test, 54 had been tested at least once before. Twenty three per cent did not accept the test. Among those tested, 373 persons 0.2 were found to have a newly detected HIV infection. Contact tracing was the reason for testing in 11 , whilst 32 were tested for other specific reasons, 29 requested testing for no stated specific reason and 28 had been tested as a routine. Of all the tested men who reported sex with men, 7 proved to be HIV positive. The 373 persons with newly detected HIV infection constituted 14 of the total newly detected cases in Sweden during the period in question.
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| 7. |
- Ingre-Khans, E, et al.
(författare)
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Reliability and relevance evaluations of REACH data
- 2019
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Ingår i: Toxicology research. - : Oxford University Press (OUP). - 2045-452X .- 2045-4538. ; 8:1, s. 46-56
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Tidskriftsartikel (refereegranskat)abstract
- This study highlights that the procedures for evaluating data under REACH and reporting these evaluations are neither systematic nor transparent.
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| 9. |
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| 10. |
- Mie, A, et al.
(författare)
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Correction to: Response to Juberg et al
- 2020
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Ingår i: Environmental health : a global access science source. - : Springer Science and Business Media LLC. - 1476-069X. ; 19:1, s. 76-
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- An amendment to this paper has been published and can be accessed via the original article.
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