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- Glasbey, JC, et al.
(författare)
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- 2021
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swepub:Mat__t
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- Tabiri, S, et al.
(författare)
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- 2021
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swepub:Mat__t
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- Bravo, L, et al.
(författare)
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- 2021
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swepub:Mat__t
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- Madrigal-Ruiz, P. M., et al.
(författare)
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The unbalance of adiponectin oligomers, RvE1 and chemerin levels are associate with increase of adiposopathy status and insulin resistance in obesity
- 2019
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Ingår i: Journal of Translational Science. - : Open Access Text. - 2059-268X. ; 5
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Objective: The aim was to establish if the balance adiponectin-oligomers, resolvin-E1 and chemerin levels could contribute to the insulin resistance (IR) setting of subjects with obesity, based on their serum levels and its relationship with inflammatory markers, metabolic profile and adiposopathy status.Methods: This study included 230 individuals, classified according to World Health Organization criteria by body mass index (BMI) kg/m2 in two groups: without-obesity (from 18.5 to 29.9) and with-obesity (from 30.0 to 39.9). Body fat mass distribution, metabolic and inflammatory markers were measured by anthropometric, enzymatic and immuno-turbidimetry methods, respectively. Serum insulin, resolvin-E1, chemerin, and adiponectin-oligomers were evaluating by ELISA method. Analysis performed were correlations IR-indexes with adiposity, receiver operating characteristic (ROC) curves and the adiponectin-oligomers, resolvin-E1 and chemerin tertiles.Results: Subjects’ with-obesity showed adiposopathy status, characterized by metabolic dysregulation and a subclinical inflammatory profile. They presented higher levels (`x ±SD, ng/mL) of resolvin-E1 (1227 ±668 versus 909 ±769, P= 0.017), chemerin (91 ±31 versus 79 ±23, P= 0.013) and LMW-Adiponectin (2257 ±797 versus 1030 ±1055, P= 0.011), whereas HMW-Adiponectin was lower (2470 ±1095 versus 3236 ±1848, P= 0.010), compared to the without-obesity individuals. Individuals’ with-obesity also displayed positive correlation of IR markers (rho from 0.163 to 0.479) along body fat measurements, metabolic and inflammation profiles. Moreover, a negative correlation of HMW-Adiponectin (rho from –0.564 to –0.214) with body fat measurements, metabolic and inflammation profiles. IR-indexes, LMW-Adiponectin and resolvin-E1/chemerin relationship showed differences between groups’ with-obesity and without-obesity, but not with gender. ROC curves shown potential ability of the LMW-Adiponectin levels to differentiate IR from non-IR individuals, with AUC of 0.815, P<0.0001 (95%, CI: 0.726-0.903).Conclusion: The present study shown that LMW-Adiponectin-resolvinE1-chemerin serum unbalance establishes a specific relationship with adiposopathy in individuals with obesity, which could be a way to identify risk factors in early stages of IR.
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- Ahlborg, Helene, 1980, et al.
(författare)
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Bringing Technology into Social-Ecological Systems ResearchMotivations for a Socio-Technical-Ecological Systems Approach
- 2019
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Ingår i: Sustainability. - : MDPI AG. - 2071-1050. ; 11:7
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Tidskriftsartikel (refereegranskat)abstract
- The purpose of this synthesis paper is to present the motivations and conceptual basis for research on socio-technical-ecological systems (STES), addressing the need for interdisciplinary studies targeting the technological mediation of human-environment relationships. The background is the very limited number of collaborations between scholars of social-ecological systems and sociotechnical systems (SES), despite repeated calls for bridging work. The synthesis builds on an in-depth review of previous literature, interdisciplinary exchanges, and empirical examples. The result is arguments for why a sociotechnical understanding of technology' is of central importance for SES studies, related to how technology: (1) mediates human-environment relationships; (2) brings ambivalence to these relationships; (3) enhances and transforms human agency and provides a source of constitutive power; (4) changes scalar relationships, enabling our interaction with and impact on the natural world across time and space. Furthermore, we present an STES analytical approach which starts from symmetrical attention to technology, society, and environment, specifically targeting interfaces and relationships of critical relevance for SES scholars, and address counterarguments that we have encountered. We conclude that a shift to STES research will enhance our knowledge of system interfaces that are often overlooked, opening further avenues for research and real-world interventions.
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