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| 2. |
- Jansson, T, et al.
(författare)
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Automated correction of linear deformation due to sectioning in serial micrographs.
- 1995
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Ingår i: Journal of microscopy. - 0022-2720. ; 177:Pt 2, s. 119-27
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes an objective and automatic method for detection and correction of sectioning deformations in digitized micrographs, as well as an evaluation of the method applied to light and electron microscopic images of semi-thin and ultra-thin serial sections from brain cortex. The detection is based on matching of image subregions and the deformation model is bi-linear, i.e. two first-order polynomials are used for modelling compression/expansion in perpendicular directions. The procedure is applicable to prealigned serial two-dimensional sections and is primarily aimed at three-dimensional reconstruction of tissue samples consisting of a large number of cells with random distribution and morphology.
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| 5. |
- Pascher, R, et al.
(författare)
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Computer-assisted 3D analysis of cell distributions in the normal and epileptic cerebral cortex: description of a methodology in progress.
- 1993
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Ingår i: Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society. - 0895-6111. ; 17:4-5, s. 405-10
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Tidskriftsartikel (refereegranskat)abstract
- This paper describes software routines that (a) visualizes a stack of several thousands of aligned sequential photographic two-dimensional (2D) images stored in an image processing system; (b) creates a data base containing information about objects identified sequentially from the 2D images; (c) transfers the data base to a graphical terminal; (d) reconstructs a three-dimensional (3D) object space; and (e) supports on-line interaction between the image processing system and the graphical terminal. As an application example, the cell content of a prism of motor cerebral cortex of the cat is reconstructed. Preliminary results from reconstructing human epileptic temporal cortex (cortical microdysgenesia) are also reported.
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| 6. |
- Petersson, Göran, et al.
(författare)
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Medicinsk informatik
- 1996
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Bok (övrigt vetenskapligt/konstnärligt)
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| 7. |
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| 8. |
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| 9. |
- Skoglund, Thomas, 1969, et al.
(författare)
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3D reconstruction of biological objects from sequential image planes--applied on cerebral cortex from cat.
- 1993
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Ingår i: Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society. - 0895-6111. ; 17:3, s. 165-74
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Tidskriftsartikel (refereegranskat)abstract
- A prism of cat cerebral cortex was reconstructed with a method for three-dimensional (3D) representation of biological objects. A series of 918 semithin sections were digitized into an image analysis system. The images were aligned and analyzed, and a data base with the coordinates and a classification of the cells was created. The data base (i.e., the cortical prism) was visualized in a 3D graphic terminal, and parameters such as columnar and lamellar organization, clustering, and cell density were analyzed. A neuronal perikaryon and its neurites was reconstructed and shown together with the cortical prism.
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| 10. |
- Stalfors, Joacim, 1966, et al.
(författare)
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Haptic palpation of head and neck cancer patients--implication for education and telemedicine.
- 2001
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Ingår i: Studies in health technology and informatics. - 0926-9630. ; 81, s. 471-4
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Tidskriftsartikel (refereegranskat)abstract
- Malignancy in the head and neck area is a disease that often gives high morbidity in functions like speech, eating, breathing and cosmetics. To ensure a treatment of high clinical standard these patients are presented for a multidisciplinary tumor-team at Sahlgren University hospital. The team usually involves ENT-surgeons (Ear, Nose and Throat), oncologists, radiologists, pathologists, plastic surgeon, general surgeon and oral surgeons. The aim of the presentation is to classificate the tumor and suggests a treatment. The patients presented are from the whole western region of Sweden, and therefore some patients have to travel long distances. To minimize travel telemedicine was introduced 1998 with success [1]. One concern, when presenting a patient with telemedicine, has been the lack of possibility to palpate the tumor and the tissue surrounding it. To address this problem a 3D model of the tumor visualizes the region and possibly allows haptic palpation. Based on a series of high resolution CT/MR scans, a model of the region around the patients tumor is created. Haptic properties are added to the skin and subcutaneous structures (including the tumor) of the model. Initially, the haptic tuning is done by an examining physician, but in the final telemedical application, the aim is to develop a sensory device for this purpose (e.g. a position sensitive glove, such as Virtual Technologies, Inc. CyberGlove [2] and a graded system for setting firmness of the tissue). The model with its haptic properties can then be examined visually and haptically, the latter using a haptic device such as the SensAble PHANToM [3]. The present system uses a 3D model in VRML format based on reconstructed structures in the ROI (which includes the jawbones, the vertebra, the throat, major muscles and the skin) from high resolution CT. Haptic properties are added using MAGMA 2.5 (ReachIn Technologies AB, Sweden) [4]. Haptic force feedback is provided using a PHANToM Desktop (SensAble Technologies Inc) [3]. Visual feedback can be either monoscopic or stereoscopic (StereoGraphic CrystalEyes) [5]. The system will be used for concept testing and for evaluating possible limitations and/or the need for a modified examination protocol. Once a reliable set of parameters has been generated (using both professionals and medical students at various levels), the remote components will be added.
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