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- Riihijarvi, Sari, et al.
(författare)
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High serum vascular endothelial growth factor level is an adverse prognostic factor for high-risk diffuse large B-cell lymphoma patients treated with dose-dense chemoimmunotherapy
- 2012
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Ingår i: European Journal of Haematology. - : Wiley. - 1600-0609 .- 0902-4441. ; 89:5, s. 395-402
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Tidskriftsartikel (refereegranskat)abstract
- Objectives To determine whether serum vascular endothelial growth factor (s-VEGF) levels and VEGF gene expression in tumor tissue predict survival of diffuse large B-cell lymphoma (DLBCL) patients treated with chemoimmunotherapy. Methods VEGF levels were measured in serum samples from 102 patients <65yrs with high-risk DLBCL using a quantitative sandwich enzyme immunoassay technique. Exon array data set of tumor tissues from 32 patients was concurrently used to determine VEGF-A exon and gene expression. All patients were treated in a Nordic phase II study with six dose-dense chemoimmunotherapy courses followed by systemic central nervous system prophylaxis. Results After a median follow-up time of 40months, 3-yr progression-free survival (PFS) was inferior in patients with high s-VEGF levels compared to those with low levels (59% vs. 83%, P=0.005). The relative risk of progression or relapse was 3.1-fold (95% confidence interval 1.346.91, P=0.008). The predictive capacity of s-VEGF levels on PFS was most pronounced in the DLBCLs of non-germinal center subtype. In contrast to serum data, VEGF mRNA expression in the lymphoma tissue did not predict outcome, and no correlation was found between s-VEGF levels and lymphoma VEGF expression. Conclusion Pretreatment s-VEGF level is a predictor of PFS after chemoimmunotherapy and may help to further stratify high-risk DLBCL patients into low- and high-risk groups.
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| 2. |
- Takahashi, H., et al.
(författare)
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Beam test results of the polarized gamma-ray observer, PoGOLite
- 2008
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Ingår i: 2008 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (2008 NSS/MIC), VOLS 1-9. - 9781424427147 ; , s. 732-736
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Konferensbidrag (refereegranskat)abstract
- The Polarized Gamma-ray Observer, PoGOLite, is a balloon experiment with the capability of detecting 10% polarization from a 200 mCrab celestial object in the energy range 25 #x2013;80 keV. During a beam test at KEK-PF in February 2008, 20 detector units were assembled, and a 50 keV X-ray beam with a polarization degree of #x223C;90% was irradiated at the center unit. Signals from all 20 units were fed into flightversion electronics consisting of six circuit boards (four waveform digitizer boards, one digital I/O board and one router board) and one microprocessor (SpaceCube), which communicate using a SpaceWire interface. One digitizer board, which can associate up to 8 PDCs, outputs a trigger signal. The digital I/O board handles the trigger and returns a data acquisition request if there is no veto signal (upper or pulse-shape discriminators) from any detector unit. This data acquisition system worked well, and the modulation factor was successfully measured to be #x223C;34%. These results confirmed the capabilities of both detector and data-acquisition system for a pathfinder flight planned in 2010.
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