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- Caporale, N., et al.
(författare)
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From cohorts to molecules: Adverse impacts of endocrine disrupting mixtures
- 2022
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 375:6582
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Tidskriftsartikel (refereegranskat)abstract
- Convergent evidence associates exposure to endocrine disrupting chemicals (EDCs) with major human diseases, even at regulation-compliant concentrations. This might be because humans are exposed to EDC mixtures, whereas chemical regulation is based on a risk assessment of individual compounds. Here, we developed a mixture-centered risk assessment strategy that integrates epidemiological and experimental evidence. We identified that exposure to an EDC mixture in early pregnancy is associated with language delay in offspring. At human-relevant concentrations, this mixture disrupted hormone-regulated and disease-relevant regulatory networks in human brain organoids and in the model organisms Xenopus leavis and Danio rerio, as well as behavioral responses. Reinterrogating epidemiological data, we found that up to 54% of the children had prenatal exposures above experimentally derived levels of concern, reaching, for the upper decile compared with the lowest decile of exposure, a 3.3 times higher risk of language delay. © 2022 American Association for the Advancement of Science. All rights reserved.
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| 3. |
- Hodge, B. -MS., et al.
(författare)
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Addressing technical challenges in 100% variable inverter-based renewable energy power systems
- 2020
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Ingår i: Wiley Interdisciplinary Reviews. - : John Wiley and Sons Ltd. - 2041-8396 .- 2041-840X. ; 9:5
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Tidskriftsartikel (refereegranskat)abstract
- Rapidly increasing levels of variable inverter-based renewable energy sources (are quickly changing electric power systems and prompting questions about how the systems will be operated when renewable generation becomes the dominant technologies. In this article, we review the status of this shifting paradigm in power systems throughout the world. We then review the implications of this shift, focusing on the rising challenges, and we provide an overview and technology-readiness classifications of some proposed mitigation strategies. Finally, we highlight outstanding questions that will require solutions to reach these ultrahigh shares of variable inverter-based renewable energy sources.
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| 4. |
- Holttinen, H., et al.
(författare)
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Design and operation of power systems with large amounts of wind power
- 2009
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Bok (refereegranskat)abstract
- There are already several power systems coping with large amounts of wind power. Hi h penetration of wind power has impacts that have to be manage through proper plant interconnection, integration, transmission planning, and system and market operations. This report is a summary of case studies addressing concerns about the impact of wind power.s variability and uncertainty on power system reliability and costs. The case studies summarized in this report are not easy to compare due to different methodology and data used, as well as different assumptions on the interconnection capacity available. Integration costs of wind power need to be compared to something, like the production costs or market value of wind power, or integration cost of other production forms. There is also benefit when adding wind power to power systems: it reduces the total operating costs and emissions as wind fossil fuels. Severalissues that impact on the amount of wind power that can be integrated have been identified. Large balancing areas and aggregation benefits of large areas help in reducing the variability and forecast errors of wind power as well as help in pooling more cost effective balancing resources. System operation and working electricity markets at less than day-ahead time scales help reduce forecast errors of wind power. Transmission is the key to aggregation benefits, electricity markets and larger balancing areas. From the investigated studies it follows that at wind penetrations of up to 20 % of gross demand (energy), system operating cost increases arising from wind variability and uncertainty amounted to about 1.4 ./MWh. This is 10 % or less of the wholesale value of the wind energy.
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| 6. |
- Julkunen-Iivari, A, et al.
(författare)
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Tobacco Products, Periodontal Health and Education Level: Cohort Study from Sweden
- 2020
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Ingår i: Dentistry journal. - : MDPI AG. - 2304-6767. ; 8:3
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Tidskriftsartikel (refereegranskat)abstract
- Background: The aim of this study is to investigate if using tobacco products (including snuff, smoking tobacco and dual-using) associates with periodontal health, education level and mortality in a Swedish cohort, hypothesizing that tobacco products affect periodontal health, associate with lower education and increase the risk of death. Method: Study cohort of 1080 subjects aged 31–40 years (528 men, 552 women) was clinically examined and interviewed in 1985 and followed for mortality until 2015. Subjects were classified into two groups: “tobacco users” and “non-users”. Associations between periodontal health parameters, tobacco products, education level and age of death were analysed. SPSS was used for analyses. Results: Tobacco products, as well as education level associated, with poor periodontal health. Tobacco users and lower education was linked to higher plaque-, calculus- and gingival-index scores than non-users (p < 0.001). They also had significantly higher prevalence of deep periodontal pockets (≥5 mm) (p < 0.001 and 0.010, respectively), missing teeth (p = 0.010 and 0.003, respectively) and lower education level (p < 0.001) compared with non-users. However, tobacco product users did not die significantly earlier than non-users. Conclusion: Tobacco products had a negative impact on periodontal health. Tobacco product users were less educated. However, using tobacco products may not cause premature death.
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| 9. |
- Holttinen, H., et al.
(författare)
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Design and operation of power systems with large amounts of wind power production, IEA collaboration
- 2006
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Ingår i: European Wind Energy Conference and Exhibition 2006. - 9781622764679 ; , s. 156-165
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Konferensbidrag (refereegranskat)abstract
- New R&D collaboration on "Design and Operation of Power Systems with Large Amounts of Wind Power Production" has been formed in IEA Wind. The R&D task will collect and share information on the experience gained and the studies made on power system impacts of wind power, and review methodologies, tools and data used. This paper outlines the power system impacts of wind power, the national studies published and on-going and describes the goals of the international collaboration. There are dozens of studies made and ongoing related to cost of wind integration, however, the results are not easy to compare. An in-depth review of the studies is needed to draw conclusions on the range of integration costs for wind power. State-of-the art review process will seek for reasons behind the wide range of results for costs of wind integration - definitions for wind penetration, reserves and costs; different power system and load characteristics and operational rules; underlying assumptions on variability of wind etc.
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