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- Rönnholm, Petra, 1969, et al.
(författare)
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Improved and efficient synthesis of chiral N,P-Ligands via cyclic sulfamidates for asymmetric addition of butyllithium to benzaldehyde
- 2007
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Ingår i: Organic Letters. - : American Chemical Society (ACS). - 1523-7060 .- 1523-7052. ; 9:19, s. 3781-3783
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Tidskriftsartikel (refereegranskat)abstract
- A robust and scaleable route to chiral 1-isopropylamino-2-(diphenylphosphino)ethanes is described via the ring-opening of chiral, cyclic sulfamidates with potassium diphenylphosphide (KPPh2). The novel protocol offers a robust access to gram quantities of chiral amino phosphinoethanes in high yields. The Li-amides of the chiral aminophosphines were evaluated as chiral ligands in the asymmetric addition of n-butyllithium (BuLi) to benzaldehyde, yielding 1-phenylpentanol up to 98% ee.
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- Sandell, Mikael, et al.
(författare)
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A novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation : a blinded study
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- Inherent to any stenting procedure is the prescription of dual antiplatelet therapy (DAPT) to reduce the platelet response. Clinical guidelines recommend 6 - 12 months of DAPT, depending on stent type, clinical picture and patient factors. Our hypothesis is that a nanostructured noble metal coating has the potential to reduce protein deposition and platelet activation, which in turn could reduce the need for DAPT. Here, a noble metal nanostructure coating on stents is investigated. Twelve pigs underwent endovascular implantation of coated and non-coated stents for paired comparisons in a double-blinded study design. The non-coated control stent was placed at the contralateral corresponding artery. Volumetric analysis of angiographic data, performed by a treatment blinded assessor, demonstrated a significant thrombus reduction for one of the coatings compared to control. This effect was already seen one hour after implantation. This finding was supported by in vitro data showing a significant reduction of coagulation activation in the coated group. This novel coating shows promise as an implant material addition and could potentially decrease the need for DAPT in the acute clinical setting.
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- Sandell, Mikael, et al.
(författare)
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A novel noble metal stent coating reduces in vitro platelet activation and acute in vivo thrombosis formation : a blinded study
- 2023
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Ingår i: Scientific Reports. - : Springer Nature. - 2045-2322. ; 13:1
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Tidskriftsartikel (refereegranskat)abstract
- Inherent to any stenting procedure is the prescription of dual antiplatelet therapy (DAPT) to reduce the platelet response. Clinical guidelines recommend 6–12 months of DAPT, depending on stent type, clinical picture and patient factors. Our hypothesis is that a nanostructured noble metal coating has the potential to reduce protein deposition and platelet activation. These effects would reduce subsequent thrombo-inflammatory reactions, potentially mitigating the need for an extensive DAPT in the acute phase. Here, a noble metal nanostructure coating on stents is investigated. Twelve pigs underwent endovascular implantation of coated and non-coated stents for paired comparisons in a blinded study design. The non-coated control stent was placed at the contralateral corresponding artery. Volumetric analysis of angiographic data, performed by a treatment blinded assessor, demonstrated a significant thrombus reduction for one of the coatings compared to control. This effect was already seen one hour after implantation. This finding was supported by in vitro data showing a significant reduction of coagulation activation in the coated group. This novel coating shows promise as an implant material addition and could potentially decrease the need for DAPT in the early phases of stent implementation.
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- Södergren, Mikael J.
(författare)
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Allylic alcohols and aziridines from alkenes : Studies in asymmetric catalysis
- 2000
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The development of methodology for asymmetric catalytic transformation of alkenederivatives is summarized. The studies concern the [a] Cu(I)-catalyzed allylic oxidation,[b] isomerization of epoxides to allyl alcohols, and [c] Cu(I)-catalyzed alkeneaziridination, respectively.[a] The preparation of exo-2-azabicyclo[2.2.1]heptane-3-carboxylic acid 7a is described, along with its application as ligand for the allylic oxidation of cyclopentene and cyclohexene with peresters. The use of 7a resulted in higher yields and levels of asymmetric induction compared to those obtained with (L)-proline, and gave the corresponding 2-cycloalkenyl benzoates of 65% ee, in up to 63% yield.[b] Diamines 15 and 39 were prepared and evaluated as catalysts for the base-mediated rearrangement of meso- and racemic epoxides. Treatment of epoxides with stoichiometric amounts of lithium diisopropylamide and 5 mol% of (1S, 3R, 4R)-3-(1-pyrrolidinyl)methyl-2-azabicyclo[2.2.1]heptane 15a or (2R, 5R)-methylpyrrolidinyl analogue 34b gave the corresponding allylic alcohols in good yields and with excellent enantioselectivity. An average of 95% enantiomeric excess (ee) was achieved in the synthesis of 12 allylic alcohols, several of which are valuable precursors to pharmaceuticals and natural products. Studies of non-linear effects indicate that the reactive species is a monomeric Li-15a, and that the formation of less reactive di- or oligomers is effectively suppressed by the presence of Lewis basic co-solvents.[c] A set of [N-(4-R-benzenesulfonyl)imino]phenyliodinanes 41a-h were evaluated as nitrene precursors for the alkene aziridination. For six out of seven alkenes studied, 41b or c (R=OMe, NO2) gave higher yields and enantioselectivity than those obtained with the commonly used 41a (R=CH3).
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