| 1. |
- Bosnic-Anticevich, S, et al.
(författare)
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ARIA pharmacy 2018 "Allergic rhinitis care pathways for community pharmacy"
- 2019
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Ingår i: Allergy. European Journal of Allergy and Clinical Immunology. - : Wiley. - 0105-4538 .- 1398-9995. ; 74:7, s. 1219-1236
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Forskningsöversikt (refereegranskat)abstract
- Pharmacists are trusted health professionals. Many patients use over-the-counter (OTC) medications and are seen by pharmacists who are the initial point of contact of allergic rhinitis management in most countries. The role of pharmacists in integrated care pathways (ICPs) for allergic diseases is important. This paper builds on existing studies and provides tools intended to help pharmacists provide optimal advice/interventions/strategies to patients with rhinitis. The ARIA-pharmacy ICP includes a diagnostic questionnaire specifically focusing attention on key symptoms and markers of the disease, a systematic Diagnosis Guide (including differential diagnoses) and a simple flowchart with proposed treatment for rhinitis and asthma multimorbidity. Key prompts for referral within the ICP are included. The use of technology is critical to enhance the management of AR. However, the ARIA-pharmacy ICP should be adapted to local health care environments/situations as regional (national) differences exist in pharmacy care.
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| 2. |
- Ernst, R. E., et al.
(författare)
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Long-lived connection between southern Siberia and northern Laurentia in the Proterozoic
- 2016
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Ingår i: Nature Geoscience. - : Springer Science and Business Media LLC. - 1752-0894 .- 1752-0908. ; 9:6, s. 464-469
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Tidskriftsartikel (refereegranskat)abstract
- Precambrian supercontinents Nuna-Columbia (1.7 to 1.3 billion years ago) and Rodinia (1.1 to 0.7 billion years ago) have been proposed. However, the arrangements of crustal blocks within these supercontinents are poorly known. Huge, dominantly basaltic magmatic outpourings and intrusions, covering up to millions of square kilometres, termed Large Igneous Provinces, typically accompany (super) continent breakup, or attempted breakup and offer an important tool for reconstructing supercontinents. Here we focus on the Large Igneous Province record for Siberia and Laurentia, whose relative position in Nuna-Columbia and Rodinia reconstructions is highly controversial. We present precise geochronology - nine U-Pb and six Ar-Ar ages - on dolerite dykes and sills, along with existing dates from the literature, that constrain the timing of emplacement of Large Igneous Province magmatism in southern Siberia and northern Laurentia between 1,900 and 720 million years ago. We identify four robust age matches between the continents 1,870, 1,750, 1,350 and 720 million years ago, as well as several additional approximate age correlations that indicate southern Siberia and northern Laurentia were probably near neighbours for this 1.2-billion-year interval. Our reconstructions provide a framework for evaluating the shared geological, tectonic and metallogenic histories of these continental blocks.
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| 3. |
- Evans, D. A D, et al.
(författare)
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Return to Rodinia? Moderate to high palaeolatitude of the São Francisco/Congo craton at 920 Ma
- 2015. - 1
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Ingår i: Geological Society Special Publication. - 0305-8719. ; 424:1, s. 167-190
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Bokkapitel (refereegranskat)abstract
- Moderate to high palaeolatitudes recorded in mafic dykes, exposed along the coast of Bahia, Brazil, are partly responsible for some interpretations that the São Francisco/Congo craton was separate from the low-latitude Rodinia supercontinent at about 1050 Ma. We report new palaeomagnetic data that replicate the previous results. However, we obtain substantially younger U-Pb baddeleyite ages from five dykes previously thought to be 1.02-1.01 Ga according to the 40Ar/39Ar method. Specifically, the so-called «A-normal» remanence direction from Salvador is dated at 924.2±3.8 Ma, within error of the age for the «C» remanence direction at 921.5±4.3 Ma. An «A-normal» dyke at Ilh»us is dated at 926.1±4.6 Ma, and two «A-normal» dykes at Olivença have indistinguishable ages with best estimate of emplacement at 918.2±6.7 Ma. We attribute the palaeomagnetic variance of the «A-normal» and «C» directions to lack of averaging of geomagnetic palaeosecular variation in some regions. Our results render previous 40Ar/39Ar ages from the dykes suspect, leaving late Mesoproterozoic palaeolatitudes of the São Francisco/Congo craton unconstrained. The combined «A-normal» palaeomagnetic pole from coastal Bahia places the São Francisco/Congo craton in moderate to high palaeolatitudes at c. 920 Ma, allowing various possible positions of that block within Rodinia.
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| 4. |
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| 5. |
- Gumsley, Ashley P., et al.
(författare)
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Timing and tempo of the Great Oxidation Event
- 2017
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 114:8, s. 1811-1816
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Tidskriftsartikel (refereegranskat)abstract
- The first significant buildup in atmospheric oxygen, the Great Oxidation Event (GOE), began in the early Paleoproterozoic in association with global glaciations and continued until the end of the Lomagundi carbon isotope excursion ca. 2,060 Ma. The exact timing of and relationships among these events are debated because of poor age constraints and contradictory stratigraphic correlations. Here, we show that the first Paleoproterozoic global glaciation and the onset of the GOE occurred between ca. 2,460 and 2,426 Ma, ∼100 My earlier than previously estimated, based on an age of 2,426 ± 3 Ma for Ongeluk Formation magmatism from the Kaapvaal Craton of southern Africa. This age helps define a key paleomagnetic pole that positions the Kaapvaal Craton at equatorial latitudes of 11° ± 6° at this time. Furthermore, the rise of atmospheric oxygen was not monotonic, but was instead characterized by oscillations, which together with climatic instabilities may have continued over the next ∼200 My until ≤2,250-2,240 Ma. Ongeluk Formation volcanism at ca. 2,426 Ma was part of a large igneous province (LIP) and represents a waning stage in the emplacement of several temporally discrete LIPs across a large low-latitude continental landmass. These LIPs played critical, albeit complex, roles in the rise of oxygen and in both initiating and terminating global glaciations. This series of events invites comparison with the Neoproterozoic oxygen increase and Sturtian Snowball Earth glaciation, which accompanied emplacement of LIPs across supercontinent Rodinia, also positioned at low latitude.
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| 6. |
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| 7. |
- Hayes, A., et al.
(författare)
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A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts
- 2020
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Ingår i: Journal of Medical Virology. - : Wiley. - 0146-6615 .- 1096-9071. ; 92:8, s. 1065-1074
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Tidskriftsartikel (refereegranskat)abstract
- Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate sample types and high assay sensitivity as viral loads in cerebrospinal fluid samples from meningitis and sepsis clinical presentation can be extremely low. This study evaluated the sensitivity and specificity of currently used commercial and in-house diagnostic and typing assays. Accurately quantified RNA transcript controls were distributed to 27 diagnostic and 12 reference laboratories in 17 European countries for blinded testing. Transcripts represented the four human EV species (EV-A71, echovirus 30, coxsackie A virus 21, and EV-D68), HPeV3, and specificity controls. Reported results from 48 in-house and 15 commercial assays showed 98% detection frequencies of high copy (1000 RNA copies/5 µL) transcripts. In-house assays showed significantly greater detection frequencies of the low copy (10 copies/5 µL) EV and HPeV transcripts (81% and 86%, respectively) compared with commercial assays (56%, 50%; P = 7 × 10−5). EV-specific PCRs showed low cross-reactivity with human rhinovirus C (3 of 42 tests) and infrequent positivity in the negative control (2 of 63 tests). Most or all high copy EV and HPeV controls were successfully typed (88%, 100%) by reference laboratories, but showed reduced effectiveness for low copy controls (41%, 67%). Stabilized RNA transcripts provide an effective, logistically simple and inexpensive reagent for evaluation of diagnostic assay performance. The study provides reassurance of the performance of the many in-house assay formats used across Europe. However, it identified often substantially reduced sensitivities of commercial assays often used as point-of-care tests.
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| 8. |
- Kastek, N., et al.
(författare)
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U-Pb Geochronology and Geochemistry of the Povungnituk Group of the Cape Smith Belt : Part of a Craton-Scale Circa 2.0 Ga Minto-Povungnituk Large Igneous Province, Northern Superior Craton
- 2018
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Ingår i: Lithos. - : Elsevier BV. - 0024-4937. ; 320-321, s. 315-331
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Tidskriftsartikel (refereegranskat)abstract
- Magmatism of the Povungnituk Group of the Cape Smith Belt, northern Superior craton, was formed in three stages: (i)early alkaline magmatism and associated carbonatites (undated), (ii) a main flood basalt sequence (Beauparlant Formation) (constrained between 2040 and 1991 Ma), and (iii) a late stage alkaline pulse (Cecilia Formation) (ca. 1959 Ma). We suggest that the main stage of magmatic activity (middle pulse) was of short duration. A new U–Pb baddeleyite age of 1998 ± 6 Ma is obtained from a dolerite sill intruding the uppermost section of the Beauparlant Formation. This age has regional significance because it matches the previously obtained 1998 ± 2 Ma age for the Watts Group (Purtuniq) ophiolite of the northern Cape Smith Belt and the 1998 ± 2 Ma U-Pb age of the Minto dykes intruding the craton to the south. These coeval units, along with additional units correlated on paleomagnetic grounds (Eskimo Formation), are interpreted to define a large igneous province (LIP), extending over an area of >400,000 km2, which we herein define as the Minto-Povungnituk LIP. Geochemical comparison between the Watts Group ophiolite, Minto dykes and the mafic Povungnituk Group shows significant differences allowing these data to be divided into two groups and domains within the LIP. A northern domain, comprising the Povungnituk and Watts groups, shows mixing between a depleted mantle source and a more enriched mantle plume-sourced melt. A southern domain comprising the Minto dykes and the paleomagnetically linked Eskimo Formation shows signs of an even more enriched source, while these magmas also show the effect of crustal contamination. Two distinct source mechanisms can be responsible for the observed geochemical differences between the two domains. First, a difference in lithospheric sources, where melting of different portions of Superior craton lithosphere caused the different melt signatures in the interior of the craton. In this case magmatism in the two domains is only related by having the same heat source (e.g.,a mantle plume) interpreted to be located on the northwestern side of the northern Superior craton. Second, two distinct deep mantle sources that remained separated within the ascending plume. This is analogous to some current hotspots interpreted to sample both large low shear velocity provinces (LLSVP) and adjacent ambient deep mantle. This latter interpretation would allow for the use of bilateral chemistry in LIPs as a potential tool for the recognition and mapping of the LLSVP boundaries throughout Earth's history.
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| 9. |
- Lindstedt, B A, et al.
(författare)
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Use of multilocus variable-number tandem repeat analysis (MLVA) in eight European countries, 2012
- 2013
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Ingår i: Eurosurveillance. - : European Centre for Disease Prevention and Control. - 1025-496X .- 1560-7917. ; 18:4
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Tidskriftsartikel (refereegranskat)abstract
- Genotyping of important medical or veterinary prokaryotes has become a very important tool during the last decades. Rapid development of fragment-separation and sequencing technologies has made many new genotyping strategies possible. Among these new methods is multilocus variable-number tandem repeat analysis (MLVA). Here we present an update on the use of MLVA in eight European countries (Denmark, France, Germany, Ireland, Italy, the Netherlands, Norway and Sweden). Researchers in Europe have been active in developing and implementing a large array of different assays. MLVA has been used as a typing tool in several contexts, from aiding in resolving outbreaks of foodborne bacteria to typing organisms that may pose a bioterrorist threat, as well as in scientific studies.
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| 10. |
- Nilsson, Lars-Göran, et al.
(författare)
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Cognitive test battery of CASCADE : Tasks and data.
- 2005
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Ingår i: Aging, Neuropsychology and Cognition. - 1382-5585. ; 12:1, s. 32-56
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Tidskriftsartikel (refereegranskat)abstract
- This paper presents the cognitive test battery used in the CASCADE Study (Cardiovascular Determinants of Dementia) for examining the consequences of cerebral white matter lesions and atrophy. The test battery includes nine different tasks assessing memory, executive function, and global cognitive function. Three episodic memory tasks were used in combinations to assess the role of attention and speed on encoding. Estimates of short- and long-term memory capacity were also derived from these three memory tasks. Semantic memory production / frontal lobe functions were assessed by means of a word fluency test. The Letter Digit Substitution test and the Stroop test were used to assess speed of processing and attention. Motor speed was measured with the Purdue Pegboard test, and global cognitive function was assessed by the Mini Mental State Examination. Overall performance data for the whole CASCADE sample and for each of eight study centers are presented for each test. Possible reasons for performance differences among study centers are discussed.
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