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1.	Little, P., et al. (author) Preserved collateral blood flow in the endovascular M2CAO model allows for clinically relevant profiling of injury progression in acute ischemic stroke 2017 In: PLOS ONE. - : Plos. - 1932-6203. ; 12:1 Journal article (peer-reviewed)abstract Interventional treatment regimens have increased the demand for accurate understanding of the progression of injury in acute ischemic stroke. However, conventional animal models severely inhibit collateral blood flow and mimic the malignant infarction profile not suitable for treatment. The aim of this study was to provide a clinically relevant profile of the emergence and course of ischemic injury in cases suitable for acute intervention, and was achieved by employing a M2 occlusion model (M2CAO) that more accurately simulates middle cerebral artery (MCA) occlusion in humans. Twenty-five Sprague-Dawley rats were subjected to Short (90 min), Intermediate (180 min) or Extended (600 min) transient M2CAO and examined longitudinally with interleaved diffusion-, T2- and arterial spin labeling perfusion-weighted magnetic resonance imaging before and after reperfusion. We identified a rapid emergence of cytotoxic edema within tissue regions undergoing infarction, progressing in several distinct phases in the form of subsequent moderation and then reversal at 230 min (p < 0.0001). We identified also the early emergence of vasogenic edema, which increased consistently before and after reperfusion (p < 0.0001). The perfusion of the penumbra correlated more strongly to the perfusion of adjacent tissue regions than did the perfusion of regions undergoing infarction (p = 0.0088). This was interpreted as an effect of preserved collateral blood flow during M2CAO. Accordingly, we observed only limited recruitment of penumbra regions to the infarction core. However, a gradual increase in infarction size was still occurring as late as 10 hours after M2CAO. Our results indicate that patients suffering MCA branch occlusion stand to benefit from interventional therapy for an extended time period after the emergence of ischemic injury.
2.	Bordewijk, J.A, et al. (author) Neutron decay of the isobaric analog state in Bi-208 1994 In: Nucl. Phys. A. ; 574, s. 453- Journal article (peer-reviewed)
3.	Eriksson, Carl, 1981-, et al. (author) Clinical effectiveness of vedolizumab : Interim analysis of the Swedish observational study on vedolizumab assessing effectiveness and healthcare resource utilisation in patients with ulcerative colitis (SVEAH UC) 2018 In: Journal of Crohn's & Colitis. - : Oxford University Press. - 1873-9946 .- 1876-4479. ; 12:Suppl. 1, s. S382-S383 Journal article (other academic/artistic)
4.	Håkansson, A, et al. (author) The C-12(n,gamma0)C-13 cross section in the 8 - 11 MeV region 1990 In: Phys. Rev.C. ; 41, s. 2556-2559 Journal article (peer-reviewed)
5.	Nydén, M., et al. (author) Microemulsions in the didodecyldimethylammonium sulphate(bromide)/hydrocarbon/water system. Microstructure and specific couter ion effects 2001 In: Langmuir. ; :17, s. 6794-6803 Journal article (peer-reviewed)
6.	Söderman, P-O, et al. (author) Neutron decay of deep hole states populated by the Pb-208(3He,alpha)Pb-207 reaction at 102 MeV 1994 In: Nucl. Phys. A. ; 576, s. 215- Journal article (peer-reviewed)
7.	Whiddon, C, et al. (author) Physicochemical properties of a mixed alkylglucoside surfactant/water system: Phase behavior, salt effects and microstructure surrounding a closed-loop liquid/liquid miscibility gap 2002 In: Langmuir. ; 18, s. 4610- Journal article (peer-reviewed)

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Type of publication: journal article (7)

Type of content: peer-reviewed (6); other academic/artistic (1)

Author/Editor: Nilsson, L. (3); Blomgren, J (3); Olsson, N (3); Söderman, P-O (3); Krasznahorkay, A. (2); Hansson, P. (2); show more...; Brandenburg, S (2); van der Woude, A (2); Balanda, A (2); Hofstee, M.A (2); Laurent, H (2); van der Werf, S.Y (2); Perrino, R. (1); Sjöberg, M (1); Damberg, P (1); Nydén, M. (1); Bergemalm, Daniel, 1 ... (1); Halfvarson, Jonas, 1 ... (1); Jonsson, Stefan (1); Gunnarsson, J (1); Holmin, S. (1); Eriksson, Carl, 1981 ... (1); Håkansson, A. (1); Almer, S (1); Grip, O. (1); Hertervig, E. (1); Arnberg, F (1); Little, P (1); Karlen, P (1); Beaumel, D. (1); Lindholm, A. (1); Strid, H (1); Udumyan, Ruzan, 1971 ... (1); Chmielewska, D (1); Ringbom, A. (1); Bordewijk, J.A (1); van 't Hof, G (1); Jänecke, J (1); Sieblink, R (1); Hjortswang, H. (1); Grankvist, R. (1); Wender, S.A (1); Kvist, O (1); Söderman, M (1); Rundquist, Sara, 199 ... (1); Delin, J (1); Lykiardopoulos, V. (1); Söderman, C. (1); Malmgren, C. (1); Öberg, D. (1); show less...

University: Uppsala University (5); Karolinska Institutet (2); Royal Institute of Technology (1); Örebro University (1)

Language: English (7)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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