| 1. |
- Brkic, Sejla, et al.
(författare)
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A family history of Type 1 alcoholism differentiates alcohol consumption in high cortisol responders to stress
- 2015
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Ingår i: Pharmacology Biochemistry and Behavior. - : Elsevier BV. - 0091-3057. ; 130, s. 59-66
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Tidskriftsartikel (refereegranskat)abstract
- Background: The differentiation between high and low cortisol responders to stress is of interest in determining the risk factors which may, along with genetic vulnerability, influence alcohol intake. Study 1: Methods: Thirty-two healthy volunteers, family history positive to alcoholism (FHP, n = 16) and family history negative (FUN, n = 16) attended two laboratory sessions during which alcohol or placebo was offered. Results: There were no differences in consumption of alcohol or placebo between FHP and FHN subjects. Study 2: Methods: Fifty-eight healthy social drinkers, FHP (n = 27) and FUN (n = 31) attended two laboratory sessions. They were administered either alcohol or placebo in both sessions they attended. All subjects underwent either a stress task (the Trier Social Stress Test, TSST) or a stress-free period, at two separate occasions, before being offered beverage. After the salivary cortisol analysis, subjects in each group were divided into high (HCR) or low (LCR) cortisol responders. Results: After stress, subjects who were FHP-HCR consumed more alcohol than FHN-HCR. There were no differences in the placebo intake between FHP and FHN subjects regardless of their cortisol response. Conclusions: This result indicates that stress promotes alcohol consumption only in subjects with a family history of Type 1 alcoholism who show an increase in cortisol response to stress. This behaviour is similar to that previously observed in alcohol dependent individuals after stress and thus could represent an endophenotype posing a risk for future development of alcohol use disorders. (C) 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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| 2. |
- Brkic, Sejla, et al.
(författare)
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High cortisol responders to stress show increased sedation to alcohol compared to low cortisol responders: An alcohol dose-response study
- 2016
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Ingår i: Pharmacology Biochemistry and Behavior. - : Elsevier BV. - 0091-3057. ; 143, s. 65-72
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Tidskriftsartikel (refereegranskat)abstract
- Aims: The present study was designed to examine the relationship between high and low cortisol response to an acute stressful situation and the subjective effects after different doses of alcohol, in healthy social drinkers. Method: Sixty-four subjects (32 men and 32 women) participated in one laboratory session. They performed a modified version of the Trier Social Stress Test (TSST) immediately before consumption of either placebo or alcohol (0.2, 0.4 or 0.8 g/kg). Subjects in each dose group were then divided into high (HCR; n = 32) or low (LCR; n = 32) cortisol responders. Primary dependent measures were self-report questionnaires of mood. Results: The HCR reported increased ratings on Sedation on the Biphasic Alcohol Effects Scale (BAES) with increased dose in comparison with the LCR. This increase in sedation also correlated to the increase in cortisol levels. Conclusion: We conclude that a high cortisol response to stress modulates the subjective response to alcohol, dose-dependently. HCR subjects experience increased sedative effects of alcohol after consumption of higher doses of alcohol following stress compared to LCR subjects.
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| 3. |
- Söderpalm, Bo, 1959, et al.
(författare)
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Stressas vi till missbruk?
- 2005
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Ingår i: Stress. Ed. Ekman R & Arnetz B. - Lund : Liber. - 9789147052585 ; , s. 181-93
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 4. |
- Söderpalm Gordh, Anna, 1971, et al.
(författare)
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Healthy subjects with a family history of alcoholism show increased stimulative subjective effects of alcohol.
- 2011
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Ingår i: Alcoholism, clinical and experimental research. - : Wiley. - 1530-0277 .- 0145-6008. ; 35:8, s. 1426-34
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Tidskriftsartikel (refereegranskat)abstract
- Background: Research has shown that subjects with a family history positive (FHP) of alcoholism are at increased risk for alcoholism and that this group reacts differently to alcohol than family history negative (FHN) subjects. These different levels of sensitivity may make FHP persons more likely to consume alcohol. Here, we tested the hypothesis that subjects FHP for type 1 alcoholism (according to Cloninger) are more sensitive than control subjects to the stimulative, properties of alcohol following a single moderate dose of alcohol. Methods: Fifty-one healthy men and women (22 FHP and 29 FHN) participated in 2 laboratory sessions, in which they consumed a beverage containing ethanol (0.6g/kg in juice) or placebo (juice alone) in a randomized order. Primary dependent measures were self-report questionnaires of mood states. Results: Subjects with family history of type 1 alcoholism showed increased stimulative responses and an elevated positive mood state after ethanol compared to controls. Conclusions: At this moderate dose, ethanol increased stimulative subjective responses in individuals who were "family history positive." This enhanced sensitivity could motivate to exaggerated drinking and thereby increase the risk for developing alcoholism.
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| 5. |
- Söderpalm Gordh, Anna, 1971, et al.
(författare)
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Stress increases consumption of alcohol in humans with a Type 1 Family History of alcoholism in an experimental laboratory setting
- 2011
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Ingår i: Pharmacology Biochemistry and Behavior. - : Elsevier BV. - 0091-3057. ; 99:4, s. 696-703
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: This paper investigates how stress interacts with alcohol consumption in subjects with a family history of alcoholism. One mechanism for increases in alcohol intake may be that stress alters the subjective effects produced by the drug. METHODS: 58 healthy volunteers, divided into two groups of family history positive (FHP) and two groups of family history negative (FHN) participated in two laboratory sessions, in which they performed in one out of two sessions a stress task. Then subjects were allowed to choose up to six additional drinks of ethanol or placebo depending on which session they were randomly assigned to start with. RESULTS: It was found that FHP subjects increased their consumption of alcohol after stress. CONCLUSIONS: It is possible that both stress and alcohol specifically exaggerate the feelings of the reward in the FHP individuals in such way that it may increase the likelihood of consuming more alcohol.
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| 6. |
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| 7. |
- Ericson, Mia, 1970, et al.
(författare)
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Ethanol elevates accumbal dopamine levels via indirect activation of ventral tegmental nicotinic acetylcholine receptors.
- 2003
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Ingår i: European journal of pharmacology. - 0014-2999. ; 467:1-3, s. 85-93
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Tidskriftsartikel (refereegranskat)abstract
- It was previously demonstrated that the central nicotinic acetylcholine receptor antagonist mecamylamine perfused in the ventral tegmental area (VTA) counteracts the elevation of extracellular dopamine levels in the nucleus accumbens after systemic ethanol, as measured by in vivo microdialysis. In the present study we investigated the effect of different concentrations of ethanol perfused locally in the VTA or in the nucleus accumbens on extracellular accumbal dopamine levels. Ethanol (10-1000 mM) perfused in the VTA did not influence dopamine output in the nucleus accumbens. However, ethanol (300 mM) perfused in the nucleus accumbens increased accumbal dopamine levels to approximately the same extent (30%) as observed after systemic ethanol, whereas ethanol (1000 mM) decreased the dopamine output by approximately 50%. Next, the hypothesis that endogenous acetylcholine is required for the increased accumbal dopamine levels after ethanol was challenged. It was shown that in animals pre-treated with vesamicol, a potent inhibitor of vesicular acetylcholine storage, ethanol (300 mM) in the nucleus accumbens failed to elevate extracellular accumbal dopamine levels. Similarly, in animals perfused with mecamylamine in the VTA, but not in the nucleus accumbens, ethanol in the nucleus accumbens (300 mM) failed to increase accumbal dopamine levels. However, whereas dihydro-beta-erythroidine (antagonist for the nicotinic receptor subtype alpha4beta2) perfused in the VTA prevented the increase in accumbal dopamine after systemic nicotine, the antagonist was unable to prevent the dopamine elevating effects of ethanol. Finally, to investigate whether mecamylamine exerts its antagonizing effect of ethanol induced accumbal dopamine levels through an interaction with the NMDA receptor MK-801, the effects of the prototypic NMDA receptor antagonist were examined and compared to those of mecamylamine. After perfusion in the VTA, MK-801 enhanced accumbal dopamine levels by itself but did not antagonize the enhancing effect of ethanol. The present set of experiments indicate that the mesolimbic dopamine activating effects of ethanol may be due to an indirect rather than direct activation of ventral tegmental nicotinic acetylcholine receptors of a subtype composition different from the alpha4beta2. Furthermore, it is argued that the primary site of action of ethanol in its accumbal dopamine elevating effect may be located to the nucleus accumbens or nearby regions.
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| 8. |
- Ericson, Mia, 1970, et al.
(författare)
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Taurine elevates dopamine levels in the rat nucleus accumbens; antagonism by strychnine.
- 2006
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Ingår i: The European journal of neuroscience. - : Wiley. - 0953-816X .- 1460-9568. ; 23:12, s. 3225-9
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Tidskriftsartikel (refereegranskat)abstract
- The mesolimbic dopamine (DA) system, projecting from the ventral tegmental area (VTA) to the nucleus accumbens (nAcc), is involved in reward-related behaviours and addictive processes, such as alcoholism and drug addiction. It was recently suggested that strychnine-sensitive glycine receptors (GlyR) in the nAcc regulate both basal and ethanol-induced mesolimbic DA activity via a neuronal loop involving endogenous activation of nicotinic acetylcholine receptors (nAChR) in the VTA. However, as the nAcc appears to contain few glycine-immunoreactive cell bodies or fibres, the question as to what may be the endogenous ligand for GlyRs in this brain region remains open. Here we have investigated whether the amino acid taurine could serve this purpose using in vivo microdialysis in awake, freely moving male Wistar rats. Local perfusion of taurine (1, 10 or 100 mm in the perfusate) increased DA levels in the nAcc. The taurine (10 mm)-induced DA increase was, similarly to that previously observed after ethanol, completely blocked by (i) perfusion of the competitive GlyR antagonist strychnine in the nAcc, (ii) perfusion of the nAChR antagonist mecamylamine (100 microm) in the VTA, and (iii) systemic administration of the acetylcholine-depleting drug vesamicol (0.4 mg/kg, i.p). The present results suggest that taurine may be an endogenous ligand for GlyRs in the nAcc and that the taurine-induced elevation of DA levels in this area, similarly to that observed after local ethanol, is mediated via a neuronal loop involving endogenous activation of nAChRs in the VTA.
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| 9. |
- Hagsand, Angelica, 1985, et al.
(författare)
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Alcohol, crime and memory. Intoxicated eyewitnesses delayed recall of a kidnapping.
- 2012
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Ingår i: Svenska föreningen för Alkohol- och Drogforskning, konferens 8-9 November, Norrköping.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Alcohol is involved in 50-70% of violent crimes in Sweden. Eyewitness memory is a valuable source in investigations and it is common that the police interview alcohol intoxicated eyewitnesses. There are few studies on how alcohol affects witness memory. This study investigated how different doses of alcohol affected eyewitness recall one week after witnessing a crime and potential sex differences. The participants (N = 126) were healthy adults and were randomly assigned to either a control group, 0.0 g/kg ethanol (N = 42), a lower alcohol dose group, 0.4 g/kg ethanol (N = 40), or a higher alcohol dose group, 0.7 g/kg ethanol (N = 44). After 15 minutes consumption in a laboratory, participants witnessed a film showing a kidnapping of a woman by two men. The witnesses were interviewed about the crime one week later in a sober state. Witnesses in the higher alcohol dose group recalled fewer details compared to witnesses in the lower alcohol dose group. The amount of alcohol consumed did not have an impact on accuracy. Women and men reached the same blood alcohol concentration and no sex differences were found in recall. Interestingly, although the witnesses in the high alcohol dose group reported less information, their testimony was as correct as the testimony given by witnesses in the control group and the lower alcohol dose group. Despite the interesting results, more studies are needed before recommendations to the legal system can be made.
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| 10. |
- Hagsand, Angelica, 1985, et al.
(författare)
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Alcohol intoxicated eyewitnesses´ delayed recall of a kidnapping.
- 2013
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Ingår i: Poster presented at the European Association of Psychology and Law, 5th of September 2013, Coventry, UK..
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This study investigated how different doses of alcohol affected eyewitness recall. Participants (N = 126) were randomly assigned to three groups with different blood alcohol concentration (BAC), either a control group (mean BAC 0.00%, N = 42), a lower alcohol dose group (mean BAC 0.04%, N = 40), or a higher alcohol dose group (mean BAC 0.06%, N = 44). After consumption in a laboratory, participants witnessed a film of a mock crime where a woman was kidnapped by two men. One week after, the witnesses were interviewed in a sober state, by interviewers who were blind to which beverage the witnesses had consumed the week before. The main results showed that witnesses with the higher intoxication level recalled fewer details compared to witnesses with the lower intoxication level. The amount of alcohol consumed did not have an impact on the accuracy rate. No sex differences were found. We conclude that more studies are needed before recommendations can be made to an applied setting, but this study showed that alcohol may have a negative impact on eyewitness recall.
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