| 1. |
- Fagerholm, Per, et al.
(författare)
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A biosynthetic alternative to human donor tissue for inducing corneal regeneration : 24-month follow-up of a phase 1 clinical study
- 2010
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Ingår i: Science translational medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6234 .- 1946-6242. ; 2:46, s. 46-61
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Tidskriftsartikel (refereegranskat)abstract
- Corneas from human donors are used to replace damaged tissue and treat corneal blindness, but there is a severe worldwide shortage of donor corneas. We conducted a phase 1 clinical study in which biosynthetic mimics of corneal extracellular matrix were implanted to replace the pathologic anterior cornea of 10 patients who had significant vision loss, with the aim of facilitating endogenous tissue regeneration without the use of human donor tissue. The biosynthetic implants remained stably integrated and avascular for 24 months after surgery, without the need for long-term use of the steroid immunosuppression that is required for traditional allotransplantation. Corneal reepithelialization occurred in all patients, although a delay in epithelial closure as a result of the overlying retaining sutures led to early, localized implant thinning and fibrosis in some patients. The tear film was restored, and stromal cells were recruited into the implant in all patients. Nerve regeneration was also observed and touch sensitivity was restored, both to an equal or to a greater degree than is seen with human donor tissue. Vision at 24 months improved from preoperative values in six patients. With further optimization, biosynthetic corneal implants could offer a safe and effective alternative to the implantation of human tissue to help address the current donor cornea shortage.
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| 2. |
- Hammer, Monica, et al.
(författare)
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Enhancing transdisciplinary dialogue in curricula development
- 2001
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Ingår i: Ecological Economics. - : Elsevier. - 0921-8009 .- 1873-6106. ; 38, s. 1-5
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- A crucial step towards realizing transdisciplinary understanding is to address transdisciplinary issues in university curricula, and to train students in critically analyzing and understanding disciplinary metaphors. We present an experimental exercise at Stockholm University with the aim of finding a constructive way to introduce transdisciplinary elements in disciplinary courses and thus increase student awareness of disciplinary metaphors. The exercise required a minimum of formal university decision procedures and thus circumvented the institutional barriers that tend to obstruct the establishment of full transdisciplinary programs.
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| 5. |
- Olsson, Ann
(författare)
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Suberin based polyesters
- 2009
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- In the wish to replace oil-based chemicals and materials with such based on biodegradable and renewable resources, this work has been performed. In a biorefinary concept, waste birch bark from paper pulp mills and timber production has been evaluated as a potential source for polyesters. In the present thesis investigations are made on synthesis of epoxy-functionalized polyesters from the birch outer bark aliphatic suberin ω-hydroxy fatty acid, cis-9,10-epoxy-18-hydroxyoctadecanoic acid. Studies of accessibility and reactivity of cellulose have been performed as a first step to enable covalent attachment or grafting of the epoxy-functionalized polyesters to cellulose. Candida antarctica lipase B (Novozym 435) is reported to be an efficient catalyst for condensation polymerization of cis-9,10-epoxy-18-hydroxyoctadecanoic acid to form poly(9,10-epoxy-18-hydroxyoctadecanoic acid) with high molecular weight (Mw). Performed in toluene in the presence of molecular sieves a Mw of 20000 (reaction time 68 h, Mw/Mn 2.2) was obtained. Performed in bulk without any drying agent a Mw of 15000 was obtained at a much shorter reaction time (reaction time 3h, Mw/Mn 2.2). Further the same lipase has been used for succesful co-polymerizations of cis-9,10-epoxy-18-hydroxyoctadecanoic acid with lactones. By combining condensation and ring-opening polymerization, epoxy-functionalized linear polyesters and cyclic oligomers have been synthesized. For example, co-polymerization of cis-9,10-epoxy-18-hydroxy-octadecanoic acid and ε-caprolactone performed in toluene in the presence of molecular sieves gave mainly cyclic oligomers, especially at shorter reaction times. Co-polymerization performed in bulk gave linear polyesters with a Mw of 35000 (reaction time 24 h, Mw/Mn 6), irrespective molecular sieves were added or not. The epoxy-functionalized polyesters could be used for surface modification of pulp fibres and cellulose fibrils, which further can be used for production of new valuable composite materials with improved features. Knowledge of how different processing conditions affect the structure of cellulose is an important tool in the work to achieve successful grafting of produced polyesters to cellulose fibres/fibrils. CP/MAS 13C-NMR spectroscopy has been used to study structural changes caused by the dissolving pulp process. An irreversible increase in average fibril aggregate width from raw pulp to final pulp during the process is shown. This increase in aggregate width could negatively influence the reactivity of the cellulose.
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| 6. |
- Söderqvist, Marit, et al.
(författare)
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Knowledge Transfer Partnership (KTP)
- 2023
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Konferensbidrag (populärvet., debatt m.m.)abstract
- Lärosäten förväntas påverka och påverkas av omgivande samhälle, men det finns utmaningar att finna hållbara vägar för kommunikation i båda riktningar. Ett verktyg för samverkan är Knowledge Transfer Partnership (KTP) som gör det möjligt att såväl sprida lärosätets kunskap, som att lära av de kunskaper och erfarenheter som genereras i övriga samhället.Knowledge Transfer Partnership (KTP) kommer från Storbritannien där man jobbat med modellen nationellt i över 40 år. Högskolan Dalarna började som första lärosäte i Sverige arbeta med KTP, redan år 2012. Sedan dess har lärosätet jobbat med ett 100-tal KTP-projekt ute i näringslivet och under de senaste åren även fått möjlighet att lära upp personer vid andra lärosäten genom det nationella projektet ”KTP Energi Sverige”.Under detta pass får du lära dig mer om samverkansverktyget KTP och konkreta exempel på hur akademi och näringsliv kan mötas på ett för alla framgångsrikt sätt.
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