| 1. |
|
|
| 2. |
|
|
| 3. |
- Choularton, T. W., et al.
(författare)
-
The Great Dun Fell Cloud Experiment 1993 : An overview
- 1997
-
Ingår i: Atmospheric Environment. - 1352-2310. ; 31:16, s. 2393-2405
-
Tidskriftsartikel (refereegranskat)abstract
- The 1993 Ground-based Cloud Experiment on Great Dun Fell used a wide range of measurements of trace gases, aerosol particles and cloud droplets at five sites to study their sources and sinks especially those in cloud. These measurements have been interpreted using a variety of models. The conclusions add to our knowledge of air pollution, acidification of the atmosphere and the ground, eutrophication and climate change. The experiment is designed to use the hill cap cloud as a flow-through reactor, and was conducted in varying levels of pollution typical of much of the rural temperate continental northern hemisphere in spring-time.
|
|
| 4. |
|
|
| 5. |
- Fuzzi, S., et al.
(författare)
-
The Po Valley Fog Experiment 1989
- 1992
-
Ingår i: Tellus. Series B: Chemical and Physical Meteorology. - : Stockholm University Press. - 0280-6509. ; 44:5, s. 448-468
-
Tidskriftsartikel (refereegranskat)abstract
- An outline is presented here of the Po Valley Fog Experiment 1989, carried out within the EUROTRAC‐GCE project. This experiment is a joint effort by several European research groups from 5 countries. The physical and chemical behaviour of the fog multiphase system was studied experimentally following the temporal evolution of the relevant chemical species in the different phases (gas, droplet, interstitial aerosol) and the evolution of micrometeorological and microphysical conditions, from the pre‐fog situation through the whole fog evolution, to the post‐fog period. Some general results, useful for describing the general features of the fog system, are presented here, while specific scientific questions on the different processes taking place within the system itself will be addressed in other companion papers of this same issue.
|
|
| 6. |
- Cederfelt, S. I., et al.
(författare)
-
Field validation of the droplet aerosol analyser
- 1997
-
Ingår i: Atmospheric Environment. - 1352-2310. ; 31:16, s. 2657-2670
-
Tidskriftsartikel (refereegranskat)abstract
- A new instrument for the study of cloud droplets and its relation to aerosol particles, the droplet aerosol analyser (DAA), was for the first time used in a field campaign. The DAA has the unique feature of measuring the ambient size of cloud droplets or cloud interstitial aerosol particles together with the size of its dry residue. This is obtained with a two-parameter data acquisition technique which results in a three-dimensional data set (ambient size, dry residue size, number concentration). The principle and design of the DAA is briefly described. The DAA was intercompared with differential mobility particle sizers, particulate volume monitors and a forward scattering spectrometer probe with respect to interstitial and cloud droplet dry residue size distribution as well as particle-size-dependent scavenging due to cloud droplet nucleation and for cloud droplet number concentration and size distribution and cloud liquid water concentration. Overall, the DAA showed good agreement with respect to all these six aerosol/cloud properties.
|
|
| 7. |
|
|
| 8. |
- Martinsson, B. G., et al.
(författare)
-
Experimental determination of the connection between cloud droplet size and its dry residue size
- 1997
-
Ingår i: Atmospheric Environment. - 1352-2310. ; 31:16, s. 2477-2490
-
Tidskriftsartikel (refereegranskat)abstract
- The droplet activation process and droplet growth was studied during early stages of the formation of orographically-induced clouds. The experimental results were compared with the results obtained with a closed parcel, adiabatic cloud model. Good agreement was in most cases found between model and measurements with respect to cloud droplet number concentration, cloud droplet solute concentration and particle sizes scavenged due to cloud droplet nucleation. The experimental results were mainly obtained with a new instrument, the droplet aerosol analyser (DAA), which allows the determination of ambient sizes of cloud droplets and interstitial aerosol particles directly connected with the size of its dry residue in a two-parameter data acquisition. The resulting three-dimensional data set (ambient size, dry size, number concentration) was utilised to determine several cloud/aerosol properties, whereof some unique.
|
|
| 9. |
- Vereb, D., et al.
(författare)
-
Age-related differences in the functional topography of the locus coeruleus and their implications for cognitive and affective functions
- 2023
-
Ingår i: eLife. - 2050-084X. ; 12
-
Tidskriftsartikel (refereegranskat)abstract
- The locus coeruleus (LC) is an important noradrenergic nucleus that has recently attracted a lot of attention because of its emerging role in cognitive and psychiatric disorders. Although previous histological studies have shown that the LC has heterogeneous connections and cellular features, no studies have yet assessed its functional topography in vivo, how this heterogeneity changes over aging, and whether it is associated with cognition and mood. Here, we employ a gradient-based approach to characterize the functional heterogeneity in the organization of the LC over aging using 3T resting-state fMRI in a population-based cohort aged from 18 to 88 years of age (Cambridge Centre for Ageing and Neuroscience cohort, n=618). We show that the LC exhibits a rostro-caudal functional gradient along its longitudinal axis, which was replicated in an independent dataset (Human Connectome Project [HCP] 7T dataset, n=184). Although the main rostro-caudal direction of this gradient was consistent across age groups, its spatial features varied with increasing age, emotional memory, and emotion regulation. More specifically, a loss of rostral-like connectivity, more clustered functional topography, and greater asymmetry between right and left LC gradients was associated with higher age and worse behavioral performance. Furthermore, participants with higher-than-normal Hospital Anxiety and Depression Scale (HADS) ratings exhibited alterations in the gradient as well, which manifested in greater asymmetry. These results provide an in vivo account of how the functional topography of the LC changes over aging, and imply that spatial features of this organization are relevant markers of LC-related behavioral measures and psychopathology.
|
|
| 10. |
- Bergström, Sofia, et al.
(författare)
-
Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease
- 2021
-
Ingår i: Annals of Clinical and Translational Neurology. - : Wiley. - 2328-9503. ; 8:7, s. 1456-1470
-
Tidskriftsartikel (refereegranskat)abstract
- Objective: Decreased amyloid beta (A beta) 42 together with increased tau and phospho-tau in cerebrospinal fluid (CSF) is indicative of Alzheimer's disease (AD). However, the molecular pathophysiology underlying the slowly progressive cognitive decline observed in AD is not fully understood and it is not known what other CSF biomarkers may be altered in early disease stages. Methods: We utilized an antibody-based suspension bead array to analyze levels of 216 proteins in CSF from AD patients, patients with mild cognitive impairment (MCI), and controls from two independent cohorts collected within the AETIONOMY consortium. Two additional cohorts from Sweden were used for biological verification. Results: Six proteins, amphiphysin (AMPH), aquaporin 4 (AQP4), cAMP-regulated phosphoprotein 21 (ARPP21), growth-associated protein 43 (GAP43), neurofilament medium polypeptide (NEFM), and synuclein beta (SNCB) were found at increased levels in CSF from AD patients compared with controls. Next, we used CSF levels of A beta 42 and tau for the stratification of the MCI patients and observed increased levels of AMPH, AQP4, ARPP21, GAP43, and SNCB in the MCI subgroups with abnormal tau levels compared with controls. Further characterization revealed strong to moderate correlations between these five proteins and tau concentrations. Interpretation: In conclusion, we report six extensively replicated candidate biomarkers with the potential to reflect disease development. Continued evaluation of these proteins will determine to what extent they can aid in the discrimination of MCI patients with and without an underlying AD etiology, and if they have the potential to contribute to a better understanding of the AD continuum.
|
|
