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Sökning: WFRF:(SZPIRER C)

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1.
  • Andersson, A, et al. (författare)
  • Genes for C4b-binding protein alpha- and beta-chains (C4BPA and C4BPB) are located on chromosome 1, band 1q32, in humans and on chromosome 13 in rats
  • 1990
  • Ingår i: Somatic Cell and Molecular Genetics. - 0740-7750. ; 16:5, s. 493-500
  • Tidskriftsartikel (refereegranskat)abstract
    • C4b-binding protein is involved in the regulation of the complement system. It is a multimeric protein composed of seven identical alpha-chains and a single copy of a unique beta-chain. The latter was identified only recently and its structure determined by cDNA cloning. Both subunits in C4b-binding protein belong to the same superfamily of proteins composed predominantly of tandemly arranged short consensus repeats (SCR) approximately 60 amino acid residues in length. The gene for the human alpha-chain is known to be located in a gene cluster on chromosome 1, band 1q32, which is called the regulators of complement activation (RCA) gene cluster. We have used cDNA probes for both alpha- and beta-chains of human C4b-binding protein to localize their genes with an in situ hybridization technique. We find the genes for both chains to be located on chromosome 1, band 1q32, in the human. This suggests that the beta-chain gene is also a member of the RCA gene cluster and that the alpha- and beta-chain genes are located close to each other. The cDNA probes for the alpha- and beta-chains also were used to screen mouse-rat somatic cell hybrids using Southern blotting to localize their genes in the rat. Both the alpha- and beta-chain genes were shown to be located on chromosome 13 in the rat. These are the second and third genes to be located on rat chromosome 13, and the results suggest that the genes for the alpha- and beta-chains together with the gene for coagulation factor V represent a conserved chromosomal region in rat and man.
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2.
  • Dahlbäck, Björn, et al. (författare)
  • Assignment of gene for coagulation factor V to chromosome 1 in man and to chromosome 13 in rat
  • 1988
  • Ingår i: Somatic Cell and Molecular Genetics. - 0740-7750. ; 14:5, s. 14-509
  • Tidskriftsartikel (refereegranskat)abstract
    • Two different factor V cDNA fragments were used as hydridization probes in the chromosomal assignment of the human and rat factor V genes. A 1.6-kb EcoRI fragment was used as a hybridization probe to analyze a panel of human-rodent somatic cell hybrids. Cosegregation of factor V specific DNA restriction fragments with human chromosome 1 was observed. In addition, a panel of rat-mouse somatic cell hybrids was analyzed with another human factor V cDNA probe to localize the gene for rat coagulation factor V. In the rat, the gene for coagulation factor V was found to be located in chromosome 13. This is the first gene in the rat to be localized to chromosome 13.
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  • Klinga-Levan, K, et al. (författare)
  • The rat gene map 1995
  • 1995
  • Rapport (övrigt vetenskapligt/konstnärligt)
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6.
  • Klinga-Levan, K, et al. (författare)
  • The rat gene map 1996
  • 1996
  • Rapport (övrigt vetenskapligt/konstnärligt)
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7.
  • Levan, G, et al. (författare)
  • The rat gene map
  • 1998
  • Ingår i: ILAR journal. - : Institute for Laboratory Animal Research. - 1084-2020 .- 1930-6180. ; 39, s. 132-137
  • Tidskriftsartikel (refereegranskat)
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  • Resultat 1-10 av 18

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