| 1. |
- Gylling, Mikhail, et al.
(författare)
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The hypoparathyroidism of autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy protective effect of male sex
- 2003
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - 0021-972X .- 1945-7197. ; 88:10, s. 4602-4608
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy, hypoparathyroidism (HP) is the most common endocrine component. It occurs in most (but not all) patients. Determinants of its occurrence are unknown, and there is no proof for its autoimmune nature. Recently, the Ca(2+)-sensing receptor (CaSR) was reported to be an autoantigen in HP. With our group of 90 patients, we aimed at identifying the determinants and pathomechanism of HP. For the determinants, we evaluated gender and the HLA class II. For the pathomechanism, we searched for parathyroid autoantibodies, including antibodies against CaSR and PTH. Also, we studied whether AIRE is expressed in the human parathyroid, because its absence could be a pathogenetic factor. We found a clear gender linkage with lower and later incidence in males. Of the 14 patients who had escaped HP, 13 were males. This was associated with adrenal failure, which was the first or only endocrinopathy in 47% of males vs. 7% of females. In contrast, we found no linkage to the HLA class II. By immunofluorescence, 19% of the patients had antibodies to parathyroid epithelia. By immunoblotting, these recognized several parathyroid proteins. No antibodies were observed against the CaSR or PTH. By RT-PCR, AIRE mRNA was not found in the parathyroid.
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| 2. |
- Kyösti, Petter, et al.
(författare)
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Process-SME Project : Exceeded Expectations
- 2019
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Rapport (populärvet., debatt m.m.)abstract
- This publication ‘Process-SME Project – Exceeded Expectations’ introduces a Nordic project Process-SME, which main objective is to improve the competitiveness of SMEs whose customers are found within the process, mining, energy, oil, and gas industries. The project supports these SMEs by identifying their needs and potential opportunities, developing new business models, building European partnerships and applying for EU-level funding for project proposals on SMEs’ business behalf. Furthermore, the Process-SME project aims to develop SMEs’ products, services and other offerings.
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| 3. |
- Lindström, John, et al.
(författare)
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European roadmap for industrial process automation
- 2018
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This is an updated version of the ProcessIT. EU roadmap for industrial process automation, which was initially released in 2013 to provide guidance and input for process industry companies, providers of process industrial IT- and automation solutions, researchers as well as policy makers and bodies/initiatives that craft calls for RDI-projects. The main objective is for European process industry to stay competitive, profitable and sustainable. Thus, to support European process industry in its industrial process automation endeavours, the ProcessIT. EU roadmap outlines three top-level needs: sustainable production, competence management and trust, security, safety and privacy. These three top-level needs intersect the following ten R&D areas:• Productivity, efficiency, scalability and flexibility• Sustainability through circular economy - circular economy through industrial internet• Distributed production/modular factories and services• Artificial Intelligence and Big Data• Autonomous plants and remote operations• Platform economy• Cybersecurity• Safety - human, machine and environment• Competences and quality of work• Human-Machine Interfaces and Machine- to-Machine communications,which in turn are used as building blocks in the nine gamechangers . The gamechangers aim to influence the process industries’ competitiveness, profitability and sustainability . The gamechangers are listed below:• Modular factory for distributed and automated production• Live virtual twins of raw-materials, process and products• Increased information transparency between field and ERP• Real-time data analytics• Dynamic control and optimisation of output tolerances• Process industry as an integrated and agile part of the energy system• Management of critical knowledge• Semi-autonomous automation engineering• Integrated operational and cybersecurity managementFinally, the ProcessIT. EU roadmap provides an insight into what may need to be considered on strategic and tactical levels, in terms of: objec-tives, R&D areas, game changers and business modelling, to keep and develop the competitive edge and initiative.
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