| 1. |
- Autti, Taina, et al.
(författare)
-
Bone marrow transplantation in aspartylglucosaminuria : histopathological and MRI study
- 1999
-
Ingår i: Neuropediatrics. - : Georg Thieme Verlag KG. - 0174-304X .- 1439-1899. ; 30:6, s. 283-8
-
Tidskriftsartikel (refereegranskat)abstract
- This study comprised two patients with aspartylglucosaminuria (AGU), who were followed up for 4 and 7 years. The patients underwent allogeneic bone marrow transplantation (BMT) at the ages of 2 and 2.6 years. Both patients had abnormal speech development and gross motor clumsiness. At the time of the BMT, they were mentally retarded. We report on follow-up data of these patients obtained by MRI, in addition to the histopathological, biochemical and clinical investigations. MR images of six non-transplanted patients and seven healthy children served as controls. In the non-transplanted patients, MRI revealed evident delay of myelination in contrast to the two transplanted patients showing fair or evident grey- vs. white matter differentiation on T2-weighted images. The aspartylglucosaminidase (AGA) activity in blood leukocytes reached a heterozygous level. Urinary excretion of aspartylglucosamine and glycoasparagines slowly decreased but remained about a third of the pre-BMT level 5 years after BMT. Storage lysosomes in electron microscopic investigations were not decreased 6 months after BMT, but after 1.5-2 years, rectal mucosa samples showed a decrease in the storage vacuoles of different cells. Three years after BMT, no cells with storage vacuoles were present. Allogeneic BMT slowly normalises the pathological, biochemical and MRI findings in patients with AGU.
|
|
| 2. |
- Carvalho Bittencourt, André, 1984-, et al.
(författare)
-
A data-driven approach to diagnostics of repetitive processes in the distribution domain : Applications to gearbox diagnosticsin industrial robots and rotating machines
- 2014
-
Ingår i: Mechatronics (Oxford). - : Elsevier. - 0957-4158 .- 1873-4006. ; 24:8, s. 1032-1041
-
Tidskriftsartikel (refereegranskat)abstract
- This paper presents a data-driven approach to diagnostics of systems that operate in a repetitive manner. Considering that data batches collected from a repetitive operation will be similar unless in the presence of an abnormality, a condition change is inferred by comparing the monitored data against an available nominal batch. The method proposed considers the comparison of data in the distribution domain, which reveals information of the data amplitude. This is achieved with the use of kernel density estimates and the Kullback–Leibler distance. To decrease sensitivity to disturbances while increasing sensitivity to faults, the use of a weighting vector is suggested which is chosen based on a labeled dataset. The framework is simple to implement and can be used without process interruption, in a batch manner. The approach is demonstrated with successful experimental and simulation applications to wear diagnostics in an industrial robot gearbox and for diagnostics of gear faults in a rotating machine.
|
|
| 3. |
- Carvalho Bittencourt, André, 1984-, et al.
(författare)
-
A Data-Driven Method for Monitoring of Repetitive Systems: Applications to Robust Wear Monitoring of a Robot Joint
- 2013
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This paper presents a method for monitoring of systems that operate in a repetitive manner. Considering that data batches collected from a repetitive operation will be similar unless in the presence of an abnormality, a condition change is inferred by comparing the monitored data against a nominal batch. The method proposed considers the comparison of data in the distribution domain, which reveals information of the data amplitude. This is achieved with the use of kernel density estimates and the Kullback-Leibler distance. To decrease sensitivity to unknown disturbances while increasing sensitivity to faults, the use of a weighting vector is suggested which is chosen based on a labeled dataset. The framework is simple to implement and can be used without process interruption, in a batch manner. The method was developed with interests in industrial robotics where a repetitive behavior is commonly found. The problem of wear monitoring in a robot joint is studied based on data collected from a test-cycle. Real data from accelerated wear tests and simulations are considered. Promising results are achieved where the method output shows a clear response to the wear increases.
|
|
| 4. |
- Carvalho Bittencourt, André, et al.
(författare)
-
A Data-Driven Method for Monitoring Systems that Operate Repetitively : Applications to Robust Wear Monitoring inan Industrial Robot Joint
- 2011
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- This paper presents a method for condition monitoring of systems that operate in a repetitive manner. A data driven method is proposed that considers changes in the distribution of data samples obtained from multiple executions of one or several tasks. This is made possible with the use of kernel density estimators and the Kullback-Leibler distance measure between distributions. To increase robustness to unknown disturbances and sensitivity to faults, the use of a weighting function is suggested which can considerably improve detection performance. The method is very simple to implement, it does not require knowledge about the monitored system and can be used without process interruption, in a batch manner. The method is illustrated with applications to robust wear monitoring in a robot joint. Interesting properties of the application are presented through a real case study and simulations. The achieved results show that robust wear monitoring in industrial robot joints is made possible with the proposed method.
|
|
| 5. |
|
|
| 6. |
- Evans, Alistair R., et al.
(författare)
-
The maximum rate of mammal evolution
- 2012
-
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 109:11, s. 4187-4190
-
Tidskriftsartikel (refereegranskat)abstract
- How fast can a mammal evolve from the size of a mouse to the size of an elephant? Achieving such a large transformation calls for major biological reorganization. Thus, the speed at which this occurs has important implications for extensive faunal changes, including adaptive radiations and recovery from mass extinctions. To quantify the pace of large-scale evolution we developed a metric, clade maximum rate, which represents the maximum evolutionary rate of a trait within a clade. We applied this metric to body mass evolution in mammals over the last 70 million years, during which multiple large evolutionary transitions occurred in oceans and on continents and islands. Our computations suggest that it took a minimum of 1.6, 5.1, and 10 million generations for terrestrial mammal mass to increase 100-, and 1,000-, and 5,000-fold, respectively. Values for whales were down to half the length (i.e., 1.1, 3, and 5 million generations), perhaps due to the reduced mechanical constraints of living in an aquatic environment. When differences in generation time are considered, we find an exponential increase in maximum mammal body mass during the 35 million years following the Cretaceous-Paleogene (K-Pg) extinction event. Our results also indicate a basic asymmetry in macroevolution: very large decreases (such as extreme insular dwarfism) can happen at more than 10 times the rate of increases. Our findings allow more rigorous comparisons of microevolutionary and macroevolutionary patterns and processes.
|
|
| 7. |
- Fortelius, Mikael, et al.
(författare)
-
The Origin and Early History of NOW as It Happened
- 2023
-
Ingår i: Evolution of Cenozoic Land Mammal Faunas and Ecosystems: 25 years of the NOW database of fossil mammals.. - : Springer. ; , s. 7-32
-
Bokkapitel (refereegranskat)abstract
- The NOW database of fossil mammals came to be through a confluence of several initiatives spanning multiple decades. The first public version of NOW database was released in 1996 and the first Advisory Board was established the year after. Originally, NOW stood for Neogene of the Old World but with the gradual expansion of the database the acronym was eventually reassigned to stand for New and Old Worlds. The structure of what would become NOW was originally cloned from the ETE database of the Smithsonian Institution and the first NOW version accessible over the internet was a node of the ETE database. The first standalone, online version of NOW was launched in 2005 and the first formal steering group was established in 2009. During its existence, NOW has been funded, directly or indirectly, by several organizations but fundamentally it has always been an unfunded community effort, dependent on voluntary work by the participants.
|
|
| 8. |
- Saarinen, Kari, et al.
(författare)
-
Criticality Analysis Based Maintenance
- 2013
-
Ingår i: Journal of Asset Management. - : Engineering Information Transfer. - 1470-8272 .- 1479-179X. ; 26:6, s. 16-19
-
Tidskriftsartikel (refereegranskat)abstract
- Changing from a reactive to a preventive maintenance strategy can yield substantial cost savings in many sectors of industry. However, in the process industries, an installation may have many thousands of maintenance-worthy elements, rendering a solely preventive maintenance strategy impractical or even impossible. How then to determine the optimal maintenance strategy mix for such situations?
|
|
| 9. |
- Samuelsson, Andreas, et al.
(författare)
-
Simulation based Evaluation of Fault Detection Algorithms : Applications to Wear Diagnosis in Manipulators
- 2014
-
Ingår i: Proceedings of the 19th IFAC World Congress.
-
Konferensbidrag (refereegranskat)abstract
- Fault detection algorithms (FDAs) process data to generate a test quantity. Test quantities are used to determine presence of a fault in a monitored system, despite disturbances. Because only limited knowledge of the system can be embedded in an FDA, it is important to evaluate it in scenarios relevant in practice. In this paper, simulation based approaches are proposed in an attempt to determine: i) which disturbances affect the output of an FDA the most; ii) how to compare the performance of dierent FDAs; and iii) which combinations of fault change size and disturbances variations are allowed to achieve satisfactory performance. The ideas presented are inspired by the literature of design of experiments, surrogate models, sensitivity analysis and change detection. The approaches are illustrated for the problem of wear diagnosis in manipulators where three FDAs are considered. The application study reveals that disturbances caused by variations in temperature and payload mass error affect the FDAs the most. It is also shown how the size of these disturbances delimit the capacity of an FDA to relate to wear changes. Further comparison of the FDAs reveal which performs "best" in average.
|
|
| 10. |
- Smith, Felisa A, et al.
(författare)
-
The evolution of maximum body size of terrestrial mammals
- 2010
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 330:6008, s. 1216-1219
-
Tidskriftsartikel (refereegranskat)abstract
- The extinction of dinosaurs at the Cretaceous/Paleogene (K/Pg) boundary was the seminal event that opened the door for the subsequent diversification of terrestrial mammals. Our compilation of maximum body size at the ordinal level by sub-epoch shows a near-exponential increase after the K/Pg. On each continent, the maximum size of mammals leveled off after 40 million years ago and thereafter remained approximately constant. There was remarkable congruence in the rate, trajectory, and upper limit across continents, orders, and trophic guilds, despite differences in geological and climatic history, turnover of lineages, and ecological variation. Our analysis suggests that although the primary driver for the evolution of giant mammals was diversification to fill ecological niches, environmental temperature and land area may have ultimately constrained the maximum size achieved.
|
|
