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Sökning: WFRF:(Sachikonye M)

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1.
  • Underwood, J, et al. (författare)
  • Validation of a Novel Multivariate Method of Defining HIV-Associated Cognitive Impairment
  • 2019
  • Ingår i: Open forum infectious diseases. - : Oxford University Press (OUP). - 2328-8957. ; 6:6, s. ofz198-
  • Tidskriftsartikel (refereegranskat)abstract
    • BackgroundThe optimum method of defining cognitive impairment in virally suppressed people living with HIV is unknown. We evaluated the relationships between cognitive impairment, including using a novel multivariate method (NMM), patient– reported outcome measures (PROMs), and neuroimaging markers of brain structure across 3 cohorts.MethodsDifferences in the prevalence of cognitive impairment, PROMs, and neuroimaging data from the COBRA, CHARTER, and POPPY cohorts (total n = 908) were determined between HIV-positive participants with and without cognitive impairment defined using the HIV-associated neurocognitive disorders (HAND), global deficit score (GDS), and NMM criteria.ResultsThe prevalence of cognitive impairment varied by up to 27% between methods used to define impairment (eg, 48% for HAND vs 21% for NMM in the CHARTER study). Associations between objective cognitive impairment and subjective cognitive complaints generally were weak. Physical and mental health summary scores (SF-36) were lowest for NMM-defined impairment (P < .05).There were no differences in brain volumes or cortical thickness between participants with and without cognitive impairment defined using the HAND and GDS measures. In contrast, those identified with cognitive impairment by the NMM had reduced mean cortical thickness in both hemispheres (P < .05), as well as smaller brain volumes (P < .01). The associations with measures of white matter microstructure and brain-predicted age generally were weaker.ConclusionDifferent methods of defining cognitive impairment identify different people with varying symptomatology and measures of brain injury. Overall, NMM-defined impairment was associated with most neuroimaging abnormalities and poorer self-reported health status. This may be due to the statistical advantage of using a multivariate approach.
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2.
  • Beckman, Björn, 1938-, et al. (författare)
  • Introduction
  • 2010
  • Ingår i: Trade Unions and party Politics. - Cape Town : HSCR PRESS. - 9780796923066 - 079692306X
  • Bokkapitel (refereegranskat)
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4.
  • Sachikonye, Lloyd M. (författare)
  • Restructuring or de-industrializing? : Zimbabwe's textile and metal industries under structural adjustment
  • 1999
  • Rapport (övrigt vetenskapligt/konstnärligt)abstract
    • This report is a contribution to the growing literature on the impact of structural adjustment on the manufacturing sector in Africa and it has the distinction of being one of the first longitudinal surveys assessing the experience of Zimbabwean manufacturers under the country's economic structural adjustment programme (ESAP) from 1990 to 1995. It documents the detailed experiences of selected textile and metal firms under ESAP and concludes that the adjustment framework has caused deindustrialization. ESAP also took a heavy toll on the living and working conditions of manufacturing sector workers. The report makes a strong case for the abandonment of the orthodox structural adjustment framework of industrial restructuring and the pursuit of an alternative approach that is more favourable to the local accumulation of capital.
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  • Resultat 1-4 av 4

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