SwePub
Sök i SwePub databas

  Utökad sökning

Träfflista för sökning "WFRF:(Saemann E. O.) "

Sökning: WFRF:(Saemann E. O.)

  • Resultat 1-3 av 3
Sortera/gruppera träfflistan
   
NumreringReferensOmslagsbildHitta
1.
  • Acharya, B. S., et al. (författare)
  • Introducing the CTA concept
  • 2013
  • Ingår i: Astroparticle physics. - : Elsevier BV. - 0927-6505 .- 1873-2852. ; 43, s. 3-18
  • Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
    • The Cherenkov Telescope Array (CTA) is a new observatory for very high-energy (VHE) gamma rays. CTA has ambitions science goals, for which it is necessary to achieve full-sky coverage, to improve the sensitivity by about an order of magnitude, to span about four decades of energy, from a few tens of GeV to above 100 TeV with enhanced angular and energy resolutions over existing VHE gamma-ray observatories. An international collaboration has formed with more than 1000 members from 27 countries in Europe, Asia, Africa and North and South America. In 2010 the CTA Consortium completed a Design Study and started a three-year Preparatory Phase which leads to production readiness of CTA in 2014. In this paper we introduce the science goals and the concept of CTA, and provide an overview of the project. (C) 2013 Elsevier B.V. All rights reserved.
  •  
2.
  • Hibar, Derrek P., et al. (författare)
  • Novel genetic loci associated with hippocampal volume
  • 2017
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
  • Tidskriftsartikel (refereegranskat)abstract
    • The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
  •  
3.
  • Satizabal, Claudia L., et al. (författare)
  • Genetic architecture of subcortical brain structures in 38,851 individuals
  • 2019
  • Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:11, s. 1624-
  • Tidskriftsartikel (refereegranskat)abstract
    • Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
  •  
Skapa referenser, mejla, bekava och länka
  • Resultat 1-3 av 3
Typ av publikation
tidskriftsartikel (3)
Typ av innehåll
refereegranskat (2)
övrigt vetenskapligt/konstnärligt (1)
Författare/redaktör
Franke, Barbara (2)
Westman, Eric (2)
Tsolaki, Magda (2)
Ching, Christopher R ... (2)
Agartz, Ingrid (2)
Brouwer, Rachel M (2)
visa fler...
Melle, Ingrid (2)
Westlye, Lars T (2)
Thompson, Paul M (2)
Andreassen, Ole A (2)
Andersson, Micael (2)
Axelsson, Tomas (2)
van der Wee, Nic J. ... (2)
Ikram, M. Arfan (2)
Amin, Najaf (2)
van Duijn, Cornelia ... (2)
Chen, Qiang (2)
Rotter, Jerome I. (2)
Soininen, Hilkka (2)
Weinberger, Daniel R (2)
de Geus, Eco J. C. (2)
Martin, Nicholas G. (2)
Boomsma, Dorret I. (2)
Heslenfeld, Dirk J. (2)
van der Meer, Dennis (2)
Djurovic, Srdjan (2)
Doan, Nhat Trung (2)
Meyer-Lindenberg, An ... (2)
Thalamuthu, Anbupala ... (2)
Cichon, Sven (2)
Rietschel, Marcella (2)
Schofield, Peter R (2)
Schmidt, Reinhold (2)
Schmidt, Helena (2)
Deary, Ian J (2)
Mattheisen, Manuel (2)
Wassink, Thomas H (2)
Lopez, Oscar L. (2)
Montgomery, Grant W. (2)
Heinz, Andreas (2)
Le Hellard, Stephani ... (2)
Fornage, Myriam (2)
Homuth, Georg (2)
Launer, Lenore J (2)
Francks, Clyde (2)
Hofman, Albert (2)
Uitterlinden, André ... (2)
Psaty, Bruce M (2)
Gudnason, Vilmundur (2)
Ames, David (2)
visa färre...
Lärosäte
Uppsala universitet (3)
Umeå universitet (2)
Karolinska Institutet (2)
Kungliga Tekniska Högskolan (1)
Stockholms universitet (1)
Lunds universitet (1)
visa fler...
Linnéuniversitetet (1)
visa färre...
Språk
Engelska (3)
Forskningsämne (UKÄ/SCB)
Naturvetenskap (2)
Medicin och hälsovetenskap (2)

År

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy