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| 2. |
- Hudson, Thomas J., et al.
(författare)
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International network of cancer genome projects
- 2010
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7291, s. 993-998
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Tidskriftsartikel (refereegranskat)abstract
- The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
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| 3. |
- Koch, Christian, 1958, et al.
(författare)
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Understanding operations strategizing in project-based organisations: middle managers’ interaction and strategy praxis
- 2015
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Ingår i: Engineering Project Organization Journal. - : Engineering Project Organization Society. - 2157-3735 .- 2157-3727. ; 5:2-3, s. 106-117
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Tidskriftsartikel (refereegranskat)abstract
- The study of operations strategy (OS) in production organisations has largely focused on the content of highlevelstrategies, and less on their practical enactment. Little attention has been paid to the middle managerswho mediate the space between the strategic intent of production organisations and their operational realities.The role and strategic agency of such managers has been shown to be influential in shaping, impeding andenabling OS, but they remain surprisingly absent from much project organisation literature. In this paper, weexamine the role of middle managers in OS practice via a Strategy-as-Practice framework. We study twoproject-based organisations, one in Denmark and one in UK, developing lean production processes. In theDanish case, the change strategy was initiated bottom-up from the project actors, whereas in the UK, thechange strategy was imposed top-down as a strategic management initiative. In both cases, middle managersplayed a crucial role in mediating and translating intention. We show how strategy praxis, and the leadershipof operations, is highly distributed within project-based organisations regardless of where change is initiatedfrom. The findings have resonances for theory on the agency of middle managers, and for the understandingof micro activities of OS formulation and implementation within project-based forms of organisation.
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| 4. |
- Leebens-Mack, James H., et al.
(författare)
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One thousand plant transcriptomes and the phylogenomics of green plants
- 2019
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 574:7780, s. 679-
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Tidskriftsartikel (refereegranskat)abstract
- Green plants (Viridiplantae) include around 450,000-500,000 species(1,2) of great diversity and have important roles in terrestrial and aquatic ecosystems. Here, as part of the One Thousand Plant Transcriptomes Initiative, we sequenced the vegetative transcriptomes of 1,124 species that span the diversity of plants in a broad sense (Archaeplastida), including green plants (Viridiplantae), glaucophytes (Glaucophyta) and red algae (Rhodophyta). Our analysis provides a robust phylogenomic framework for examining the evolution of green plants. Most inferred species relationships are well supported across multiple species tree and supermatrix analyses, but discordance among plastid and nuclear gene trees at a few important nodes highlights the complexity of plant genome evolution, including polyploidy, periods of rapid speciation, and extinction. Incomplete sorting of ancestral variation, polyploidization and massive expansions of gene families punctuate the evolutionary history of green plants. Notably, we find that large expansions of gene families preceded the origins of green plants, land plants and vascular plants, whereas whole-genome duplications are inferred to have occurred repeatedly throughout the evolution of flowering plants and ferns. The increasing availability of high-quality plant genome sequences and advances in functional genomics are enabling research on genome evolution across the green tree of life.
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| 5. |
- Opgenoorth, Hermann J., et al.
(författare)
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Earth's geomagnetic environment : progress and gaps in understanding, prediction, and impacts
- 2024
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Ingår i: Advances in Space Research. - : Elsevier. - 0273-1177 .- 1879-1948.
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Tidskriftsartikel (refereegranskat)abstract
- Understanding of Earth's geomagnetic environment is critical to mitigating the space weather impacts caused by disruptive geoelectric fields in power lines and other conductors on Earth's surface. These impacts are the result of a chain of processes driven by the solar wind and linking Earth's magnetosphere, ionosphere, thermosphere and Earth's surface. Tremendous progress has been made over the last two decades in understanding the solar wind driving mechanisms, the coupling mechanisms connecting the magnetically controlled regions of near-Earth space, and the impacts of these collective processes on human technologies on Earth's surface. Studies of solar wind drivers have been focused on understanding the responses of the geomagnetic environment to spatial and temporal variations in the solar wind associated with Coronal Mass Ejections, Corotating Interaction Regions, Interplanetary Shocks, High-Speed Streams, and other interplanetary magnetic field structures. Increasingly sophisticated numerical models are able to simulate the magnetospheric response to the solar wind forcing associated with these structures. Magnetosphere-ionosphere-thermosphere coupling remains a great challenge, although new observations and sophisticated models that can assimilate disparate data sets have improved the ability to specify the electrodynamic properties of the high latitude ionosphere. The temporal and spatial resolution needed to predict the electric fields, conductivities, and currents in the ionosphere is driving the need for further advances. These parameters are intricately tied to auroral phenomena—energy deposition due to Joule heating and precipitating particles, motions of the auroral boundary, and ion outflow. A new view of these auroral processes is emerging that focuses on small-scale structures in the magnetosphere and their ionospheric effects, which may include the rapid variations in current associated with geomagnetically induced currents and the resulting perturbations to geoelectric fields on Earth's surface. Improvements in model development have paralleled the advancements in understanding, yielding coupled models that better replicate the spatial and temporal scales needed to simulate the interconnected domains. Many realizations of such multi-component systems are under development, each with its own limitations and advantages. Challenges remain in the ability of models to quantify uncertainties introduced by propagation of solar wind parameters, to account for numerical effects in model codes, and to handle the special conditions occurring during extreme events. The impacts to technical systems on the ground are highly sensitive to the local electric properties of Earth's surface, as well as to the specific technology at risk. Current research is focused on understanding the characteristics of geomagnetic disturbances that are important for geomagnetically induced currents, the development of earth conductivity models, the calculation of geoelectric fields, and the modeling of induced currents in the different affected systems. Assessing and mitigating the risks to technical systems requires quantitative knowledge of the range of values to be expected under all possible geomagnetic and technical conditions. Considering the progress that has been made in studying the chain of events leading to hazardous geomagnetic disturbances, the path forward will require concerted efforts to reveal missing physics, improve modeling capabilities, and deploy new observational assets. New understanding should be targeted to accurately quantify solar wind driving, magnetosphere-ionosphere-thermosphere coupling, and the impacts on specific technologies. The research, modeling, and observations highlighted here provide a framework for constructing a plan by which the international science community can comprehensively address the growing threat to human technologies caused by geomagnetic disturbances.
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