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Sökning: WFRF:(Sagnelli Domenico)

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1.
  • Hansen, Lea B.S., et al. (författare)
  • A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
  • 2018
  • Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723 .- 2041-1723. ; 9:1
  • Tidskriftsartikel (refereegranskat)abstract
    • © 2018, The Author(s). Adherence to a low-gluten diet has become increasingly common in parts of the general population. However, the effects of reducing gluten-rich food items including wheat, barley and rye cereals in healthy adults are unclear. Here, we undertook a randomised, controlled, cross-over trial involving 60 middle-aged Danish adults without known disorders with two 8-week interventions comparing a low-gluten diet (2 g gluten per day) and a high-gluten diet (18 g gluten per day), separated by a washout period of at least six weeks with habitual diet (12 g gluten per day). We find that, in comparison with a high-gluten diet, a low-gluten diet induces moderate changes in the intestinal microbiome, reduces fasting and postprandial hydrogen exhalation, and leads to improvements in self-reported bloating. These observations suggest that most of the effects of a low-gluten diet in non-coeliac adults may be driven by qualitative changes in dietary fibres.
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2.
  • Sagnelli, Domenico, et al. (författare)
  • Green enzymatic synthesis and processing of poly (cis-9,10-epoxy-18-hydroxyoctadecanoic acid) in supercritical carbon dioxide (scCO(2))
  • 2021
  • Ingår i: European Polymer Journal. - : Elsevier BV. - 0014-3057 .- 1873-1945. ; 161, s. 110827-
  • Tidskriftsartikel (refereegranskat)abstract
    • There is significant potential for industrial use of renewables for a wide range of materials demanded by society. Plants, trees and algae are increasingly attracting attention as sustainable sources for functionalised and polymerizable building blocks. In particular, the outer bark of the birch tree (Betula pendula) is a side stream of the forestry industry with so far very little utilisation besides energy recovery. It is composed of a macromolecular network, suberin, that could provide a renewable, low cost and competitive resource. Within raw suberin is the potentially very useful multifunctional extract cis-9,10-epoxy-18-hydroxyoctadecanoic acid (CHA). Our drive has been to develop a green and sustainable synthetic strategy to CHA-based polyesters, by exploiting supercritical carbon dioxide (scCO2) as a reaction medium and leveraging the regio- and chemo-selective properties of the biocatalyst Novozym 435 (Lipase B). Low temperature (35-55 degrees C) polycondensation in scCO2 shows significant advantages compared to traditional polymerisation methods leading to reasonably high molecular weight polyesters. The mild synthetic conditions also preserve the valuable epoxy groups of the CHA which we show can be exploited by post-polymerisation functionalisation to create sustainable resins for bio-renewable coatings.
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