| 1. |
- Edman, Anna, et al.
(författare)
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HOME Vatten i Bottenvikens vattendistrikt. Integrerat modellsystem för vattenkvalitetsberäkningar
- 2008
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- SMHI har utvecklat ett interaktivt modellsystem för vattenkvalitetsberäkningar i mark, sjöar,vattendrag och kustvatten, HOME Vatten. I detta uppdrag har HOME Vatten implementerats iBottenvikens vattendistrikt. De ingående modellerna i HOME Vatten är HBV-NP modellen förmark, sjöar och vattendrag samt Kustzonsmodellen för kustvattnen. Atmosfärsdepositionen bådepå land och i kustområdet beräknas av den atmosfärskemiska MATCH-modellen.HOME Vatten har utvecklats för att vara ett verktyg i svensk vattenförvaltning med speciellt fokuspå EUs ramdirektiv för vatten.Modelluppsättningen i kustvatten har validerats mot tillgängliga mätdata, och visar överlag en godöverrensstämmelse med data. Dock saknas i flera fall mätdata över salthalt och närsalthalter vilketförsvårar möjligheterna att dra några slutsatser om modellkvalitén.Längs delar av kuststräckan förekommer inget kustvattenkontrollprogram, varför modellen inte harkunnat valideras där.
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| 2. |
- Hjerdt, Niclas; Lundholm, Karen; Marmefelt, Eleonor; Sahlberg, Jörgen,
(författare)
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HOME Vatten i Bottenhavets vattendistrikt. Integrerat modellsystem för vattenkvalitetsberäkningar
- 2008
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- SMHI har utvecklat ett interaktivt modellsystem för vattenkvalitetberäkningar i mark, sjöar,vattendrag och kustvatten, HOME Vatten. I detta uppdrag har HOME Vatten implementerats iBottenhavets vattendistrikt, dvs. i Västerbotten, Jämtland, Västernorrland, Dalarna, Gävleborg ochUppsala län. De ingående modellerna i HOME Vatten är HBV-NP (PLC5-uppsättningen) modellenför mark, sjöar och vattendrag samt Kustzonsmodellen för kustvattnen. Atmosfärsdepositionenbåde på land och i kustområdet beräknas av den atmosfärskemiska MATCH-modellen.HOME Vatten har utvecklats för att vara ett verktyg i svensk vattenförvaltning med speciellt fokuspå EUs ramdirektiv för vatten.Modelluppsättningarna i Västerbotten, Västernorrland och Gävleborg läns kustvatten harvaliderats mot tillgängliga mätdata, och visar en god överrensstämmelse med data.
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| 3. |
- Humborg, Christoph, et al.
(författare)
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Nutrient variations in boreal and subarctic Swedish rivers : Landscape control of land–sea fluxes
- 2004
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Ingår i: Limnology and Oceanography. - 0024-3590 .- 1939-5590. ; 49:5, s. 1871-1883
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Tidskriftsartikel (refereegranskat)abstract
- We examined the hypothesis that the extent of vegetation cover governs the fluxes of nutrients from boreal and subarctic river catchments to the sea. Fluxes of total organic carbon (TOC) and dissolved inorganic nitrogen, phosphorus, and dissolved silicate (DIN, DIP, and DSi, respectively) are described from 19 river catchments and subcatchments (ranging in size from 34 to 40,000 km2) in northern Sweden with a detailed analysis of the rivers Lulea¨lven and Kalixa¨lven. Fluxes of TOC, DIP, and DSi increase by an order of magnitude with increasing proportion of forest and wetland area, whereas DIN did not follow this pattern but remained constantly low. Principal component analysis on landscape variables showed the importance of almost all land cover and soil type variables associated with vegetation, periglacial environment, soil and bedrock with slow weathering rates, boundary of upper tree line, and percentage of lake area. A cluster analysis of the principal components showed that the river systems could be separated into mountainous headwaters and forest and wetland catchments. This clustering was also valid in relation to river chemistry (TOC, DIP, and DSi) and was confirmed with a redundancy analysis, including river chemistry and principal components as environmental variables. The first axis explains 89% of the variance in river chemistry and almost 100% of the variance in the relation between river chemistry and landscape variables. These results suggest that vegetation change during interglacial periods is likely to have had a major effect on inputs of TOC, DIP, and DSi into the past ocean.
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| 4. |
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| 7. |
- Nordberg, Erika, et al.
(författare)
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Effects of an EGFR-binding affibody molecule on intracellular signaling pathways
- 2010
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Ingår i: International Journal of Oncology. - : Spandidos Publications. - 1019-6439 .- 1791-2423. ; 36:4, s. 967-972
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Tidskriftsartikel (refereegranskat)abstract
- Effects on intracellular signaling were studied in cells treated with the affibody molecule (Z(EGFR:955))(2) that targets the epithelial growth factor receptor (EGFR). EGFR is over-expressed in many types of cancers and plays a fundamental role in cell signaling and it is of interest to find targeting agents capable of blocking the receptor. The clinically approved antibody cetuximab (Erbitux (R)) and the natural ligand EGF were included as reference molecules. Two EGFR-rich cell lines, A-431 and U-343, were exposed to the three targeting agents and lysed. The cell lysates were immunoprecipitated with the receptors, or directly separated by SDS-Pace. Autophosphorylation of the receptors and phosphorylation of the downstream signaling proteins Erk and Akt, were evaluated by Western blotting. Although the three different agents compete for the same binding site on EGFR, they influenced the signaling differently. The affibody molecule did not induce autophosphorylation of EGFR or my other receptor in the EGFR-family but, in spite of this, induced phosphorylation of Erk in both cell lines and Akt in the A-431 cells. Thus, the results suggest that the signaling pattern induced by (Z(EGFR:955))(2) is only partly similar to that induced by cetuximab. This makes the affibody molecule a potentially interesting alternative to cetuximab for EGFR-targeted therapy since it might give different therapy-related effects on tumor cells and different side effects on normal tissues.
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| 8. |
- Omstedt, Anders, et al.
(författare)
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Measured and numerically-simulated autumn cooling in the Bay of Bothnia
- 1983
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Ingår i: Tellus. Series A, Dynamic meteorology and oceanography. - : Stockholm University Press. - 0280-6495 .- 1600-0870. ; 35A:3, s. 231-240
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Tidskriftsartikel (refereegranskat)abstract
- Vertical temperature profiles are analysed for the case of cooling of brackish sea water around the temperature of maximum density. Field measurements in the Bay of Bothnia cover a period of 52 days, during which the surface water was cooled from 6°C to 1.5°C. A mathematical model, which is based on the conservation equations for momentum, heat and salt in their one-dimensional forms, is presented. The equation of state is linear with respect to salinity and quadratic with respect to temperature. Turbulent exchange coefficients are calculated with a two-equation model of turbulence.The measured temperature profiles clearly demonstrate the importance of both temperature and salinity gradients in the mixed-layer dynamics. The mathematical model describes these and the general development of the temperature profile in a most satisfactory way.
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| 9. |
- Sahlberg, Jörgen
(författare)
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A Hydrodynamical Model for Calculating the Vertical Temperature Profile in Lakes During Cooling
- 1983
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Ingår i: Nordic Hydrology. - 0029-1277 .- 1996-9694. ; 14:4, s. 239-254
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Tidskriftsartikel (refereegranskat)abstract
- A one-dimensional hydrodynamical model is used for simulating the vertical temperature profile in a lake during cooling conditions. The vertical mixing rate is calculated by solving the equations for turbulent kinetic energy, k, and dissipation of energy, ε. The heat exchange between the water and atmosphere consists of the radiation fluxes, sensible and latent heat flux. Temperature measurements from Lake Väsman during November-December, 1981, were used in the verification study. The agreement between calculated and measured temperature profiles is very good. This indicates that both the mixing processes and the net heat flux are well described in the model.
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| 10. |
- Sahlberg, Jörgen, et al.
(författare)
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Light limitation of primary production in high latitude reservoirs
- 2005
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Ingår i: Hydrology and Earth System Sciences. - : Copernicus GmbH. - 1027-5606 .- 1607-7938. ; 9:6, s. 707-720
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Tidskriftsartikel (refereegranskat)abstract
- To explore the effects of vertical mixing on the primary production in a northern reservoir, a Lagrangian particle dispersion model was coupled to a 1-D reservoir model where the vertical mixing was calculated using a k - ε model together with an empirically-based deep-water eddy viscosity. The primary production of each phytoplankton cell is assumed to be a function of the ambient light and not to be nutrient limited. The photoadaption follows first-order kinetics where the photoadaptive variables, α, β, and Pm, describe the coefficients of the photosynthesis-irradiance curve. The model is applied to the northern reservoir Akkajaure, which is strongly regulated with a mean and maximum depth of 30 m and 100 m respectively. Based on the release of 1000 particles (plankton), the model calculated the mean primary production of each plankton, during four different growing seasons. Vertical mixing has a substantial effect on the vertical distribution of phytoplankton and, thus, on the primary production in a reservoir. It was found that primary production was greater in a cold summer with weak stratification than in a warm summer when the reservoir was more stratified. © EGU.
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