| 1. |
- Angelin, Anna, et al.
(författare)
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Tvångsvårdade missbrukares hemlöshet
- 2002
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Ingår i: Bostadslöshet som problem och politik : aktuell nordisk forskning (TemaNord, ISSN 0908-6692 ; 2002:558). - 928930815X
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Bredhult, Carolina, et al.
(författare)
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Gene expression analysis of human endometrial endothelial cells exposed to Bisphenol A
- 2009
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Ingår i: Reproductive Toxicology. - : Elsevier BV. - 0890-6238 .- 1873-1708. ; 28:1, s. 18-25
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Tidskriftsartikel (refereegranskat)abstract
- Bisphenol A (BPA) can affect reproductive tissues in several species. Recently, treatment of human endometrial endothelial cells (HEECs) with 100 microM BPA decreased their proliferation and viability. In the present study, 50 microM BPA decreased HEEC proliferation, and microarray analyses of five HEEC cultures revealed that BPA affected biological processes associated with proliferation. Expression of three of the most differentially expressed genes identified in the gene array analysis, SPBC25, SGOL2 and CDCA8, was verified by real-time qRT-PCR in five HEEC cultures obtained from women in the proliferative phase and in five cultures obtained from women in the secretory phase of the menstrual cycle after treatment with BPA. This study supports our previous findings of decreased cell proliferation and increased cell death in response to BPA, and may offer important clues to the mechanisms of action of BPA. Furthermore, the study implies a possible impact of BPA on female fertility functions.
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| 3. |
- Bredhult, Carolina, et al.
(författare)
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Gene expression analysis of human endometrial endothelial cells exposed to o,p'-DDT
- 2008
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Ingår i: Molecular human reproduction. - : Oxford University Press (OUP). - 1360-9947 .- 1460-2407. ; 14:2, s. 97-106
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Tidskriftsartikel (refereegranskat)abstract
- The endocrine disrupting chemical o, p'-dichlorodiphenyltrichloroethane (DDT) can affect reproductive organs, tissues and cells in several species. Treatment of human endometrial endothelial cells (HEECs) with 50 mu M o, p'0- DDT decreased their proliferation compared with the control. Microarray analyses revealed that o, p'-DDT affected biological processes such as the cell cycle, cell division, defence response and lipid and steroid metabolism, in cellular components such as the plasma membrane and chromosomes, with molecular functions involved in signalling, receptor and cytokine activity, confirming the results of the proliferation assay. Expression of five of the most differentially expressed genes identified in the microarray analysis was verified by real- time quantitative reverse transcription polymerase chain reaction in five HEEC cultures obtained from women in the proliferative phase and in five cultures obtained from women in the secretory phase of the menstrual cycle after treatment with o, p'- DDT. The present study supports our previous findings of decreased proliferation and increased cell death in response to o, p'- DDT and may offer important clues to the mechanisms of action of o, p'-DDT.
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| 4. |
- Ferm, Ulrika, et al.
(författare)
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Using Talking Mats to support communication in persons with Huntington's disease.
- 2010
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Ingår i: International journal of language & communication disorders / Royal College of Speech & Language Therapists. - : Wiley. - 1460-6984. ; 45:5, s. 523-36
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Tidskriftsartikel (refereegranskat)abstract
- Many individuals with Huntington's disease experience reduced functioning in cognition, language and communication. Talking Mats is a visually based low technological augmentative communication framework that supports communication in people with different cognitive and communicative disabilities.
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| 5. |
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| 6. |
- Jagarlamudi, Krishna Rao, 1980-
(författare)
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The functional roles of the intra-oocyte phosphatidylinositol 3-kinase (PI3K) signaling in controlling follicular development in mice
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The key functions of the mammalian ovary are the production of fertilizable oocytes and thesecretion of steroid hormones. At the time of birth the human ovary is composed of basic unitstermed primordial follicles. Primordial follicles are long-lived structures in the ovary and some ofthem last until the woman reaches menopause. However, the intra-oocyte signaling pathways thatactivate primordial follicles and early follicular development are largely unknown. In this thesis, the functional roles that the phosphatidylinositol 3-kinase (PI3K) signaling pathwayplays in follicular development were investigated. In vivo approaches using genetically modifiedmouse models were used to determine the functions of several members of the PI3K signalingpathway in oocytes and in follicles. The function of Foxo3a, a substrate of Akt, was investigatedby expressing Foxo3a constitutively in oocytes of primary follicles. We found that continuouslyactive Foxo3a in mouse oocytes caused retardation of oocyte growth, resulting in arrest offollicular development. The functions of p27kip1 (p27) were studied using p27-deficient (p27-/-)mice. It was found that p27 suppresses follicle endowment/formation and activation, and that itinduces follicle atresia. The functions of PI3K signaling in oocytes during follicular activationwere also investigated using conditional mutant mice, by disrupting the Pten in oocytes ofprimordial follicles. We found that, all primordial follicles were prematurely activated due toovergrowth of oocytes and these follicles were depleted in young adulthood, causing prematureovarian failure (POF). At the same time, disruption of the Pten from oocytes of primary follicleshad no effect on activation of primordial follicles, and the follicles developed and maturednormally. The results clearly show that the PI3K pathway in the mammalian oocyte plays a keyrole in follicular activation through control of initiation of oocyte growth and folliculardevelopment.
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| 7. |
- Johannesson, Ulrika, et al.
(författare)
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Steroid receptor expression and morphology in provoked vestibulodynia
- 2008
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Ingår i: American Journal of Obstetrics and Gynecology. - St. Louis : C.V. Mosby. - 0002-9378 .- 1097-6868. ; 198:3, s. 311.e1-311.e6
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Tidskriftsartikel (refereegranskat)abstract
- Objective: This study was undertaken to survey the steroid receptor expression and morphology in the vulvar vestibular mucosa in women with provoked vestibulodynia.Study Design: Fourteen patients and 25 controls without oral contraceptives were included. Vestibular biopsy specimens were obtained and analyzed by using immunohistochemistry, followed by computerized image analysis of estrogen receptors greek small letter alpha and β, progesterone receptors A and B, glucocorticoid receptor, androgen receptor, and the proliferation marker Ki67. The morphology was estimated by measuring 4 parameters in the epithelium.Results: There was a significantly higher expression of estrogen receptor greek small letter alpha in both the epithelium (P = .04) and the stroma (P = .02) in the patient specimens compared with the controls. There were no significant differences in the other analyses performed.Conclusion: There is an increased expression of estrogen receptor greek small letter alpha in the vestibular mucosa but the epithelial morphology seems unaffected in women with provoked vestibulodynia. Further studies regarding plausible associations to neurogenic inflammation are needed.
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| 8. |
- Jönbrink, Anna Karin, et al.
(författare)
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Policy for Circular Economy : Prestudy for improved policy development
- 2017
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This paper describes mainly the approach and results from a project “Polcirkeln” within the research program RE:Source, funded by three Swedish agencies: the Swedish Energy Agency, Vinnova and Formas. Polcirceln has studied the current situation and possible future effects of various measures for a circular economy. Among others, the EU's proposed policy package for a circular economy has been studied. A selection of today's flows of products, materials and waste constitutes a starting point and challenges and possible effects on material flows and sustainability have been formulated and analyzed based on experiences and views from different actors in the value chain (mainly from industry), and other experts. Methods used in the study are e.g. interviews, web-surveys, workshops and scenario analysis.The importance of Policies moving towards a more holistic approach to achieve more circular flows has been stressed by all stakeholders in the study described in the paper. Instead of dividing activities, obstacles and opportunities between waste, materials, production and consumption, a holistic approach should be introduced in the analysis of the challenges and designing of solutions. Another main finding is that a change to a Circular Economy needs an increased and developed cooperation between companies and other actors along the value chain, thus there is a need to develop policies in order to support the new improved ways for cooperation
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| 9. |
- Kindblom, Jon, 1969, et al.
(författare)
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Prostate hyperplasia in a transgenic mouse with prostate-specific expression of prolactin.
- 2003
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Ingår i: Endocrinology. - : The Endocrine Society. - 0013-7227 .- 1945-7170. ; 144:6, s. 2269-78
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Tidskriftsartikel (refereegranskat)abstract
- Prolactin (PRL) is one of several polypeptide factors known to exert trophic effects on the prostate. We have previously reported a dramatic prostate enlargement with concurrent chronic hyperprolactinemia and elevated serum androgen levels in a PRL transgenic mouse (Mt-PRL) with ubiquitous expression of the transgene. To address the role of local PRL action in the prostate, a new transgenic mouse model (Pb-PRL) was generated using the prostate-specific rat probasin (Pb) minimal promoter to drive expression of the rat PRL gene. Pb-PRL transgenic males developed a significant enlargement of both the dorsolateral and ventral prostate lobes evident from 10 wk of age and increasing with age. Expression of the transgene was restricted to the prostate and detected from 4 wk of age. Low levels of transgenic rat PRL were detectable in the serum of adult Pb-PRL animals. Serum androgen levels were normal. The Pb-PRL prostate displayed significant stromal hyperplasia, ductal dilation, and focal areas of epithelial dysplasia. Quantitative analysis of prostatic tissue cellularity demonstrated a marked increase in the stromal to epithelial ratio in all lobes of Mt-PRL and Pb-PRL transgenic prostates compared with controls. Microdissections demonstrated an increased ductal morphogenesis in dorsolateral and ventral prostate lobes of Mt-PRL prostate vs. Pb-PRL and controls. In conclusion, this study indicates the ability of PRL to promote, directly or indirectly, ductal morphogenesis in the developing prostate and further to induce abnormal growth primarily of the stroma in the adult gland in a setting of normal androgen levels.
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| 10. |
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