| 1. |
- Drögemüller, Cord, et al.
(författare)
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A mutation in hairless dogs implicates FOXI3 in ectodermal development
- 2008
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 321:5895, s. 1462-
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Tidskriftsartikel (refereegranskat)abstract
- Mexican and Peruvian hairless dogs and Chinese crested dogs are characterized by missing hair and teeth, a phenotype termed canine ectodermal dysplasia (CED). CED is inherited as a monogenic autosomal semidominant trait. With genomewide association analysis we mapped the CED mutation to a 102-kilo-base pair interval on chromosome 17. The associated interval contains a previously uncharacterized member of the forkhead box transcription factor family (FOXI3), which is specifically expressed in developing hair and teeth. Mutation analysis revealed a frameshift mutation within the FOXI3 coding sequence in hairless dogs. Thus, we have identified FOXI3 as a regulator of ectodermal development.
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| 2. |
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| 3. |
- Karvala, Kirsi, et al.
(författare)
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Building-Related Environmental Intolerance and Associated Health in the General Population
- 2018
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1661-7827 .- 1660-4601. ; 15:9
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Tidskriftsartikel (refereegranskat)abstract
- People frequently attribute adverse symptoms to particular buildings when exposure to pollutants is low, within nonhazardous levels. Our aim was to characterize building-related intolerance (BRI) in the general population. Data were derived from two population-based questionnaire surveys, the Vasterbotten and osterbotten Environmental Health Study. We identified cases of BRI if respondents reported symptoms emerging from residing in certain buildings, when most other people had none. The questionnaires covered lifestyle factors, perceived general health, BRI duration and symptom frequency, the emotional and behavioral impact of BRI, coping strategies, and physician-diagnosed diseases. From the total of 4941 participants, we formed two case groups, 275 (5.6%) fulfilled criteria for self-reported BRI, and 123 (2.5%) for BRI with wide-ranging symptoms. Individuals in both case groups were significantly more often female, single, and perceived their general health as poorer than the referents, i.e., those reporting no BRI symptoms. The mean duration of BRI was 12 years. In both case groups, avoidance behavior was found in over 60%, and nearly half of the sample had sought medical care. BRI with wide-ranging symptoms was associated with elevated odds for all studied comorbidities (somatic and psychiatric diseases and functional somatic syndromes). The perceived health of individuals with BRI is poorer and comorbidities are more frequent than among referents. BRI seems to be similar to other environmental intolerances and shares features with functional somatic syndromes.
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| 4. |
- Karvala, Kirsi, et al.
(författare)
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Prevalence of various environmental intolerances in a Swedish and Finnish general population
- 2018
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Ingår i: Environmental Research. - : Academic Press Inc Elsevier Science. - 0013-9351 .- 1096-0953. ; 161, s. 220-228
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Tidskriftsartikel (refereegranskat)abstract
- Objective: To determine the prevalence of various environmental intolerances (EIs), using several criteria in a Swedish and a Finnish general population. Ill-health attributed to low-level environmental exposures is a commonly encountered challenge in occupational and environmental medicine. Methods: In population-based questionnaire surveys, the Vasterbotten Environmental Health Study (Sweden) and the Osterbotten Environmental Health Study (Finland), EI was inquired by one-item questions on symptom attribution to chemicals, certain buildings, or electromagnetic fields (EMFs), and difficulties tolerating sounds. The respondents were asked whether they react with central nervous system (CNS) symptoms or have a physician-diagnosed EI attributed to the corresponding exposures. Prevalence rates were determined for different age and sex groups and the Swedish and Finnish samples in general. Results: In the Swedish sample (n = 3406), 12.2% had self-reported intolerance to chemicals, 4.8% to certain buildings, 2.7% to EMFs, and 9.2% to sounds. The prevalence rates for the Finnish sample (n = 1535) were 15.2%, 7.2%, 1.6%, and 5.4%, respectively, differing statistically significantly from the Swedish. EI to chemicals and certain buildings was more prevalent in Finland, while EI to EMFs and sounds more prevalent in Sweden. The prevalence rates for EI with CNS-symptoms were lower and physician-diagnosed EIs considerably lower than self-reported EIs. Women reported EI more often than men and the young (18-39 years) to a lesser degree than middle-aged and elderly. Conclusions: The findings reflect the heterogeneous nature of EI. The differences in EI prevalence between the countries might reflect disparities concerning which exposures people perceive harmful and focus their attention to.
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| 5. |
- Nordin, Steven, 1960-, et al.
(författare)
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Prevalence of environmental annoyance in a Swedish and Finnish general population : Impact of everyday exposures on affect and behavior
- 2018
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Ingår i: Journal of Environmental Psychology. - : Elsevier. - 0272-4944 .- 1522-9610. ; 56, s. 84-90
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Tidskriftsartikel (refereegranskat)abstract
- We identified optimal cutoff scores for three questionnaire instruments that quantify environmental annoyance (affective reactions and behavioral disruptions) attributed to everyday environmental exposures of chemicals, electromagnetic fields and sounds, and applied these cutoff scores to estimate the prevalence of such reactions in two general populations. Data were used from 4941 participants from Swedish and Finnish population-based surveys. The identified optimal cutoff scores showed excellent diagnostic accuracy, and provided prevalence rates for these reactions of 28.8 and 27.0% for chemicals, 7.0 and 7.7% for electromagnetic fields, and 27.8 and 28.3% for sounds, for the Swedish and Finnish samples, respectively. The prevalence rates varied between age groups and sexes. The findings suggest that the cutoffs are useful for identifying individuals or groups with affective and behavioral reactions to everyday environmental exposures, and that the prevalence rate for these reactions vary depending on type of exposure, age and sex.
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