| 1. |
- Chen, H.Y., et al.
(författare)
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Dyslipidemia, inflammation, calcification, and adiposity in aortic stenosis: a genome-wide study
- 2023
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Ingår i: European Heart Journal. - : Oxford University Press. - 0195-668X .- 1522-9645. ; 44:21, s. 1927-1939
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Tidskriftsartikel (refereegranskat)abstract
- Aims Although highly heritable, the genetic etiology of calcific aortic stenosis (AS) remains incompletely understood. The aim of this study was to discover novel genetic contributors to AS and to integrate functional, expression, and cross-phenotype data to identify mechanisms of AS. Methods and results A genome-wide meta-analysis of 11.6 million variants in 10 cohorts involving 653 867 European ancestry participants (13 765 cases) was performed. Seventeen loci were associated with AS at P ≤ 5 × 10−8, of which 15 replicated in an independent cohort of 90 828 participants (7111 cases), including CELSR2–SORT1, NLRP6, and SMC2. A genetic risk score comprised of the index variants was associated with AS [odds ratio (OR) per standard deviation, 1.31; 95% confidence interval (CI), 1.26–1.35; P = 2.7 × 10−51] and aortic valve calcium (OR per standard deviation, 1.22; 95% CI, 1.08–1.37; P = 1.4 × 10−3), after adjustment for known risk factors. A phenome-wide association study indicated multiple associations with coronary artery disease, apolipoprotein B, and triglycerides. Mendelian randomization supported a causal role for apolipoprotein B-containing lipoprotein particles in AS (OR per g/L of apolipoprotein B, 3.85; 95% CI, 2.90–5.12; P = 2.1 × 10−20) and replicated previous findings of causality for lipoprotein(a) (OR per natural logarithm, 1.20; 95% CI, 1.17–1.23; P = 4.8 × 10−73) and body mass index (OR per kg/m2, 1.07; 95% CI, 1.05–1.9; P = 1.9 × 10−12). Colocalization analyses using the GTEx database identified a role for differential expression of the genes LPA, SORT1, ACTR2, NOTCH4, IL6R, and FADS. Conclusion Dyslipidemia, inflammation, calcification, and adiposity play important roles in the etiology of AS, implicating novel treatments and prevention strategies. © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.
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| 2. |
- Fejes, Andreas, 1977-, et al.
(författare)
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Envisioning future research on the education and learning of adults
- 2010
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Ingår i: European Journal for Research on the Education and Learning of Adults. - Linköping : Linköping University Electronic Press. - 2000-7426. ; 1:1-2, s. 7-16
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Tidskriftsartikel (refereegranskat)abstract
- Establishing a new scholarly journal can be justified by the functional needs of a welldefined scientific discipline – or as opposition to its institutional and paradigmatic framework. This is, however, not the case with the European Journal for Research on the Education and Learning of Adults (RELA). It is, rather, so that the journal is part of the emergence of a scientific community, very deeply embedded in societal practices at the same time as it is reconstructing intellectually these practices and their context as scientific objects. In this case, the journal can attempt to provide an arena and some of the communicative resources for academic and broader social development of such a community. To fulfil this mission, its rationale and specific goals are equally related to a diagnosis of these societal practices and some visions for the role of scientific inquiry in these practices. As two of the six editors of RELA, and responsible for the editorial work of the first issue of the journal, we will discuss why this journal has been launched, and how the editors want to position it in the area of the education and learning of adults.
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| 3. |
- Fejes, Andreas, 1977-, et al.
(författare)
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European Journal for Research on the Education and Learning of Adults : A contribution to diversity in the European academic landscape
- 2011
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Ingår i: Curating the European University. - Leuven : Leuven University. - 9789058678744
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- The university is an institution invented during the Middle Ages. As universitas magistrorum et scholariumthe university was a specific community or association of scholars and students gathered around books and preoccupied with study and the search for truth. But what is the role of the university today?The meaning of teaching, study and research has changed with books being replaced by screens, with online learning environments replacing lecture halls and students becoming learners. In the light of a growing emphasis on innova-tion and development, competitiveness between institutions and the privatisation of knowledge, the role of communities of scholars and students is clearly changing. Some argue that the university enters a new phase, while others claim that we actually face the end of the age of the university.In order to address these issues, a conference was organized around an exposition of projects that present new ways of publishing, an alternative organization of a department, initiatives related to open access and open source, university architecture and accessibility ... Taking as a point of departure their exhibited pro-ject, each of the contributors to Curating the European University reflects on the current challenges the university is facing today with a specific focus on its public role. The book, being at the same time a catalogue, includes textual and graphic descriptions of different projects, and offers a unique contribution to the public debate on the role of the university.
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| 4. |
- Fejes, Andreas, 1977-, et al.
(författare)
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Marketization and Commodification of Adult Education
- 2016
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Ingår i: European Journal for Research on the Education and Learning of Adults. - : Linköping University Electronic Press. - 2000-7426. ; 7:2, s. 146-150
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 5. |
- Fejes, Andreas, 1977-, et al.
(författare)
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RELAs 10-year anniversary : What have we accomplished?
- 2019
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Ingår i: European Journal for Research on the Education and Learning of Adults. - : Linkoping University Electronic Press. - 2000-7426. ; 10:1, s. 7-12
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The first issue of RELA was published in 2010, so with this issue we enter the 10-year anniversary. In this editorial, we will firstly elaborate on what we as editors find that RELA has accomplished. Secondly, we introduce changes that are taking place while entering 2019, and lastly, we introduce the papers which are included in this issue.
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