| 1. |
- Gabi, Danlami, et al.
(författare)
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Cloud customers service selection scheme based on improved conventional cat swarm optimization
- 2020
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Ingår i: Neural Computing & Applications. - : Springer. - 0941-0643 .- 1433-3058. ; 32, s. 14817-14838
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Tidskriftsartikel (refereegranskat)abstract
- With growing demand on resources situated at the cloud datacenters, the need for customers' resource selection techniques becomes paramount in dealing with the concerns of resource inefficiency. Techniques such as metaheuristics are promising than the heuristics, most especially when handling large scheduling request. However, addressing certain limitations attributed to the metaheuristic such as slow convergence speed and imbalance between its local and global search could enable it become even more promising for customers service selection. In this work, we propose a cloud customers service selection scheme called Dynamic Multi-Objective Orthogonal Taguchi-Cat (DMOOTC). In the proposed scheme, avoidance of local entrapment is achieved by not only increasing its convergence speed, but balancing between its local and global search through the incorporation of Taguchi orthogonal approach. To enable the scheme to meet customers' expectations, Pareto dominant strategy is incorporated providing better options for customers in selecting their service preferences. The implementation of our proposed scheme with that of the benchmarked schemes is carried out on CloudSim simulator tool. With two scheduling scenarios under consideration, simulation results show for the first scenario, our proposed DMOOTC scheme provides better service choices with minimum total execution time and cost (with up to 42.87%, 35.47%, 25.49% and 38.62%, 35.32%, 25.56% reduction) and achieves 21.64%, 18.97% and 13.19% improvement for the second scenario in terms of execution time compared to that of the benchmarked schemes. Similarly, statistical results based on 95% confidence interval for the whole scheduling scheme also show that our proposed scheme can be much more reliable than the benchmarked scheme. This is an indication that the proposed DMOOTC can meet customers' expectations while providing guaranteed performance of the whole cloud computing environment.
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| 2. |
- Kooner, Jaspal S, et al.
(författare)
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Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.
- 2011
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 43:10
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Tidskriftsartikel (refereegranskat)abstract
- We carried out a genome-wide association study of type-2 diabetes (T2D) in individuals of South Asian ancestry. Our discovery set included 5,561 individuals with T2D (cases) and 14,458 controls drawn from studies in London, Pakistan and Singapore. We identified 20 independent SNPs associated with T2D at P < 10(-4) for testing in a replication sample of 13,170 cases and 25,398 controls, also all of South Asian ancestry. In the combined analysis, we identified common genetic variants at six loci (GRB14, ST6GAL1, VPS26A, HMG20A, AP3S2 and HNF4A) newly associated with T2D (P = 4.1 × 10(-8) to P = 1.9 × 10(-11)). SNPs at GRB14 were also associated with insulin sensitivity (P = 5.0 × 10(-4)), and SNPs at ST6GAL1 and HNF4A were also associated with pancreatic beta-cell function (P = 0.02 and P = 0.001, respectively). Our findings provide additional insight into mechanisms underlying T2D and show the potential for new discovery from genetic association studies in South Asians, a population with increased susceptibility to T2D.
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| 3. |
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| 4. |
- Rahman, Heshu Sulaiman, et al.
(författare)
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Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications
- 2020
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Ingår i: International Journal of Nanomedicine. - 1176-9114 .- 1178-2013. ; 15, s. 2439-2483
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Forskningsöversikt (refereegranskat)abstract
- Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications.
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| 5. |
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| 6. |
- Zarli, Alain, et al.
(författare)
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A strategic and comprehensive vision for future R&D in construction ICT
- 2007
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Ingår i: Bringing ITC knowledge to work : Proceedings of the W78 Conference, Maribor 2007 - Proceedings of the W78 Conference, Maribor 2007. ; , s. 263-270
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Konferensbidrag (refereegranskat)abstract
- The tremendous development in the past ten last years of the Internet and ICT at large (whether it be in general technologies like semantic modeling, knowledge mining, RFID or mobile technologies, or domain-oriented ones like e-commerce, collaborative spaces, digital mock-ups, etc.) has opened a large spectrum of potential applica-tions of ICT in the Construction sector. The real adaptation and deployment of ICT in Construction has indeed just started, and there is a high need to organize and plan future R&D actions for Construction ICT, while at the same time to better evaluate the benefits and thereby convince Construction actors. This is the role of the Strat-CON and BICT projects, respectively, which are introduced in this article in terms of their aims and major results.
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