| 1. |
- Giri, Sandip, et al.
(författare)
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Economic incentives drive the conversion of agriculture to aquaculture in the Indian Sundarbans : Livelihood and environmental implications of different aquaculture types
- 2022
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Ingår i: Ambio. - : Springer Science and Business Media LLC. - 0044-7447 .- 1654-7209. ; 51:9, s. 1963-1977
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Tidskriftsartikel (refereegranskat)abstract
- Expansion of aquaculture in the Sundarbans Biosphere Reserve (SBR) is irreversibly replacing agricultural land and the drivers of this change are disputed. Based on in-depth interviews with 67 aquaculture farmers, this paper characterizes major aquaculture types in the SBR, their impacts, and identifies drivers of conversion from agricultural land. Aquaculture types included traditional, improved-traditional, modified-extensive, and semi-intensive systems. Extensive capture of wild shrimp larvae is environmentally harmful but constitutes an important livelihood. Semi-intensive aquaculture of exotic shrimp (Litopenaeus vannamei) has much higher unit-area profitability than other types but involves greater financial risk. Profitability is the main driver for the transition from agriculture, but environmental factors such as lowered crop yields and cyclone impacts also contributed. Many conversions from agriculture to aquaculture are illegal according to the stakeholders. Existing legislation, if enforced, could halt the loss of agriculture, while the promotion of improved-traditional aquaculture could reduce the demand for wild seed.
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| 2. |
- Rajasekhar, Kolla, et al.
(författare)
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Antioxidant Berberine-Derivative Inhibits Multifaceted Amyloid Toxicity
- 2020
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Ingår i: iScience. - : Elsevier. - 2589-0042. ; 23:4
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Tidskriftsartikel (refereegranskat)abstract
- Multiple lines of evidence indicate that amyloid beta (A beta) peptide is responsible for the pathological devastation caused in Alzheimer's disease (AD). A beta aggregation species predominantly contribute to multifaceted toxicity observed in neuronal cells including generation of reactive oxygen species (ROS), mitochondrial dysfunction, interfering with synaptic signaling, and activation of premature apoptosis. Herein, we report a natural product berberine-derived (Ber-D) multifunctional inhibitor to ameliorate in cellulo multifaceted toxicity of AD. The structural attributes of polyphenolic Ber-D have contributed to its efficient Cu chelation and arresting the redox cycle to prevent the generation of ROS and rescue biomacromolecules from oxidative damage. Ber-D inhibits metal-dependent and -independent A beta aggregation, which is supported by in silico studies. Ber-D treatment averts mitochondrial dysfunction and corresponding neuronal toxicity contributing to premature apoptosis. These key multifunctional attributes make Ber-D a potential therapeutic candidate to ameliorate multifaceted A beta toxicity in AD.
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