| 1. |
- Danielsson, Henrik, Professor, 1974-
(författare)
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Randomiserade kontrollerade studier av interventionsprogram för elever med tidiga läs- och matematiksvårigheter
- 2023
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Ingår i: Resultatdialog 2023. - : Vetenskapsrådet. - 9789189845107 ; , s. 15-18
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Forskningens syfte var att utveckla och utvärdera två interventioner för elever med tidiga lässvårigheter eller tidiga mattesvårigheter. Resultaten visade att bägge interventionerna hade en medelstor till stor effekt på förbättring för interventionsgrupperna direkt efter interventionerna. Ett år efter interventionerna hade de flesta av de positiva effekterna minskat till ungefär hälften.
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| 2. |
- Lindström-Sandahl, Hanna, 1979-, et al.
(författare)
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A randomized controlled study of a second grade numeracy intervention with Swedish students at‐risk of mathematics difficulties
- 2024
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Ingår i: British Journal of Educational Psychology. - : Wiley. - 0007-0998 .- 2044-8279.
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Tidskriftsartikel (refereegranskat)abstract
- Background: Early numeracy interventions including basicarithmetic are crucial for young students at risk for earlymathematics difficulties (MDs), yet few studies have evalu-ated numeracy interventions in second grade with a rand-omized controlled design.Aim: This pre- and post-test randomized controlled studyevaluated the effects of an intensive 9-week numeracy andarithmetic programme for second-grade students at risk forearly MDs. The focus of the programme was students’ foun-dational understanding of numbers and mathematical con-cepts and procedural fluency with arithmetic tasks.Sample: A total of 753 first-grade students from 21 schoolsin Sweden were screened for low achievement in numberknowledge and arithmetic.Methods: Students considered at risk for MDs (≤25 per-centile on two consecutive first-grade mathematics screen-ings) were individually randomized to an intervention group(n = 32) or control group (n = 30) at the beginning of secondgrade (7–8 years old). Trained teachers administered theone-to-one, explicit programme to intervention group stu-dents in elementary school settings. The intervention groupreceived numeracy instruction emphasizing foundationalmathematics concepts and procedures. Controls receivedteaching as usual with potential special education supportprovided by their schools.Results: The intervention group demonstrated significantlygreater improvements in conceptual knowledge, arithmeticcalculations and problem-solving compared to the controlgroup, with medium size effects observed.
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| 3. |
- Lindström-Sandahl, Hanna, 1979-
(författare)
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Early Elementary School Interventions in Reading and Mathematics
- 2024
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Supplemental special education support in reading and mathematics is essential for some children who struggle to learn basic reading or mathematics skills in their first years of schooling. Previous research shows that supplemental phonics and early numeracy and arithmetic instruction help students at risk for reading or mathematics difficulties. Few intervention studies have been conducted in the Swedish elementary school context evaluating the effectiveness of early reading and mathematics instruction, limiting evidence-based practices guiding special education in Sweden. This thesis aimed to develop and test the impact of two intensive instructional programs on word reading and reading comprehension skills and number knowledge, arithmetic and problem solving. Transfer-effects of training across the reading and mathematics domains and the long-term impact of the programs were also investigated. The study enrolled 753 first grade students who were screened for low performance (≤25th percentile) in decoding, spelling, number knowledge and arithmetic. To evaluate how the impact of the interventions differ from regular school instruction, students were randomized to intervention and control groups and pre-tested with extended assessment of reading and mathematics skills (n=32 vs. 30 in mathematics, n=34 vs. 34 in reading). Both interventions were implemented at the start of second grade. The intervention programs spanned 36 lessons of supplemental explicit, one-to-one instruction with a special education teacher. Control group students received support planned by their schools. The results were evaluated at post-test and followed-up after 1 year. Both programs indicated significant intervention effects at post-test compared with controls with the reading intervention showing medium impact on decoding and reading comprehension and a strong effect on word recognition. The mathematics intervention program displayed significant moderate impact on number knowledge, arithmetic and basic problem solving. For both interventions, these effects declined at follow-up one year later. In addition, no transfer across reading and mathematics interventions were found. A main conclusion drawn from these randomized controlled studies is that students’ performance in basic reading and mathematics can be substantially accelerated by a time-limited and intense effort, adding to the evidence-base of explicit phonics and early numeracy and arithmetic intervention as recommended practices also in a Swedish school context. As many previous studies have shown, intervention gains tend to fade over time. The longevity of intensive intervention impacts should be considered in post-intervention efforts to support learning. Alignment between supplemental programs and general classroom instruction is suggested.
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| 4. |
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| 5. |
- Ytreberg, Agnes, et al.
(författare)
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God havsmiljö 2020 : Marin strategi för Nordsjön och Östersjön Del 3: Övervakningsprogram
- 2014
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Havsmiljöförordningens övergripande mål är att upprätthålla eller uppnå en god miljöstatus i de svenska förvaltningsområdena Nordsjön och Östersjön till år 2020. En av uppgifterna i den första förvaltningsperioden är att fastställa övervakningsprogram.God miljöstatus baseras på ett ramverk av så kallade deskriptorer som anges i havsmiljödirektivet, det vill säga det EU-direktiv som i Sverige genomförs genom havsmiljöförordningen. Deskriptorerna beskriver god miljöstatus på en övergripande nivå för elva temaområden. Till varje deskriptor hör en rad kriterier som anger vad som ska ingå i en bedömning av miljöstatus. Utifrån de elva deskriptorerna har Sverige fastställt 13 övervakningsprogram. Sex program utgår ifrån olika biodiversitetsteman som berörs av en upp till tre deskriptorer, medan de övriga sju programmen utgår ifrån de deskriptorer som är mer inriktade mot belastning och miljöförändring.För varje program har ett antal underprogram föreslagits baserat på den nuvarande övervakningen och/eller planerad övervakning. Övervakning som ingår i programmen ska vara pågående och data ska vara tillgängliga. I programmen ingår nationell och regional miljöövervakning inklusive verksamhetsutövares recipientkontroll. Dessutom ingår annan typ av datainsamling som till exempel inventeringar av tumlare och uppgifter om omfattningen av mänskliga aktiviteter som orsakar belastning och miljöförändringar. Enligt havsmiljödirektivet ska övervakningen fånga upp tillstånd och miljöförändringar, belastning och omfattning av aktiviteterna som orsakar belastningen samt effekter av åtgärder. Eftersom nästa steg i havsförvaltningscykeln är att fastställa åtgärdsprogram kommer övervakning för att följa upp åtgärder att läggas till övervakningsprogrammen först under nästa förvaltningscykel.I beskrivningarna av programmen framgår hur den nuvarande övervakningen motsvarar de krav som ställs på dataunderlag genom havsmiljödirektivets bilaga III samt genom deskriptorer, kriterier, indikatorer och beslutade miljökvalitetsnormer. I dagens övervakning saknas bland annat tillräcklig övervakning för uppföljning av livsmiljöers tillstånd och utbredning. För marint avfall, buller och främmande arter saknas nationellt samordnad övervakning, men det görs regionala insatser och ett antal projekt har genomförts eller påbörjats för att öka kunskapen om hur övervakning bäst ska utformas. För de program som har pågående övervakning beskrivs utvecklingsbehoven för att förbättra underlaget för de återkommande tillståndsbedömningarna.Övervakningsprogrammet som fastställs under 2014 utgör således inte ett fast program för kunskapsinhämtning. Bristerna kommer att beaktas i det fortsatta genomförandet av havsmiljöförordningen där utveckling av indikatorer och övervakning kommer att ske kontinuerligt.
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| 6. |
- Adrian Meredith, Jenny, 1971-, et al.
(författare)
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Design and Synthesis of BACE-1 Inhibitors Containing a New Hydroxyethylene (HE) Scaffold: Potent activities in a cellular assay
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- In a preceding report from our group we disclosed the development of a novel HE transition state isostere with a difluorophenoxymethyl side chain in the P1 position and a methoxy group in the P1’ position furnishing highly potent inhibitors of BACE-1 (i.e. lead compound 1), which moreover exhibit very promising selectivity over cathepsin D. In a continuation of this work with the aim at improving on the cell-based activity and pharmacokinetic properties, we have further developed the SAR for the P1 side chain of inhibitor 1 whereby the P1 side chain oxygen has been substituted for an amine, a carbon or a bond. The chemistry developed for the previous HE inhibitor structure 1 has now been extended to readily accommodate the introduction of new P1 side chains into this new HE scaffold. These modifications have given rise to several highly potent inhibitors where the most potent displayed a BACE-1 Ki value of 0.2 nM and a cell-based Aβ40 IC50 value of 9 nM. Thus, regarding the enzyme inhibition in the cell assay a more than 600-fold improvement compared to compound 1 was achieved via minor structural alterations.
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| 7. |
- Adrian Meredith, Jenny, 1971-, et al.
(författare)
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P2 '-truncated BACE-1 inhibitors with a novel hydroxethylene-like core
- 2010
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Ingår i: European Journal of Medicinal Chemistry. - : Elsevier BV. - 0223-5234 .- 1768-3254. ; 45:2, s. 542-554
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Tidskriftsartikel (refereegranskat)abstract
- Highly potent BACE-1 protease inhibitors derived from a novel hydroxyethylene-like core structure were recently developed by our group using X-ray crystal structure data and molecular modelling. In a continuation of this work guided by molecular modelling we have explored a truncated core motif where the P2' amide group is replaced by an ether linkage resulting in a set of alkoxy, aryloxy and alkylaryl groups, with the overall aim to reduce molecular weight and the number of amide bonds to increase permeability and bestow the inhibitors with drug-like features. The most potent of these inhibitors displayed a BACE-I IC50 value of 140 nM. The synthesis of these BACE-I inhibitors utilizes readily available starting materials, furnishing the target compounds in good overall yields.
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| 10. |
- Beraki, Åsa, et al.
(författare)
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Increase in physical activity is associated with lower HbA1c levels in children and adolescents with type 1 diabetes : results from a cross-sectional study based on the Swedish pediatric diabetes quality registry (SWEDIABKIDS)
- 2014
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Ingår i: Diabetes Research and Clinical Practice. - Clare, Ireland : Elsevier. - 0168-8227 .- 1872-8227. ; 105:1, s. 119-125
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Tidskriftsartikel (refereegranskat)abstract
- Aims: To evaluate the associations between physical activity (PA) and metabolic control, measured by glycated hemoglobin (HbA1c), in a large group of children and adolescents with type 1 diabetes.Methods: Cross-sectional analysis of data from 4655 patients, comparing HbA1c values with levels of physical activity. The data for the children and adolescents were obtained from the Swedish pediatric diabetes quality registry, SWEDIABKIDS. The patients were 7-18 years of age, had type 1 diabetes and were not in remission. Patients were grouped into five groups by frequency of PA.Results: Mean HbA1c level was higher in the least physically active groups (PA0: 8.8% +/- 1.5 (72 +/- 16 mmol/mol)) than in the most physically active groups (PA4: 7.7% +/- 1.0 (60 +/- 11 mmol/mol)) (p < 0.001). An inverse dose-response association was found between PA and HbA1c (beta: -0.30, 95%CI: -0.34 to -0.26, p < 0.001). This association was found in both sexes and all age groups, apart from girls aged 7-10 years. Multiple regression analysis revealed that the relationship remained significant (beta: -0.21, 95% CI: -0.25 to -0.18, p < 0.001) when adjusted for possible confounding factors.Conclusions: Physical activity seems to influence HbA1c levels in children and adolescents with type 1 diabetes. In clinical practice these patients should be recommended daily physical activity as a part of their treatment.
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