| 1. |
- Chatzikonstantinou, T, et al.
(författare)
-
COVID-19 severity and mortality in patients with CLL: an update of the international ERIC and Campus CLL study
- 2021
-
Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 1476-5551 .- 0887-6924. ; 35:12, s. 3444-3454
-
Tidskriftsartikel (refereegranskat)abstract
- Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to Coronavirus disease 2019 (COVID-19) due to age, disease, and treatment-related immunosuppression. We aimed to assess risk factors of outcome and elucidate the impact of CLL-directed treatments on the course of COVID-19. We conducted a retrospective, international study, collectively including 941 patients with CLL and confirmed COVID-19. Data from the beginning of the pandemic until March 16, 2021, were collected from 91 centers. The risk factors of case fatality rate (CFR), disease severity, and overall survival (OS) were investigated. OS analysis was restricted to patients with severe COVID-19 (definition: hospitalization with need of oxygen or admission into an intensive care unit). CFR in patients with severe COVID-19 was 38.4%. OS was inferior for patients in all treatment categories compared to untreated (p < 0.001). Untreated patients had a lower risk of death (HR = 0.54, 95% CI:0.41–0.72). The risk of death was higher for older patients and those suffering from cardiac failure (HR = 1.03, 95% CI:1.02–1.04; HR = 1.79, 95% CI:1.04–3.07, respectively). Age, CLL-directed treatment, and cardiac failure were significant risk factors of OS. Untreated patients had a better chance of survival than those on treatment or recently treated.
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Llopart Cudié, Xavier, et al.
(författare)
-
Medipix2, a 64k pixel readout chip with 55 μm square elements working in single photon counting mode
- 2002
-
Ingår i: IEEE Transactions on Nuclear Science. - 0018-9499 .- 1558-1578. ; 49, s. 2279-2283
-
Tidskriftsartikel (refereegranskat)abstract
- The Medipix2 chip is a pixel detector readout chip consisting of 256×256 identical elements, each working in single photon counting mode for positive or negative input charge signals. Each pixel cell contains around 500 transistors and occupies a total surface area of 55 μm×55 μm. A 20 μm width octagonal opening connects the detector and the preamplifier input via bump-bonding. The preamplifier feedback provides compensation for detector leakage current on a pixel by pixel basis. Two identical pulse height discriminators are used to create a pulse if the preamplifier output falls within a defined energy window. These digital pulses are then counted with a 13-bit pseudo-random counter. The counter logic, based in a shift register, also behaves as the input/output register for the pixel. Each cell also has an 8-bit configuration register which allows masking, test-enabling and 3-bit individual threshold adjust for each discriminator. The chip can be configured in serial mode and read out either serially or in parallel. The chip is designed and manufactured in a 6-metal 0.25 μm CMOS technology. Preliminary measurements show very good agreement with simulations.
|
|
| 6. |
- Pastorello, A., et al.
(författare)
-
SN 2009E : a faint clone of SN 1987A
- 2012
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 537
-
Tidskriftsartikel (refereegranskat)abstract
- Context. 1987A-like events form a rare sub-group of hydrogen-rich core-collapse supernovae that are thought to originate from the explosion of blue supergiant stars. Although SN 1987A is the best known supernova, very few objects of this group have been discovered and, hence, studied. Aims. In this paper we investigate the properties of SN 2009E, which exploded in a relatively nearby spiral galaxy (NGC 4141) and that is probably the faintest 1987A-like supernova discovered so far. We also attempt to characterize this subgroup of core-collapse supernovae with the help of the literature and present new data for a few additional objects. Methods. The lack of early-time observations from professional telescopes is compensated by frequent follow-up observations performed by a number of amateur astronomers. This allows us to reconstruct a well-sampled light curve for SN 2009E. Spectroscopic observations which started about 2 months after the supernova explosion, highlight significant differences between SN 2009E and the prototypical SN 1987A. Modelling the data of SN 2009E allows us to constrain the explosion parameters and the properties of the progenitor star, and compare the inferred estimates with those available for the similar SNe 1987A and 1998A. Results. The light curve of SN 2009E is less luminous than that of SN 1987A and the other members of this class, and the maximum light curve peak is reached at a slightly later epoch than in SN 1987A. Late-time photometric observations suggest that SN 2009E ejected about 0.04 M-circle dot of Ni-56, which is the smallest Ni-56 mass in our sample of 1987A-like events. Modelling the observations with a radiation hydrodynamics code, we infer for SN 2009E a kinetic plus thermal energy of about 0.6 foe, an initial radius of similar to 7x10(12) cm and an ejected mass of similar to 19 M-circle dot. The photospheric spectra show a number of narrow (v approximate to 1800 km s(-1)) metal lines, with unusually strong Ba II lines. The nebular spectrum displays narrow emission lines of H, Na I, [Ca II] and [O I], with the [O I] feature being relatively strong compared to the [Ca II] doublet. The overall spectroscopic evolution is reminiscent of that of the faint Ni-56-poor type II-plateau supernovae. This suggests that SN 2009E belongs to the low-luminosity, low Ni-56 mass, low-energy tail in the distribution of the 1987A-like objects in the same manner as SN 1997D and similar events represent the faint tail in the distribution of physical properties for normal type II-plateau supernovae.
|
|
| 7. |
- Vismarra, F., et al.
(författare)
-
Isolated Attosecond Pulse Generation Driven by Spatio-Temporal Pulse Reshaping in a Semi-infinite Gas Cell
- 2023
-
Ingår i: 2023 Conference on Lasers and Electro-Optics Europe and European Quantum Electronics Conference, CLEO/Europe-EQEC 2023. - 9798350345995
-
Konferensbidrag (refereegranskat)abstract
- High-order harmonic generation (HHG) is an ubiquitous tool of great interest in many fields of research from imaging to ultrafast spectroscopy [1]. In its most common implementation, an intense (≈ 1014 W/cm2) infrared (IR) pulse is focused on a noble gas target yielding a train of attosecond pulses in the extreme ultraviolet (XUV) spectral region. By adopting proper strategies and target geometries, it is possible to isolate an attosecond pulse out of the train. In this work, we demonstrate the generation of isolated attosecond pulses by spatio-temporal reshaping of few-cycle IR driving pulses in a semi-infinite gas cell. We combine numerical simulations and experiments to investigate the interplay between the spatio-temporal reshaping of the driving field, the generation of harmonics and the isolation of an attosecond pulse.
|
|
