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- Arrizabalaga, O., et al.
(författare)
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High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response
- 2017
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Ingår i: Oncogenesis. - : Springer Science and Business Media LLC. - 2157-9024. ; 6
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Tidskriftsartikel (refereegranskat)abstract
- The elucidation of mechanisms involved in resistance to therapies is essential to improve the survival of patients with malignant gliomas. A major feature possessed by glioma cells that may aid their ability to survive therapy and reconstitute tumors is the capacity for self-renewal. We show here that glioma stem cells (GSCs) express low levels of MKP1, a dual-specificity phosphatase, which acts as a negative inhibitor of JNK, ERK1/2, and p38 MAPK, while induction of high levels of MKP1 expression are associated with differentiation of GSC. Notably, we find that high levels of MKP1 correlate with a subset of glioblastoma patients with better prognosis and overall increased survival. Gain of expression studies demonstrated that elevated MKP1 impairs self-renewal and induces differentiation of GSCs while reducing tumorigenesis in vivo. Moreover, we identified that MKP1 is epigenetically regulated and that it mediates the anti-tumor activity of histone deacetylase inhibitors (HDACIs) alone or in combination with temozolomide. In summary, this study identifies MKP1 as a key modulator of the interplay between GSC self-renewal and differentiation and provides evidence that the activation of MKP1, through epigenetic regulation, might be a novel therapeutic strategy to overcome therapy resistance in glioblastoma.
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- Alvarez-Mon, MA, et al.
(författare)
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Assessment of Antipsychotic Medications on Social Media: Machine Learning Study
- 2021
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Ingår i: Frontiers in psychiatry. - : Frontiers Media SA. - 1664-0640. ; 12, s. 737684-
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Tidskriftsartikel (refereegranskat)abstract
- Background: Antipsychotic medications are the first-line treatment for schizophrenia. However, non-adherence is frequent despite its negative impact on the course of the illness. In response, we aimed to investigate social media posts about antipsychotics to better understand the online environment in this regard.Methods: We collected tweets containing mentions of antipsychotic medications posted between January 1st 2019 and October 31st 2020. The content of each tweet and the characteristics of the users were analyzed as well as the number of retweets and likes generated.Results: Twitter users, especially those identified as patients, showed an interest in antipsychotic medications, mainly focusing on the topics of sexual dysfunction and sedation. Interestingly, paliperidone, despite being among one of the newest antipsychotics, accounted for a low number of tweets and did not generate much interest. Conversely, retweet and like ratios were higher in those tweets asking for or offering help, in those posted by institutions and in those mentioning cognitive complaints. Moreover, health professionals did not have a strong presence in tweet postings, nor did medical institutions. Finally, trivialization was frequently observed.Conclusion: This analysis of tweets about antipsychotic medications provides insights into experiences and opinions related to this treatment. Twitter user perspectives therefore constitute a valuable input that may help to improve clinicians' knowledge of antipsychotic medications and their communication with patients regarding this treatment.
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- Mair, MJ, et al.
(författare)
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Career and Professional Development for Young Oncologists
- 2023
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Ingår i: Oncology research and treatment. - : S. Karger AG. - 2296-5262 .- 2296-5270. ; 46:3, s. 67-70
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Tidskriftsartikel (refereegranskat)abstract
- Young oncologists around the globe face many challenges when it comes to their career and professional development. Aspects such as time management, work-life balance, career progression, and educational opportunities are only some of them. Professional societies have identified these challenges in this professional group and designed programs to tackle them specifically. The importance of this strategy cannot be overstated, as young oncologists, defined by most societies as oncologists under 40 years of age, compose almost 50% of the oncology workforce. On the other hand, recent surveys have shown that many young oncologists are considering alternative career paths due to burnout issues aggravated by the COVID-19 pandemic, on top of all other challenges. The virtual setting that has been forcedly introduced into our professional life has shortened distances between professionals and might have contributed to more accessible access to information and opportunities that some young oncologists could not profit from due to their traveling constraints. On the other hand, this virtual setting has shown us the asymmetries in opportunities for these professionals. Knowledgeable of all this, we summarize in this article some of the career and professional development offers available to all young oncologists, which we consider could help them deal with current and future challenges.
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- Bayona, Jhon F., et al.
(författare)
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A High Efficiency Fluorescent Lamp Electronic Ballast Design
- 2016
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Ingår i: IEEE CACIDI 2016 - IEEE Conference on Computer Sciences. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781509029389
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Konferensbidrag (refereegranskat)abstract
- This paper presents the design and implementation of an electronic ballast for powering a fluorescent lamp. The purpose of this work is to improve the efficiency of the ballast by implementing a Series Resonant Inverter (SRI) in half-bridge configuration instead classic Series-Parallel Resonant (SPRI); in order to allow to provide the voltage steady state of the lamp. By other hand, this DC-AC converter will supply the voltage lamp ignition. Results on the proposed experimental prototype, using a fluorescent lamp of 32W, shows a better efficiency compared to traditional SPRI configurations.
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- Bayona, Jhon F., et al.
(författare)
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Linear Control of a Power Factor Correction Rectifier in Half-bridge Configuration
- 2016
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Ingår i: IEEE CACIDI 2016 - IEEE CONFERENCE ON COMPUTER SCIENCES. - : IEEE. - 9781509029389
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Konferensbidrag (refereegranskat)abstract
- This paper presents a detailed analysis of a single phase high power factor boost half-bridge rectifier (RPFU-HBB). The purpose of this work is to achieve a unity power factor with tight-regulated output voltage. Using the experimental prototype for 120 Vrms input voltage, output power 80W and output voltage of 450V; a power factor of 0.99 and total harmonic distortion of 2.5% was obtained. In order to eliminate the unbalance voltage of the two output capacitors a special control scheme was developed. Modeling, theoretical linearization around the operating point of the RPFU-HBB, design considerations of the current controller output voltage by means of average current method and experimental work tested through simulation model RPFU-HBB are presented.
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