| 1. |
- Berglund, Lars, et al.
(author)
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Profession, forskning och praktik : 30 rektorers syn på specialpedagogisk professionalitet
- 2007
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In: Educare. - : Malmö högskola, Lärarutbildningen. - 1653-1868 .- 2004-5190. ; :2, s. 39-51
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Journal article (peer-reviewed)abstract
- This article is a synthesis of four investigations made by students at the special educational program at Malmö University. It describes how headmasters experience the professional role of the special needs pedagogue in schools. Research questions concerning the relationship between higher education and school practice are elucidated in the article. The responses are analyzed and problematized with the help of von Wright’s Action theory as well as of Dahllöf’s frame factor theory. In the interviews headmasters describe the special educational activities and the special pedagogue profession as multifaceted and complex. This is a situation which impedes good functioning and effective use of competence resources. Moreover, headmasters are frequently caught between the visions of policy instruments and school practice, not least concerning situational acting, and the question of short or long term planning and acting.
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| 2. |
- Braekeveldt, Noémie, et al.
(author)
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Neuroblastoma patient-derived orthotopic xenografts reflect the microenvironmental hallmarks of aggressive patient tumours
- 2016
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In: Cancer Letters. - : Elsevier BV. - 1872-7980 .- 0304-3835. ; 375:2, s. 384-389
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Journal article (peer-reviewed)abstract
- Treatment of high-risk childhood neuroblastoma is a clinical challenge hampered by a lack of reliable neuroblastoma mouse models for preclinical drug testing. We have previously established invasive and metastasising patient-derived orthotopic xenografts (PDXs) from high-risk neuroblastomas that retained the genotypes and phenotypes of patient tumours. Given the important role of the tumour microenvironment in tumour progression, metastasis, and treatment responses, here we analysed the tumour microenvironment of five neuroblastoma PDXs in detail. The PDXs resembled their parent tumours and retained important stromal hallmarks of aggressive lesions including rich blood and lymphatic vascularisation, pericyte coverage, high numbers of cancer-associated fibroblasts, tumour-associated macrophages, and extracellular matrix components. Patient-derived tumour endothelial cells occasionally formed blood vessels in PDXs; however, tumour stroma was, overall, of murine origin. Lymphoid cells and lymphatic endothelial cells were found in athymic nude mice but not in NSG mice; thus, the choice of mouse strain dictates tumour microenvironmental components. The murine tumour microenvironment of orthotopic neuroblastoma PDXs reflects important hallmarks of aggressive and metastatic clinical neuroblastomas. Neuroblastoma PDXs are clinically relevant models for preclinical drug testing.
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| 3. |
- Sandén, Gustav, et al.
(author)
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Defunctioning stoma before neoadjuvant treatment or resection of endoscopically obstructing rectal cancer
- 2023
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In: International Journal of Colorectal Disease. - : Springer Nature. - 0179-1958 .- 1432-1262. ; 38:1
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Journal article (peer-reviewed)abstract
- Aim: To investigate whether patients with endoscopically untraversable rectal cancer may benefit from a defunctioning stoma created before neoadjuvant therapy or resectional surgery.Methods: This retrospective study comprise patients diagnosed with rectal cancer during 2007–2020 in Region Västerbotten, Sweden. The primary outcome was time between diagnosis and any treatment, while survival and the incidence of complications were secondary outcomes. Excluded were patients without endoscopic obstruction, patients already having a stoma, patients with recurrent disease, palliative patients, and patients receiving a stoma shortly after diagnosis due to any urgent bowel-related complication. Data were obtained from the Swedish Colorectal Cancer Registry and medical records. Kaplan–Meier failure curves were drawn, and a multivariable Cox regression model was employed for confounding adjustment.Results: Out of 843 patients, 57 remained after applying exclusion criteria. Some 12/57 (21%) patients received a planned stoma before treatment, and the remainder received upfront neoadjuvant therapy or surgery. Median time to any treatment was 51 days for the planned stoma group and 36 days for the control group, with an adjusted hazard ratio of 0.28 (95% confidence interval: 0.12–0.64). Complications occurred at a rate of 5/12 (42%) and 7/45 (16%) in the planned stoma group and control group, respectively. Survival was similar between groups.Conclusion: A planned stoma results in treatment delay, but it remains unclear whether this is clinically relevant. Complications were more common in the planned stoma group, although the data are limited. While larger studies are needed, it seems feasible to avoid defunctioning stomas even in endoscopically obstructing rectal cancers.
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| 4. |
- Sandén, Ingrid
(author)
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Lek, hälsa och lärande : Om lek som specialpedagogisk metod
- 2005
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Reports (other academic/artistic)abstract
- Baksidestext: Hur ser lekpedagoger på sitt eget arbete? I denna rapport utfrågas bl.a. 248 lekpedagoger om lekens betydelse för barn. Har leken betydelse för barns intellektuella, känslomässiga och sociala utveckling? Varför är lekarbete en framgångsrik metod för barn/elever i behov av särskilt stöd? Hur mycket stöd och handledning får de utbildade lekpedagogerna? Hur mycket samverkar de med föräldrar och utbildningsledare? Det är några frågor som tas upp i denna rapport om lekarbetets betydelse.
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| 5. |
- Sandén, Ingrid
(author)
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Skoldaghem: Ett alternativ för elever i behov av särskilt stöd
- 2000
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Doctoral thesis (other academic/artistic)abstract
- This thesis concerns ten pupils in need of special support. The overriding principle governing the Swedish educational system today is that pupils with functional difficulties should be integrated into ordinary schools, but exceptions may be made and the pupils can attend a special day-school. The primary aim of the present thesis is to study the progress of seven students, attending special day-schools with regard to · sense of self · sense of competence · social skill in work, play and other interaction. A secondary aim is to look at what factors in the special day-school environment contribute to the pupils’ progress. A third is to study what happens to these pupils when they return to their local school environment. I also describe the progress of three children in need of special support, who remain at their ordinary schools. Interviews were the main method of data collection. Pupils, parents and teachers were interviewed, so informant triangulation was established. A rating scale was also used, thus achieving methodological triangulation. The result shows that during their attendance at special day-schools all the pupils developed a more positive sense of self and competence and increased their social skill in work, play and other interaction. For most of the pupils the positive progress remained after their return to their local schools, but to a lower degree. The school environment to which the pupils first became accustomed was described by the teachers working there as often having a lively classroom situation, with teachers who lacked both special education competence, resources, and time for children in need of special support. The environment provided by the special day-school, however, with many adults present, who had time for the children, made the special support possible. In the special day-school, where the pedagogical work had its starting point in each pupil’s needs and skill, a positive relation was established between the sense of self, sense of competence and social skill. The constantly present, competent and involved adults, the small groups of pupils, the integrated school day and the close co-operation with parents all contributed to a positive development for a majority of the pupils. This positive trend was broken however, in two cases on return to the local school, where pupil groups were large and sometimes multi-graded, and where teachers lacked time and special education competence demanded by pupils in need of special support. What my study most convincingly shows is that the ordinary school can not always give pupils with emotional disturbances and behavioural disorders the sufficient special support they need to develop their sense of self, sense of competence and social skill. In a special day-school these pupils can get the special support they need.
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| 6. |
- Sehic, Daniel, et al.
(author)
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Absence of Epstein-Barr and Cytomegalovirus Infection in Neuroblastoma Cells by Standard Detection Methodologies.
- 2013
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In: Pediatric Blood & Cancer. - : Wiley. - 1545-5017 .- 1545-5009. ; 60:9, s. 91-93
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Journal article (peer-reviewed)abstract
- Indications exist in the scientific literature that infection with human herpes family viruses may contribute to the pathogenesis of neuroblastoma (NB). However, systematic investigations regarding viral presence in NB cells have been scarcely reported. Here, the presence of DNA from Epstein-Barr virus (EBV) and human cytomegalovirus (HCMV) was assessed by PCR in 12 NBs, supplemented with RNA in situ hybridization, immunohistochemical detection, and high-throughput DNA sequencing. These standard methods did not detect infection by EBV or HCMV in NB cells in any tumor, while occasional immune cells were positive for EBV RNA or HCMV protein in four cases. Pediatr Blood Cancer © 2013 Wiley Periodicals, Inc.
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