| 1. |
- Gaff, Milan, et al.
(författare)
-
The effect of chemical changes during thermal modification of European oak and Norway spruce on elasticity properties
- 2019
-
Ingår i: Composite structures. - : Elsevier. - 0263-8223 .- 1879-1085. ; 220, s. 529-538
-
Tidskriftsartikel (refereegranskat)abstract
- The elasticity in bending of European oak (Quercus robur L.) and Norway spruce (Picea abies (L.) Karst.) timber was evaluated before and after thermal modificationand related to the changes in chemical composition of the wood as a result of the modification. A new software was developed (MATESS) and used to identify characteristic points on the force-deformation diagram. The modulus of elasticity(MOE), stress at the limit of proportionality (LOP) and elastic potential (PE) were used to describe the wood properties. Extractives, lignin, cellulose, holocellulose, and hemicelluloses were analysed to reveal the patterns that occur during the loading of the specimens. Thermal modification lowers the mechanical properties (MOE, LOP and PE) of oak and spruce wood, and the reduction increases with increasing modification temperature. Changes in chemical composition of thermally modified wood show a strong relationship to the reduction in elasticity properties for bot species.
|
|
| 2. |
|
|
| 3. |
- Lindskog, Bengt I., et al.
(författare)
-
Medicinsk terminologi
- 2004
-
Bok (övrigt vetenskapligt/konstnärligt)
|
|
| 4. |
- Lysiak, Malgorzata, et al.
(författare)
-
Deletions on Chromosome Y and Downregulation of the SRY Gene in Tumor Tissue Are Associated with Worse Survival of Glioblastoma Patients
- 2021
-
Ingår i: Cancers. - : MDPI. - 2072-6694. ; 13:7
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Biological causes of sex disparity seen in the prevalence of cancer, including glioblastoma (GBM), remain poorly understood. One of the considered aspects is the involvement of the sex chromosomes, especially loss of chromosome Y (LOY).METHODS: Tumors from 105 isocitrate dehydrogenase (IDH) wild type male GBM patients were tested with droplet digital PCR for copy number changes of ten genes on chromosome Y. Decreased gene expression, a proxy of gene loss, was then analyzed in 225 IDH wild type GBM derived from TCGA and overall survival in both cohorts was tested with Kaplan-Meier log-rank analysis and maximally selected rank statistics for cut-off determination.RESULTS: LOY was associated with significantly shorter overall survival (7 vs. 14.6 months, p = 0.0016), and among investigated individual genes survival correlated most prominently with loss of the sex-determining region Y gene (SRY) (10.8 vs. 14.8 months, p = 0.0031). Gene set enrichment analysis revealed that epidermal growth factor receptor, platelet-derived growth factor receptor, and MYC proto-oncogene signaling pathways are associated with low SRY expression.CONCLUSION: Our data show that deletions and reduced gene expression of chromosome Y genes, especially SRY, are associated with reduced survival of male GBM patients and connected to major susceptibility pathways of gliomagenesis.
|
|
| 5. |
- Moberg, Christina, et al.
(författare)
-
De unga gör helt rätt när de stämmer staten
- 2022
-
Ingår i: Aftonbladet. - 1103-9000.
-
Tidskriftsartikel (populärvet., debatt m.m.)abstract
- 1 620 forskare och lärare i forskarvärlden: Vi ställer oss bakom Auroras klimatkrav
|
|
| 6. |
- Rademacher, Peter, et al.
(författare)
-
European co-operation in wood research From native wood to engineered materials : Part 3: engineered hybrid wood-based products
- 2017
-
Ingår i: Pro Ligno. - Romania : Pro Ligno Foundation. - 1841-4737 .- 2069-7430. ; 13:4, s. 361-372
-
Tidskriftsartikel (refereegranskat)abstract
- Forest-based industries have been continuously developing advanced processes, materials and wood-based solutions, to meet evolving demands and increase competitiveness. Engineered wood products (EWPs) constitute one emerging group of materials aiming at improved property profiles of wood, and provide desired shapes and functionality. In this paper, the main principles for different processes to soften wood and make it more flexible for bending and moulding, such as longitudinal compression, plasticization by water vapour and gaseous ammonia, and a dielectric heating technique, are discussed. Examples of implementation of these techniques for the production of wooden products are presented, and the use of reed canary grass, and a novel technique for embossment of hybrid particleboards are also further discussed.
|
|
| 7. |
|
|
| 8. |
- Sandberg, Ulf, 1946-, et al.
(författare)
-
Rolling resistance : basic information and state-of-the-art on measurement methods. Final version
- 2011
-
Rapport (övrigt vetenskapligt/konstnärligt)abstract
- MIRIAM has established a sub-project (SP), designated SP 1, to deal with measurement methods for rolling resistance and related issues. This subject forms the most fundamental basis for the MIRIAM ambition to consider rolling resistance in pavement management or other types of infrastructure systems. Without robust measurement methods and equipment that can use them there will be no reliable data as input to such systems and the end result will be most uncertain, if useful at all.In order to develop and study measurement methods, there must be a basic understanding of the influencing parameters as well as what energy losses that should be included in the concept of rolling resistance. These issues are, therefore, important parts of the work in SP 1.This report is intended to provide basic knowledge about the part of the tyre and road interaction which relates to rolling resistance; for example, the mechanisms that create rolling resistance, and the influence on rolling resistance of various tyre and road parameters. The intention is also to suggest a definition of rolling resistance for the purposes of this project, as well as to provide some detailed state-of-the-art knowledge about the measurement methods and equipment that are useful for collecting rolling resistance data.
|
|
| 9. |
- Woll, Petter S, et al.
(författare)
-
Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo.
- 2014
-
Ingår i: Cancer Cell. - : Elsevier BV. - 1878-3686 .- 1535-6108. ; 25:6, s. 794-808
-
Tidskriftsartikel (refereegranskat)abstract
- Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which different cancer cells contribute to propagating malignancies in patients remains unexplored. In low- to intermediate-risk myelodysplastic syndromes (MDS), we establish the existence of rare multipotent MDS stem cells (MDS-SCs), and their hierarchical relationship to lineage-restricted MDS progenitors. All identified somatically acquired genetic lesions were backtracked to distinct MDS-SCs, establishing their distinct MDS-propagating function in vivo. In isolated del(5q)-MDS, acquisition of del(5q) preceded diverse recurrent driver mutations. Sequential analysis in del(5q)-MDS revealed genetic evolution in MDS-SCs and MDS-progenitors prior to leukemic transformation. These findings provide definitive evidence for rare human MDS-SCs in vivo, with extensive implications for the targeting of the cells required and sufficient for MDS-propagation.
|
|
| 10. |
- Zhang, Jun, et al.
(författare)
-
Detection and Imaging of A beta 1-42 and Tau Fibrils by Redesigned Fluorescent X-34 Analogues
- 2018
-
Ingår i: Chemistry - A European Journal. - : WILEY-V C H VERLAG GMBH. - 0947-6539 .- 1521-3765. ; 24:28, s. 7210-7216
-
Tidskriftsartikel (refereegranskat)abstract
- We revisited the Congo red analogue 2,5-bis(4-hydroxy-3-carboxy-styryl)benzene (X-34) to develop this highly fluorescent amyloid dye for imaging Alzheimers disease (AD) pathology comprising A beta and Tau fibrils. A selection of ligands with distinct optical properties were synthesized by replacing the central benzene unit of X-34, with other heterocyclic moieties. Full photophysical characterization was performed, including recording absorbance and fluorescence spectra, Stokes shift, quantum yield and fluorescence lifetimes. All ligands displayed high affinity towards recombinant amyloid fibrils of A beta 1-42 (13-300nmK(d)) and Tau (16-200nmK(d)) as well as selectivity towards the corresponding disease-associated protein aggregates in AD tissue. We observed that these ligands efficiently displaced X-34, but not Pittsburgh compound B (PiB) from recombinant A beta 1-42 amyloid fibrils, arguing for retained targeting of the Congo red type binding site. We foresee that the X-34 scaffold offers the possibility to develop novel high-affinity ligands for A pathology found in human AD brain in a different mode compared with PiB, potentially recognizing different polymorphs of A fibrils.
|
|
