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Träfflista för sökning "WFRF:(Sandgren P.) "

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1.	Forsberg, Lars A., et al. (författare) Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer 2014 Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 46:6, s. 624-628 Tidskriftsartikel (refereegranskat)abstract Incidence and mortality for sex-unspecific cancers are higher among men, a fact that is largely unexplained(1,2). Furthermore, age-related loss of chromosome Y (LOY) is frequent in normal hematopoietic cells(3,4), but the phenotypic consequences of LOY have been elusive(5-10). From analysis of 1,153 elderly men, we report that LOY in peripheral blood was associated with risks of all-cause mortality (hazards ratio (HR) = 1.91, 95% confidence interval (CI) = 1.17-3.13; 637 events) and non-hematological cancer mortality (HR = 3.62, 95% CI = 1.56-8.41; 132 events). LOY affected at least 8.2% of the subjects in this cohort, and median survival times among men with LOY were 5.5 years shorter. Association of LOY with risk of all-cause mortality was validated in an independent cohort (HR = 3.66) in which 20.5% of subjects showed LOY. These results illustrate the impact of post-zygotic mosaicism on disease risk, could explain why males are more frequently affected by cancer and suggest that chromosome Y is important in processes beyond sex determination. LOY in blood could become a predictive biomarker of male carcinogenesis.
2.	van der Meer, PF, et al. (författare) Aggregates in platelet concentrates 2015 Ingår i: Vox sanguinis. - : Wiley. - 1423-0410 .- 0042-9007. ; 108:1, s. 96-125 Tidskriftsartikel (refereegranskat)
3.	Meinke, S, et al. (författare) Cryopreservation of buffy coat-derived platelet concentrates photochemically treated with amotosalen and UVA light 2018 Ingår i: Transfusion. - : Wiley. - 1537-2995 .- 0041-1132. ; 58:11, s. 2657-2668 Tidskriftsartikel (refereegranskat)
4.	Meinke, S, et al. (författare) Platelets made HLA deficient by acid treatment aggregate normally and escape destruction by complement and phagocytes in the presence of HLA antibodies 2016 Ingår i: Transfusion. - : Wiley. - 1537-2995 .- 0041-1132. ; 56:2, s. 370-382 Tidskriftsartikel (refereegranskat)
5.	Mirlashari, MR, et al. (författare) HLA class I depletion by citric acid, and irradiation of apheresis platelets for transfusion of refractory patients 2021 Ingår i: Transfusion. - : Wiley. - 1537-2995 .- 0041-1132. ; 61:4, s. 1222-1234 Tidskriftsartikel (refereegranskat)
6.	Nystedt, B., et al. (författare) Sarek : A portable workflow for whole-genome sequencing analysis of germline and somatic variants 2020 Ingår i: F1000 Research. - : F1000 Research Ltd. - 2046-1402. ; 9 Tidskriftsartikel (refereegranskat)abstract Whole-genome sequencing (WGS) is a fundamental technology for research to advance precision medicine, but the limited availability of portable and user-friendly workflows for WGS analyses poses a major challenge for many research groups and hampers scientific progress. Here we present Sarek, an open-source workflow to detect germline variants and somatic mutations based on sequencing data from WGS, whole-exome sequencing (WES), or gene panels. Sarek features (i) easy installation, (ii) robust portability across different computer environments, (iii) comprehensive documentation, (iv) transparent and easy-to-read code, and (v) extensive quality metrics reporting. Sarek is implemented in the Nextflow workflow language and supports both Docker and Singularity containers as well as Conda environments, making it ideal for easy deployment on any POSIX-compatible computers and cloud compute environments. Sarek follows the GATK best-practice recommendations for read alignment and pre-processing, and includes a wide range of software for the identification and annotation of germline and somatic single-nucleotide variants, insertion and deletion variants, structural variants, tumour sample purity, and variations in ploidy and copy number. Sarek offers easy, efficient, and reproducible WGS analyses, and can readily be used both as a production workflow at sequencing facilities and as a powerful stand-alone tool for individual research groups. The Sarek source code, documentation and installation instructions are freely available at https://github.com/nf-core/sarek and at https://nf-co.re/sarek/.
7.	Sandgren, P, et al. (författare) Random aggregates in newly produced platelet units are associated with platelet activation and release of the immunomodulatory factors sCD40L and RANTES 2014 Ingår i: Transfusion. - : Wiley. - 1537-2995 .- 0041-1132. ; 54:3, s. 602-612 Tidskriftsartikel (refereegranskat)
8.	Sandgren, P, et al. (författare) The effects of pneumatic tube transport on fresh and stored platelets in additive solution 2014 Ingår i: Blood transfusion = Trasfusione del sangue. - 2385-2070. ; 12:1, s. 85-90 Tidskriftsartikel (refereegranskat)
9.	Schmied, L., et al. (författare) Antibody-dependent natural killer cell cytotoxicity : A potential mechanism of platelet lysis in immune thrombocytopenia 2021 Ingår i: Scandinavian Journal of Immunology. - : WILEY. - 0300-9475 .- 1365-3083. ; 94:6 Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
10.	Tesi, B, et al. (författare) Diagnostic yield and short-term clinical implications of nationwide germline whole genome sequencing in 280 children with solid tumors 2024 Ingår i: EUROPEAN JOURNAL OF HUMAN GENETICS. - 1018-4813. ; 32, s. 52-52 Konferensbidrag (övrigt vetenskapligt/konstnärligt)

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Typ av publikation: tidskriftsartikel (67); konferensbidrag (16); bokkapitel (3); annan publikation (1)

Typ av innehåll: refereegranskat (61); övrigt vetenskapligt/konstnärligt (26)

Författare/redaktör: Sandgren, P (50); Sjodin, A. (10); Dumanski, Jan P (10); Sandgren, Johanna (10); Larsson, S. (8); Menzel, Uwe (8); visa fler...; Komorowski, Jan (8); Andersson, Robin (8); Uhlin, M. (7); Wikman, A (7); Hoglund, P (7); Piotrowski, Arkadius ... (7); de Ståhl, Teresita D ... (7); Vesterinen, M. (6); Sandgren, A (6); Bruder, Carl E G (6); Meinke, S (6); Nord, Helena (5); Larsson, L (4); Golovleva, Irina (4); Hansson, M (3); Ohlsson, S (3); Westermark, P (3); Verheggen, C (3); Sandgren, O (3); Larsson, Lars (2); Lange, C. (2); Svensson, L (2); Hultenby, K (2); Menzies, D (2); Abubakar, I (2); Matteelli, A (2); Nister, M (2); Strang, P (2); Wernerman, J (2); Jansson, B (2); Sandgren, Anna, 1970 ... (2); De Stahl, TD (2); Åkerström, Göran (2); Westin, Gunnar (2); Allison, David B (2); Sletten, K (2); Köhn, Linda, 1979- (2); GRILLNER, P (2); MCNURLAN, MA (2); ESSEN, P (2); GARLICK, PJ (2); Barnekow, L (2); Rangaka, MX (2); Wilkinson, RJ (2); visa färre...

Lärosäte: Karolinska Institutet (63); Uppsala universitet (18); Umeå universitet (4); Lunds universitet (4); Kungliga Tekniska Högskolan (2); Linköpings universitet (2); visa fler...; Linnéuniversitetet (2); Göteborgs universitet (1); Södertörns högskola (1); Chalmers tekniska högskola (1); IVL Svenska Miljöinstitutet (1); visa färre...

Språk: Engelska (87)

Forskningsämne (UKÄ/SCB): Medicin och hälsovetenskap (8); Naturvetenskap (7); Teknik (2); Humaniora (2); Lantbruksvetenskap (1)

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