| 1. |
- Henningsson, Susanne, 1977, et al.
(författare)
-
A missense polymorphism in the putative pheromone receptor gene VN1R1 is associated with sociosexual behavior
- 2017
-
Ingår i: Translational Psychiatry. - : Springer Science and Business Media LLC. - 2158-3188. ; 7
-
Tidskriftsartikel (refereegranskat)abstract
- Pheromones regulate social and reproductive behavior in most mammalian species. These effects are mediated by the vomeronasal and main olfactory systems. Effects of putative pheromones on human neuroendocrine activity, brain activity and attractiveness ratings suggest that humans may communicate via similar chemosignaling. Here we studied two samples of younger and older individuals, respectively, with respect to one nonsynonymous polymorphism in the gene encoding the human vomeronasal type-1 receptor 1, VN1R1, and one nonsynonymous polymorphism in the gene encoding the olfactory receptor OR7D4. Participants in both samples had self-reported their sociosexual behavior using the sociosexual orientation inventory, including questions regarding lifetime number of one-night stands, number of partners last year and expected number of partners the coming 5 years. In women, there was a significant association between the VN1R1 polymorphism and sociosexual behavior in both samples, driven specifically by the question regarding one-night stands. Our results support the hypothesis that human social interaction is modulated by communication via chemosignaling.
|
|
| 2. |
- Baur, E., et al.
(författare)
-
Paraphilic Sexual Interests and Sexually Coercive Behavior: A Population-Based Twin Study
- 2016
-
Ingår i: Archives of Sexual Behavior. - : Springer Science and Business Media LLC. - 0004-0002 .- 1573-2800. ; 45:5, s. 1163-1172
-
Tidskriftsartikel (refereegranskat)abstract
- Prior research with selected clinical and forensic samples suggests associations between paraphilic sexual interests (e.g., exhibitionism and sexual sadism) and sexually coercive behavior. However, no study to date used a large, representative and genetically informative population sample to address the potential causal nature of this association. We used self-report data on paraphilic and sexually coercive behavior from 5990 18- to 32-year-old male and female twins from a contemporary Finnish population cohort. Logistic regression and co-twin control models were employed to examine if paraphilic behaviors were causally related to coercive behavior or if suggested links were confounded by familial (genetic or common family environment) risk factors. Results indicated that associations between four out of five tested paraphilic behaviors (exhibitionism, masochism, sadism, and voyeurism, respectively) and sexually coercive behavior were moderate to strong. Transvestic fetishism was not independently associated with sexual coercion. Comparisons of twins reporting paraphilic behavior with their paraphilic behavior-discordant twin further suggested that associations were largely independent of shared genetic and environmental confounds, consistent with a causal association. In conclusion, similar to previously reported predictive effects of paraphilias on sexual crime recidivism, paraphilic behavior among young adults in the general population increases sexual offending risk. Further, early identification of paraphilic interest and preventive interventions with at-risk individuals might also reduce perpetration of first-time sexual violence.
|
|
| 3. |
|
|
| 4. |
- Jern, Patrick, et al.
(författare)
-
Are single nucleotide polymorphisms in the oxytocin and vasopressin 1A/1B receptor genes likely candidates for variation in ejaculatory function?
- 2012
-
Ingår i: Bju International. - 1464-4096. ; 110:11C
-
Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES To investigate associations between single nucleotide polymorphisms (SNPs) linked to the oxytocin, To investigate these associations in a large, population-based sample. PATIENTS AND METHODS In all, 1517 male twins and non-twin brothers of twins aged 18-45 years (mean = 26.43; SD = 4.87) A Bayesian linear mixed-effects model, which appropriately controls for between subjects dependence, We corrected for multiple testing using a linkage disequilibrium correlation measure. RESULTS We found a heterozygote effect on one SNP in the oxytocin receptor gene (rs75775), so that individuals Several SNPs in the arginine vasopressin receptor genes had rare or very rare genotypes. This study CONCLUSIONS Our results regarding the oxytocin receptor polymorphisms support previous studies that indicate a Oxytocin receptor genes are, for example, unlikely suitable targets for pharmacogenetic intervention Rare variants in arginine vasopressin receptor genes may have significant effects on premature
|
|
| 5. |
- Johansson, A, et al.
(författare)
-
Alcohol and aggressive behavior in men-moderating effects of oxytocin receptor gene (OXTR) polymorphisms.
- 2012
-
Ingår i: Genes, brain, and behavior. - 1601-183X. ; 11:2, s. 214-221
-
Tidskriftsartikel (refereegranskat)abstract
- We explored if the disposition to react with aggression while alcohol intoxicated was moderated by polymorphic variants of the oxytocin receptor gene (OXTR). Twelve OXTR polymorphisms were genotyped in 116 Finnish men [aged 18-30, M = 22.7, standard deviation (SD) = 2.4] who were randomly assigned to an alcohol condition in which they received an alcohol dose of 0.7 g pure ethanol/kg body weight or a placebo condition. Aggressive behavior was measured using a laboratory paradigm in which it was operationalized as the level of aversive noise administered to a fictive opponent. No main effects of the polymorphisms on aggressive behavior were found after controlling for multiple testing. The interactive effects between alcohol and two of the OXTR polymorphisms (rs4564970 and rs1488467) on aggressive behavior were nominally significant and remained significant for the rs4564970 when controlled for multiple tests. To the best of our knowledge, this is the first experimental study suggesting interactive effects of specific genetic variants and alcohol on aggressive behavior in humans.
|
|
| 6. |
- Johansson, A., et al.
(författare)
-
Associations between oxytocin receptor gene (OXTR) polymorphisms and self-reported aggressive behavior and anger: Interactions with alcohol consumption
- 2012
-
Ingår i: Psychoneuroendocrinology. - : Elsevier BV. - 0306-4530. ; 37:9, s. 1546-1556
-
Tidskriftsartikel (refereegranskat)abstract
- Oxytocin has been implicated in the regulation of social as well as aggressive behaviors, and in a recent study we found that the effect of alcohol on aggressive behavior was moderated by the individual's genotype on an oxytocin receptor gene (OXTR) polymorphism (Johansson et al., 2012). In this study we wanted to deepen and expand the analysis by exploring associations between three (rs1488467, rs4564970, rs1042778) OXTR polymorphisms and aggressive behavior, trait anger as well as anger control in a population-based sample of Finnish men and women (N = 3577) aged between 18 and 49 years (M = 26.45 years, SD = 5.02). A specific aim was to investigate if the polymorphisms would show interactive effects with alcohol consumption on aggressive behavior and trait anger, as well as to explore whether these polymorphisms affect differences in anger control between self-reported sober and intoxicated states. The results showed no main effects of the polymorphisms, however, three interactions between the polymorphisms and alcohol consumption were found. The effect of alcohol consumption on aggressive behavior was moderated by the genotype of the individual on the rs4564970 polymorphism, in line with previous results (Johansson et al., 2012). For trait anger, both the rs1488467 and the rs4564970 polymorphisms interacted with alcohol consumption. It appears that the region of the OXTR gene including both the rs4564970 and the rs1488467 polymorphisms may be involved in the regulation of the relationship between alcohol and aggressive behavior as well as between alcohol and the propensity to react to situations with elevated levels of anger. (C) 2012 Elsevier Ltd. All rights reserved.
|
|
| 7. |
- Johansson, A., et al.
(författare)
-
The Genetics of Sexuality and Aggression (GSA) Twin Samples in Finland
- 2013
-
Ingår i: Twin Research and Human Genetics. - : Cambridge University Press (CUP). - 1832-4274 .- 1839-2628. ; 16:1, s. 150-156
-
Tidskriftsartikel (refereegranskat)abstract
- The Genetics of Sexuality and Aggression (GSA) project was launched at the Abo Akademi University in Turku, Finland in 2005 and has so far undertaken two major population-based data collections involving twins and siblings of twins. To date, it consists of about 14,000 individuals (including 1,147 informative monozygotic twin pairs, 1,042 informative same-sex dizygotic twin pairs, 741 informative opposite-sex dizygotic twin pairs). Participants have been recruited through the Central Population Registry of Finland and were 18–49 years of age at the time of the data collections. Saliva samples for DNA genotyping (n = 4,278) and testosterone analyses (n = 1,168) were collected in 2006. The primary focus of the data collections has been on sexuality (both sexual functioning and sexual behavior) and aggressive behavior. This paper provides an overview of the data collections as well as an outline of the phenotypes and biological data assembled within the project. A detailed overview of publications can be found at the project's Web site: http://www.cebg.fi/.
|
|
| 8. |
- Rehan, W., et al.
(författare)
-
Effects of MAOA genotype and childhood experiences of physical and emotional abuse on aggressive behavior in adulthood
- 2015
-
Ingår i: Nordic Psychology. - : Informa UK Limited. - 1901-2276 .- 1904-0016. ; 67:4, s. 301-312
-
Tidskriftsartikel (refereegranskat)abstract
- A functional polymorphism in the monoamine oxidase A (MAOA) gene located on the X chromosome (Xp11.23-11.4) has earned the nickname warrior gene because of its association with antisocial behavior and delinquency. Previous findings on adults and adolescents have found some evidence that the MAOA gene moderates the impact of childhood abuse experiences on the risk of developing aggressive behavior. Thus far, however, attempts to replicate these findings have been mixed. The aims of the present study were to investigate whether the MAOA polymorphism affects aggressive behavior alone and in combination with childhood abuse experiences. We tried to replicate this using a sample of 1447 male and 2179 female Finnish twins and their siblings. In the present study, the Childhood Trauma Questionnaire and Aggression Questionnaire were used. There was a positive correlation between childhood abuse experiences and later aggressive behavior in adolescence or adulthood both for men and women. The results showed the effects of the 4-repeat allele of MAOA promoter polymorphism on physical aggressive behavior for women. It seems that there is an interaction between the 3-repeat allele of MAOA promoter polymorphism and emotional abuse experiences on aggressive behavior for women. In conclusions, this study, using a large population-based sample, found partial support for an interaction between MAOA genotype and childhood abuse experiences on aggressive behavior.
|
|
| 9. |
- Rehan, W., et al.
(författare)
-
Gene-Environment Correlation Between the Dopamine Transporter Gene (DAT1) Polymorphism and Childhood Experiences of Abuse
- 2018
-
Ingår i: Journal of Interpersonal Violence. - : SAGE Publications. - 0886-2605 .- 1552-6518. ; 33:13, s. 2059-2072
-
Tidskriftsartikel (refereegranskat)abstract
- In the present study, we investigated the possible gene-environment correlation between the dopamine transporter gene (DAT1) polymorphism and childhood experiences of abuse and neglect. Genetic information was obtained from 1,442 male and 2,178 female twins and their siblings drawn from a Finnish population-based sample. The Childhood Trauma Questionnaire was used to measure the childhood experiences of abuse and neglect. In men, the DAT1 polymorphism was associated with having experienced sexual abuse in childhood, such that men with the 9R9R genotype reported less sexual abuse experiences than men with the 9R10R or the 10R10R genotypes. In women, there was an association between the DAT1 polymorphism and childhood experiences of emotional abuse, such that women with the 9R9R genotype reported less emotional abuse experiences than women with the 9R10R or 10R10R genotypes. No other associations between the DAT1 polymorphism and childhood experiences of abuse and neglect were found. In sum, the results suggested that some genetic components might predispose children to experience childhood abuse and neglect. Possible reasons for this association were discussed.
|
|
| 10. |
- Sandnabba, K.N., et al.
(författare)
-
Sexuella komponenter bakom brott. : Sexual components behind crime
- 2008
-
Ingår i: Handbok i Rättspsykologi. - Stockholm : Liber. ; , s. 175-199
-
Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Kapitlet uppmärksammar teorier om sexualitet, sexuella komponenter bakom brott, sexuella fantasier, sexuella varianter, samt psykologisk obduktion.
|
|
