| 1. |
- Gunst, Annika, et al.
(författare)
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A study of possible associations between single nucleotide polymorphisms in the estrogen receptor 2 gene and female sexual desire.
- 2015
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Ingår i: The journal of sexual medicine. - : Oxford University Press (OUP). - 1743-6109 .- 1743-6095. ; 12:3, s. 676-84
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Tidskriftsartikel (refereegranskat)abstract
- Female sexual desire and arousal problems have been shown to have a heritable component of moderate size. Previous molecular genetic studies on sexual desire have mainly focused on genes associated with neurotransmitters such as dopamine and serotonin. Nevertheless, there is reason to believe that hormones with more specific functions concerning sexuality could have an impact on sexual desire and arousal.
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| 2. |
- Jern, Patrick, et al.
(författare)
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A Study of Possible Associations Between Single Nucleotide Polymorphisms in the Serotonin Receptor 1A, 1B, and 2C Genes and Self-Reported Ejaculation Latency Time
- 2012
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Ingår i: The Journal of Sexual Medicine. - : Oxford University Press (OUP). - 1743-6109 .- 1743-6095. ; 9:3, s. 866-872
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Tidskriftsartikel (refereegranskat)abstract
- Introduction. Previous research has indicated that serotonergic genes may influence ejaculatory function. Attempts to investigate effects of polymorphisms in serotonergic genes have been carried out, but so far, no study has conducted exploratory genotype analyses regarding the serotonin receptor 1A, 1B, and 2C subtypes, which have been hypothesized to mediate the inhibitory effects of serotonin on ejaculation in rodents. Aim. The aim of the present study was to investigate effects of a total of six single nucleotide polymorphisms (SNPs) located in genes encoding serotonin receptor subtypes 1A, 1B, and 2C on self-reported ejaculation latency time. Methods. A retrospective self-report measure of ejaculation latency time was used to investigate ejaculatory function in a population-based sample of 1,399 male twins. DNA was collected using self-administered saliva sampling. Main Outcome Measure. Calculations of allelic effects were conducted using the Generalized Estimating Equations module of PASW 18.0, which appropriately controls for between-subjects dependence. Results. Out of six investigated polymorphisms, two SNPs (both serotonin receptor 5-HT(1B) linked) had a significant main effect on ejaculation latency time. Of these, one (rs11568817) remained significant after Bonferroni correction for multiple testing, indicating that individuals homozygous for the G allele had significantly shorter ejaculation latencies. Conclusions. The results of this study support the hypothesis that serotonergic genes play a role in ejaculatory function in the general population. Replication of the results of the present study is warranted. Jern P, Westberg L, Johansson A, Gunst A, Eriksson E, Sandnabba K, and Santtila P. A study of possible associations between single nucleotide polymorphisms in the serotonin receptor 1A, 1B, and 2C genes and self-reported ejaculation latency time. J Sex Med **;**:**-**.
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| 3. |
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| 4. |
- Jern, Patrick, et al.
(författare)
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Using Ecological Momentary Assessment to Investigate Associations between Ejaculatory Latency and Control in Partnered and Non-Partnered Sexual Activities.
- 2011
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Ingår i: Journal of sex research. - : Informa UK Limited. - 1559-8519 .- 0022-4499. ; 48:4, s. 316-324
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Tidskriftsartikel (refereegranskat)abstract
- Ecological Momentary Assessment (EMA) was used to investigate associations between, and variations in, ejaculatory control and ejaculation latency time (ELT) over repeated measurements of sexual activities. Differences between measures recorded in partnered or non-partnered settings were also investigated. The sample consisted of 21 male Finns aged 18 years or above, contributing a total of 158 reports of partnered and non-partnered sexual activities over a six-week period. In the context of non-partnered sexual activities, after controlling for within-subjects dependence, ELTs between events were predictive of one another, but ELT did not predict ejaculatory control when measured simultaneously, nor at subsequent events. Also, ejaculatory control could not predict simultaneously measured ELT or ejaculatory control at subsequent events. During partnered sexual activities, both ejaculatory control and ELT could be accurately predicted by observing ejaculatory control at prior events. In this context, ejaculatory control could also reliably predict simultaneously measured ELT. ELT or ejaculatory control during partnered sexual activity could not be predicted by observing ELT at prior events. Between-event correlations were generally low, indicating considerable variation in ejaculatory functioning over time. EMA is a thrifty assessment method for studying variations in ejaculatory function, and is likely suitable for studying sexual dysfunctions in general.
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| 5. |
- Sandnabba, N. Kenneth, et al.
(författare)
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Sexuella komponenter bakom brott
- 2008
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Ingår i: Handbok i rättspsykologi. - : Liber, Stockholm. - 9789147052875
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- This chapter discusses a number of central topicts related to sexual behaviour and sexual crimes. Among the themes discussed are, attitudes and the law concerning sexual behaviour; diagnostic aspects; sexual criminals as a heterogenous group; motives behind sexual assualts and rape; deviant sexual behaviour/ paraphilias (e.g., exhibitionism, pedophilia, arson, lust murder) and female sex offenders. Pro and cons associated with different lineup procedures are discussed. The chapter also decribes psychological autopsy as an investigative aid in sexual crimes.
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| 6. |
- Santtila, Pekka, et al.
(författare)
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The Dopamine Transporter Gene (DAT1) Polymorphism is Associated with Premature Ejaculation.
- 2010
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Ingår i: The journal of sexual medicine. - : Oxford University Press (OUP). - 1743-6109 .- 1743-6095. ; 7:4 pt1, s. 1538-1546
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Tidskriftsartikel (refereegranskat)abstract
- ABSTRACT Introduction. Previous research has suggested brain dopamine (DA) neurotransmission to be involved in the control of ejaculation. Furthermore, previous studies indicate a partly hereditary background to premature ejaculation. Aim. To investigate whether the dopamine transporter gene (DAT1) polymorphism is associated with premature ejaculation. Methods. Retrospective self-reports of four indicators reflecting ejaculatory function-anteportal ejaculation, number of penile thrusts, ejaculation latency time, and feeling of control over ejaculation-and saliva samples for DNA analysis were obtained from 1,290 men (M = 26.9, standard deviation = 4.7 years; range 18-45) with sexual experience. Main Outcome Measures. Calculations of allelic effects were computed using the Generalized Estimating Equations module of SPSS 17. Results. Carriers of the 10R10R genotype had scores indicating a lower threshold to ejaculate on each of the indicators compared to the combined 9R9R/9R10R carrier group. The differences were significant both for the composite score and for anteportal ejaculation, number of thrusts, and feeling of control over ejaculation, but not for ejaculation latency time. The effect of the polymorphism remained significant after controlling for age, homosexual experience, having a regular sexual partner, level of sexual desire, and frequency of sexual activity, hence suggesting that it is not secondary to an association between the studied polymorphism and some other aspect of sexual behavior, but due to a specific influence of DA on ejaculation. Conclusions. The findings of the present study support results of previous studies indicating involvement of dopaminergic neurotransmission in ejaculation. Santtila P, Jern P, Westberg L, Walum H, Pedersen CT, Eriksson E, and Sandnabba NK. The dopamine transporter gene (DAT1) polymorphism is associated with premature ejaculation. J Sex Med **;**:**-**.
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| 7. |
- Suchankova, Petra, 1979, et al.
(författare)
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Genetic variation of the growth hormone secretagogue receptor gene is associated with alcohol use disorders identification test scores and smoking
- 2016
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Ingår i: Addiction Biology. - : Wiley. - 1355-6215 .- 1369-1600. ; 21:2, s. 481-488
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Tidskriftsartikel (refereegranskat)abstract
- The multifaceted gut-brain peptide ghrelin and its receptor (GHSR-1a) are implicated in mechanisms regulating not only the energy balance but also the reward circuitry. In our pre-clinical models, we have shown that ghrelin increases whereas GHSR-1a antagonists decrease alcohol consumption and the motivation to consume alcohol in rodents. Moreover, ghrelin signaling is required for the rewarding properties of addictive drugs including alcohol and nicotine in rodents. Given the hereditary component underlying addictive behaviors and disorders, we sought to investigate whether single nucleotide polymorphisms (SNPs) located in the pre-proghrelin gene (GHRL) and GHSR-1a gene (GHSR) are associated with alcohol use, measured by the alcohol use disorders identification test (AUDIT) and smoking. Two SNPs located in GHRL, rs4684677 (Gln90Leu) and rs696217 (Leu72Met), and one in GHSR, rs2948694, were genotyped in a subset (n = 4161) of a Finnish population-based cohort, the Genetics of Sexuality and Aggression project. The effect of these SNPs on AUDIT scores and smoking was investigated using linear and logistic regressions, respectively. We found that the minor allele of the rs2948694 SNP was nominally associated with higher AUDIT scores (P = 0.0204, recessive model) and smoking (P = 0.0002, dominant model). Furthermore, post hoc analyses showed that this risk allele was also associated with increased likelihood of having high level of alcohol problems as determined by AUDIT scores ≥ 16 (P = 0.0043, recessive model). These convergent findings lend further support for the hypothesized involvement of ghrelin signaling in addictive disorders.
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