| 1. |
- Bjelke, Ulf, et al.
(författare)
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Crustacea : Kräftdjur - crustaceans
- 2010
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Ingår i: The 2010 Red List of Swedish Species. Rödlistade arter i Sverige 2010. - Uppsala : ArtDatabanken, SLU. - 9789188506351 ; , s. 487-493
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Bokkapitel (övrigt vetenskapligt/konstnärligt)
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| 2. |
- Hidemark, Ove, et al.
(författare)
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Nygotiska kyrkor i Skåne : utveckling i form, material och konstruktion 1840-1910
- 1991
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Bok (populärvet., debatt m.m.)abstract
- Denna bok har sin utgångspunkt i 1981/82 års studier i skånskt 1800-talsbyggande där Arkitekturskolans restaureringslinje valde att ägna sitt intresse åt det relativt obeaktade bestånd av nygotiska kyrkor som Skåne erbjuder. Studiernas syfte har varit attförsöka fånga kyrkornas specifika såväl estetiska som tekniska karaktäristiska och beskriva den utveckling som de representerar.
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| 3. |
- Horstkotte, Tim, 1981-, et al.
(författare)
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Pastures under pressure : Effects of other land users and the environment
- 2022
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Ingår i: Reindeer Husbandry and Global Environmental Change. - London : Routledge. - 9781000593402 - 9780367632670 ; , s. 76-98
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Bokkapitel (refereegranskat)abstract
- Reindeer husbandry has a long history of sharing landscapes with a multitude of other forms of land use. By competing for space, industrial resource developments from the early 20th century onwards have affected where, when and how the landscape can be used for reindeer grazing. Extending from the local to the landscape level, these impacts can reduce pastures either directly or indirectly as a result of increasing landscape fragmentation or changing reindeer behaviour. Furthermore, environmental drivers influence the dynamics of forage availability or accessibility for reindeer. The observed trend of shrinking pastures in the three countries is caused by these cumulative impacts. As a consequence, grazing pressure on the remaining pastures increases, and it curtails reindeer herders’ options to respond to the challenges of climate change. Reversing the continuing decrease in pastures requires the restoration of grazing resources and increasing landscape connectivity to facilitate movement and grazing rotation. However, socio-political incentives are also required to sustain reindeer pastures in the future. This includes an increase in the influence of reindeer herders on land use decisions and the inclusion of their traditional ecological knowledge of pasture management to identify alternative approaches to natural resource management.
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| 4. |
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| 5. |
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| 6. |
- Björnsson, Bergthor, et al.
(författare)
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Nitrite, a novel method to decrease ischemia/reperfusion injury in the rat liver
- 2015
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Ingår i: World Journal of Gastroenterology. - : Baishideng Publishing Group Co. Limited. - 1007-9327 .- 2219-2840. ; 21:6, s. 1775-1783
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Tidskriftsartikel (refereegranskat)abstract
- AIM: To investigate whether nitrite administered prior to ischemia/reperfusion (I/R) reduces liver injury.METHODS: Thirty-six male Sprague-Dawley rats were randomized to 3 groups, including sham operated (n = 8), 45-min segmental ischemia of the left liver lobe (IR, n = 14) and ischemia/reperfusion (I/R) preceded by the administration of 480 nmol of nitrite (n = 14). Serum transaminases were measured after 4 h of reperfusion. Liver microdialysate (MD) was sampled in 30-min intervals and analyzed for glucose, lactate, pyruvate and glycerol as well as the total nitrite and nitrate (NOx). The NOx was measured in serum.RESULTS: Aspartate aminotransferase (AST) at the end of reperfusion was higher in the IR group than in the nitrite group (40 ± 6.8 μkat/L vs 22 ± 2.6 μkat/L, P = 0.022). Similarly, alanine aminotransferase (ALT) was also higher in the I/R group than in the nitrite group (34 ± 6 μkat vs 14 ± 1.5 μkat, P = 0.0045). The NOx in MD was significantly higher in the nitrite group than in the I/R group (10.1 ± 2.9 μM vs 3.2 ± 0.9 μM, P = 0.031) after the administration of nitrite. During ischemia, the levels decreased in both groups and then increased again during reperfusion. At the end of reperfusion, there was a tendency towards a higher NOx in the I/R group than in the nitrite group (11.6 ± 0.7 μM vs 9.2 ± 1.1 μM, P = 0.067). Lactate in MD was significantly higher in the IR group than in the nitrite group (3.37 ± 0.18 mM vs 2.8 ± 0.12 mM, P = 0.01) during ischemia and the first 30 min of reperfusion. During the same period, glycerol was also higher in the IRI group than in the nitrite group (464 ± 38 μM vs 367 ± 31 μM, P = 0.049). With respect to histology, there were more signs of tissue damage in the I/R group than in the nitrite group, and 29% of the animals in the I/R group exhibited necrosis compared with none in the nitrite group. Inducible nitric oxide synthase (iNOS) transcription increased between early ischemia (t = 15) and the end of reperfusion in both groups.CONCLUSION: Nitrite administered before liver ischemia in the rat liver reduces anaerobic metabolism and cell necrosis, which could be important in the clinical setting.
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| 7. |
- Björnsson, Bergthor, et al.
(författare)
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Remote or Conventional Ischemic Preconditioning -Local Liver Metabolism in Rats Studied with Microdialysis
- 2012
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Ingår i: Journal of Surgical Research. - : Elsevier. - 0022-4804 .- 1095-8673. ; 176:1, s. 55-62
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Tidskriftsartikel (refereegranskat)abstract
- Background. Ischemic preconditioning (IPC) of the liver decreases liver injury secondary to ischemia and reperfusion. An attractive alternative to IPC is remote ischemic preconditioning (R-IPC), but these two methods have not previously been compared. Material and Methods. Eighty-seven rats were randomized into four groups: sham operated (n = 15), 1 h segmental ischemia (IRI, n = 24), preceeded by IPC (n = 24), or R-IPC (n = 24) (to the left hindleg). IPC and R-IPC were performed with 10 min ischemia and 10 min of reperfusion. Analyses of liver microdialysate (MD), serum transaminase levels, and liver histology were made. Results. Rats treated with IPC and R-IPC had significantly lower AST, 71.5 (19.6) IU/L respective 96.6 (12.4) at 4 h reperfusion than those subjected to IRI alone, 155 (20.9), P = 0.0004 and P = 0.04 respectively. IPC also had lower ALT levels, 41.6 (11.3) IU/L than had IRI 107.4 (15.5), P = 0.003. The MD glycerol was significantly higher during ischemia in the R-IPC = 759 (84) mu M] and the IRI = 732 (67)] groups than in the IPC 514 (70) group, P = 0.022 and P = 0.046 respectively. The MD glucose after ischemia was lower in the IPC group 7.1 (1.2) than in the IRI group 12.7 (1.6), P = 0.005. Preconditioning to the liver caused an direct increase in lactate, glucose and glycerol in the ischemic segment compared with the control segment an effect not seen in the R-IPC and IRI groups. Conclusions. IPC affects glucose metabolism in the rat liver, observed with MD. IPC reduces liver cell injury during ischemic and reperfusion in rats. R-IPC performed over the same length of time as IPC does not have the same effect as the latter on ALT levels and MD glycerol; this may suggest that R-IPC does not offer the same protection as IPC in this setting of rat liver IRI.
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| 8. |
- Bojmar, Linda, et al.
(författare)
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miR-18a is regulated between progressive compartments of cancers, and incorporated in exosomes with the potential of creating premetastatic niches and predict cancer outcome
- 2015
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Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- The ultimate cause of death for many cancer patients is the spread of the cancer via metastasis. Even so, there are still a lack of knowledge regarding the metastasis process. This study was performed to investigate the role of metastamirs in exosomes and their metastatic patterns. We used the well-established isogeneic murine cancer model of low metastatic 67NR cells, mimicking luminal/basal breast tumors, and highly metastatic 4T1 cells with characteristics of basal breast tumors. We studied the exosomal properties and pre-metastatic effects in this metastasis model and compared human materials and exosomes of several other tumor types. Our data clearly demonstrated that exosomes from the highly metastatic cells home to the metastatic organs of their parental cells whereas exosomes from cells with low metastatic potential mostly located to lymph nodes. The exosome protein cargos also resembled their parental cells and potentially affects their target organs, and cells, differently. Furthermore, the exosomes from the highly metastatic cells had a more pronounced effect on tumor growth and pre-metastatic changes than the low metastatic exosomes. The microRNA-18a, a predictor of metastasis, was present to a higher extent in metastatic exosomes as compared to low metastatic exosomes, and altered the tumor progressive properties. Our findings support the role of exomirs as important players in the metastatic process, the value as biomarkers and potential therapeutic targets.
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| 9. |
- Bojmar, Linda, et al.
(författare)
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The Role of MicroRNA-200 in Progression of Human Colorectal and Breast Cancer
- 2013
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Ingår i: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 8:12, s. 84815-
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Tidskriftsartikel (refereegranskat)abstract
- The role of the epithelial-mesenchymal transition (EMT) in cancer has been studied extensively in vitro, but involvement of the EMT in tumorigenesis in vivo is largely unknown. We investigated the potential of microRNAs as clinical markers and analyzed participation of the EMT-associated microRNA-200 ZEB E-cadherin pathway in cancer progression. Expression of the microRNA-200 family was quantified by real-time RT-PCR analysis of fresh-frozen and microdissected formalin-fixed paraffin-embedded primary colorectal tumors, normal colon mucosa, and matched liver metastases. MicroRNA expression was validated by in situ hybridization and after in vitro culture of the malignant cells. To assess EMT as a predictive marker, factors considered relevant in colorectal cancer were investigated in 98 primary breast tumors from a treatment-randomized study. Associations between the studied EMTmarkers were found in primary breast tumors and in colorectal liver metastases. MicroRNA-200 expression in epithelial cells was lower in malignant mucosa than in normal mucosa, and was also decreased in metastatic compared to non-metastatic colorectal cancer. Low microRNA-200 expression in colorectal liver metastases was associated with bad prognosis. In breast cancer, low levels of microRNA-200 were related to reduced survival and high expression of microRNA-200 was predictive of benefit from radiotheraphy. MicroRNA-200 was associated with ER positive status, and inversely correlated to HER2 and overactivation of the PI3K/AKT pathway, that was associated with high ZEB1 mRNA expression. Our findings suggest that the stability of microRNAs makes them suitable as clinical markers and that the EMT-related microRNA-200 - ZEB - E-cadherin signaling pathway is connected to established clinical characteristics and can give useful prognostic and treatment-predictive information in progressive breast and colorectal cancers.
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| 10. |
- Branström, J., et al.
(författare)
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Compression wood in knots and the effect on surface roughness.
- 2005
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Ingår i: proceedings from IMPC 2005.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The microstructural and ultrastructural characteristics of knot wood were examined and related to paper properties. Norway spruce (Picea abies) chips were laboratory fractionated and sorted into a knot containing assortment and a non knot containing reference assortment. The proportions of compression wood in these two assortments were then assessed and the two chip assortments refined in pilot refiners. The knot containing portion was divided into wood from the upper branch, wood from the lower branch compression wood and wood surrounding the branch. Fibres from the three knotwood portions and the reference chips were extracted and measurements were made of fibre properties including fibre length, fibre width and cell wall thickness. The two chip assortments were refined in a pilot plant and the surface properties of laboratory sheets were measured. The knot containing chips had adverse effects on several paper properties. However, no clear relationship was established between surface roughness and the presence of compression wood fibres in knot wood. (6 fig, 12 ref)
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