| 1. |
- Argenbright, Christine, et al.
(författare)
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Embracing diversity : measuring the impact of an international immersion learning experience on nursing students' cultural beliefs and values
- 2022
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Ingår i: International Journal of Nursing Education Scholarship. - : Walter de Gruyter. - 1548-923X .- 2194-5772. ; 19:1
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: An international Nursing Leadership Collaborative covened in Japan to hold a patient safety and quality workshop for nursing students from six countries. The purpose was to measure students' self reported beliefs reflecting sensitivity and openness to cultural diversity before and after the international experience.METHODS: A pre-post-test design was used and the Beliefs, Events, and Values Inventory was administered to international undergraduate and graduate nursing students.RESULTS: The group aggregate data analysis indicate that prior to the start of the workshop, the group presented itself as quite introspective and after the workshop the group reported being more sophisticated in making causal explanations about why the world works in the way it does.CONCLUSIONS: Nursing students experienced an expanded awareness of their beliefs and values that reflect a greater degree of intercultural sensitivity for acceptance of inclusivity and diversity after the experience.
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| 2. |
- Argenbright, Christine, et al.
(författare)
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Making a Difference : Changing Nursing Students’ Global Beliefs
- 2018
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Background: In August of 2017, the Nursing Leadership Collaborative of the International Network of Universities (INU), convened in Hiroshima, Japan to hold a patient safety and quality of care workshop for nursing students from six INU universities located in Japan, Spain, Sweden, South Africa, United Kingdom and the United States. The workshop, held during Peace Week, had as its purpose to develop a model of international collaboration and education to impact quality and safety education in nursing. In addition to examining the impact of the experience on student learning, the leaders wished to determine to what degree students’ beliefs and values changed due to participation in the nursing collaborative workshop. The purpose of this research was to measure students’ self-reported beliefs that reflect global competency and openness to cultural diversity. Methods: IRB approval was obtained and a pre-post-test mixed method design was used with the convenience sample of 21 English speaking international undergraduate and graduate nursing students. The workshop lasted 9 days and included a curriculum based on the Quality and Safety Education for Nurses (QSEN) Competencies. Experiential clinical activities focused on how patient safety is improved in Japan. Cultural activities were integrated and primarily focused on the Peace Week events which included the Peace Day ceremony to memorialize the dropping of the atomic bomb on Hiroshima. The Beliefs, Events, and Values Inventory (BEVI), a mixed methods measure, was administered and used to asses relevant processes and constructs including (but not limited to); openness; receptivity to different cultures; stereotyping; self and emotional awareness; and strategies for making sense of why people do what they do. (Shealy, 2017). This study examines Time 1 (prior to participation in the program) and Time 2 (immediately after the completion of the program). Students also completed daily reflections in response to prompts provided by faculty. Qualitative data analysis was completed using NVivo software. Results: Results from the group aggregate data analysis indicate that prior to the start of the program (Time 1) this group presents itself as quite introspective (Self-awareness = 75thpercentile); midway between confident and inquisitive in terms of understanding who others are, how world works, and their experience of life (Basic Determinism = 41st percentile); quite open to and interested in cultural beliefs and practices that are different from one’s own (Sociocultural Openness = 74th percentile); open to non-traditional gender roles (Gender Traditionalism = 20th percentile); do not have strong religious convictions (Religious Traditionalism = 26th percentile); and express a high degree of concern about ecological issues and the natural world (Ecological Resonance = 59th percentile). Following the completion of the program (Time 2), the group as a whole reported being more sophisticated in making causal explanations about why the world works in the way it does (Basic Determinism = 30th percentile); increased openness to and interest in cultural beliefs and practices that are different from one’s own (Sociocultural Openness = 80th percentile); increased openness to non-traditional gender roles (Gender Traditionalism = 13th percentile); further decrease in strong religious convictions (Religious Traditionalism = 20th percentile); and increased degree of concern about ecological issues and the natural world (Ecological Resonance = 71stpercentile). Statements from qualitative data analysis reflect greater understanding and empathy for others’ perspectives and experiences and increased openness. Conclusion: Nursing students experienced changes in their beliefs and values that reflect a greater degree of global competency after the short term international workshop experience with other nursing students.
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| 3. |
- Bengtsson, Mariette, et al.
(författare)
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Göra skillnad : förändra sjuksköterskestudenters kliniska och globala kompetens
- 2018
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Bakgrund: I augusti 2017 genomförde Nursing Leadership Collaborative of the International Network of Universities (INU) en workshop i Hiroshima, Japan med temat Patient Safety and Quality Care. Workshoppen som varade i nio dagar avsåg att utveckla en modell för internationellt samarbete och utbildning i syfte att stärka patientsäkerhet och kvalitetsförbättringsfrågor utifrån ett globalt perspektiv. Utbildningen baserades på ett koncept utarbetat inom ramen för The Quality and Safety Education for Nurses (QSEN) som utgick från sjuksköterskans kärnkompetenser. Undervisningen i form av teori, praktik och studiebesök, varvades med kulturella aktiviteter som bland annat inkluderade fredsceremoni till minne av atombomben som släpptes över Hiroshima den 4 augusti 1945, ”The A-bomb day”. Undervisningen leddes av INU medlemmar som alla är experter i ämnet Syftet med workshopen och tillhörande utvärdering och forskning var att undersöka om sjuksköterskestudenters kliniska kompetens ökar genom att delta i internationell workshop samt om deras självrapporterade övertygelser som speglar global kompetens och öppenhet mot kulturell mångfald förändrades. Det är viktigt att värdera resultat och effekter av all undervisning och lärande, speciellt internationella projekt som genererar fler resurser än traditionell undervisning på hemma universitetet. Metod: Deltagare i workshopen var 21 sjuksköterskestudenter från sex INU-anslutna universitet, Japan, Spanien, Sverige, Syd Afrika, Storbritannien och USA. Innan workshopen började och i anslutning till att workshopen avslutades svarade studenterna på olika kunskapsfrågor på innehåll som togs upp under workshopen (för- och eftertest). Studenterna svarade också på enkäten Beliefs, Events, and Values Inventory (BEVI) vid samma tillfälle samt 6 månader senare. Studenterna skrev även dagliga reflektioner kring undervisningen och sina övriga upplevelser. Analys baserad på denna kvalitativ data kommer att genomföras med stöd av NVivo-programvara. Resultat: All data har ännu inte analyserats men preliminära resultat visar på att sjuksköterskestudenterna hade förbättrat sin kliniska kompetens kring patientsäkerhet och förbättringsarbete efter att ha deltagit i workshopen. Resultatet speglar en större förståelse och empati för andras perspektiv och erfarenheter och ökad öppenhet mot andra synsätt och kulturer. Som grupp visade analysen av BEVI på att deltagarna hade skaffat sig en ökad förståelse för varför världen fungerar på det sätt som den gör och deras var bekymmer för ekologiska världsproblem hade ökat. Resultatet visade även på en ökad öppenhet mot och intresse för andra kulturella övertygelser och praxis som skiljer sig från sin egen sociokulturell miljö och på en ökad öppenhet gentemot icke-traditionella könsroller. Arbetet med den internationella kursen var en utmaning även om det fanns en samsyn om innehållet. Det fanns kulturella skillnader avseende pedagogik och arbetssätt. Slutsats: Förutom att öka sin kliniska kompetens genom att delta i en internationell workshop upplevde sjuksköterskestudenterna förändringar i sina övertygelser och värderingar som speglar en större grad av global kompetens. Detta är en viktig kompetens för det livslånga lärandet i dagens och morgondagens mångfaldssamhälle oavsett om studenten praktiserar sitt yrke på hemorten eller i ett nationellt sammanhang. Internationella sammarbeten främjar också lärarens pedagogiska kompetens.
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| 4. |
- Chen, Zhishan, et al.
(författare)
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Fine-mapping analysis including over 254 000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
- 2024
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
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Tidskriftsartikel (refereegranskat)abstract
- Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases and 154,587 controls of East Asian and European ancestry. Our stepwise conditional analyses revealed 238 independent association signals of CRC risk, each with a set of credible causal variants (CCVs), of which 28 signals had a single CCV. Our cis-eQTL/mQTL and colocalization analyses using colorectal tissue-specific transcriptome and methylome data separately from 1299 and 321 individuals, along with functional genomic investigation, uncovered 136 putative CRC susceptibility genes, including 56 genes not previously reported. Analyses of single-cell RNA-seq data from colorectal tissues revealed 17 putative CRC susceptibility genes with distinct expression patterns in specific cell types. Analyses of whole exome sequencing data provided additional support for several target genes identified in this study as CRC susceptibility genes. Enrichment analyses of the 136 genes uncover pathways not previously linked to CRC risk. Our study substantially expanded association signals for CRC and provided additional insight into the biological mechanisms underlying CRC development.
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| 5. |
- Fernandez-Rozadilla, Ceres, et al.
(författare)
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Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries
- 2023
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 55, s. 89-99
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Tidskriftsartikel (refereegranskat)abstract
- Colorectal cancer (CRC) is a leading cause of mortality worldwide. We conducted a genome-wide association study meta-analysis of 100,204 CRC cases and 154,587 controls of European and east Asian ancestry, identifying 205 independent risk associations, of which 50 were unreported. We performed integrative genomic, transcriptomic and methylomic analyses across large bowel mucosa and other tissues. Transcriptome- and methylome-wide association studies revealed an additional 53 risk associations. We identified 155 high-confidence effector genes functionally linked to CRC risk, many of which had no previously established role in CRC. These have multiple different functions and specifically indicate that variation in normal colorectal homeostasis, proliferation, cell adhesion, migration, immunity and microbial interactions determines CRC risk. Crosstissue analyses indicated that over a third of effector genes most probably act outside the colonic mucosa. Our findings provide insights into colorectal oncogenesis and highlight potential targets across tissues for new CRC treatment and chemoprevention strategies.
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| 6. |
- Mikhail, Fady M., et al.
(författare)
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Overlapping phenotype of wolf-hirschhorn and beckwith-wiedemann syndromes in a girl with der(4)t(4; 1 1)(pter;pter)
- 2007
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Ingår i: American Journal of Medical Genetics, Part A. - : Wiley. - 1552-4825 .- 1552-4833. ; 143:15, s. 1760-1766
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Tidskriftsartikel (refereegranskat)abstract
- We report on an 8-month-old girl with a novel unbalanced chromosomal rearrangement, consisting of a terminal deletion of 4p and a paternal duplication of terminal 11p. Each of these is associated with the well-known clinical phenotypes of Wolf-Hirschhorn syndrome (WHS) and Beckwith-Wiedemann syndrome (BWS), respectively. She presented for clinical evaluation of dysmorphic facial features, developmental delay, atrial septal defect (ASD), and left hydro-nephrosis. High-resolution cytogenetic analysis revealed a normal female karyotype, but subtelomeric fluorescence in situ hybridization (FISH) analysis revealed a der(4)t(4;11) (pter;pter). Both FISH and microarray CGH studies clearly demonstrated that the WHS critical regions 1 and 2 were deleted, and that the BWS imprinted domains (ID) 1 and 2 were duplicated on the der(4). Parental chromosome analysis revealed that the father carried a cryptic balanced t(4;11)(pter;pter). As expected, our patient manifests findings of both WHS (a growth retardation syndrome) and BWS (an overgrowth syndrome). We compare her unique phenotypic features with those that have been reported for both syndromes.
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| 7. |
- Sanford, Julie, et al.
(författare)
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Student outcomes of an international learning collaborative to develop patient safety and quality competencies in nursing
- 2021
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Ingår i: Journal of Research in Nursing. - : Sage Publications. - 1744-9871 .- 1744-988X. ; 26:1-2, s. 81-94
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Tidskriftsartikel (refereegranskat)abstract
- Background: Patient harm is a global crisis fueling negative outcomes for patients around the world. Working together in an international learning collaborative fostered learning with, from and about each other to develop evidence-based strategies for developing quality and safety competencies in nursing.Aims: To report student outcomes from an international learning collaborative focused on patient safety using the Quality and Safety Education for Nurses competency framework.Methods: A global consortium of nursing faculty created an international learning collaborative and designed educational strategies for an online pre-workshop and a 10-day in-person experience for 21 undergraduate and graduate nursing students from six countries. A retrospective pre-test post-test survey measured participants' confidence levels of patient safety competence using the health professional education in patient safety survey and content analysis of daily reflective writings.Results: Statistical analysis revealed student confidence levels improved across all eight areas of safe practice comparing-pre and post-education (significance, alpha of P < 0.05). Two overarching themes, reactions to shared learning experiences and shared areas of learning and development, reflected Quality and Safety Education for Nurses competencies and a new cultural understanding.Conclusions: The international learning collaborative demonstrated that cross-border learning opportunities can foster global development of quality and safety outcome goals.
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