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Sökning: WFRF:(Sankar Sathish)

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1.
  • Selvavinayagam, Sivaprakasam T., et al. (författare)
  • Genomic surveillance of omicron B.1.1.529 SARS‐CoV‐2 and its variants between December 2021 and March 2023 in Tamil Nadu, India—A state‐wide prospective longitudinal study
  • 2024
  • Ingår i: Journal of Medical Virology. - : John Wiley & Sons. - 0146-6615 .- 1096-9071. ; 96:2
  • Tidskriftsartikel (refereegranskat)abstract
    • A state-wide prospective longitudinal investigation of the genomic surveillance of the omicron B.1.1.529 SARS-CoV-2 variant and its sublineages in Tamil Nadu, India, was conducted between December 2021 and March 2023. The study aimed to elucidate their mutational patterns and their genetic interrelationship in the Indian population. The study identified several unique mutations at different time-points, which likely could attribute to the changing disease characteristics, transmission, and pathogenicity attributes of omicron variants. The study found that the omicron variant is highly competent in its mutating potentials, and that it continues to evolve in the general population, likely escaping from natural as well as vaccine-induced immune responses. Our findings suggest that continuous surveillance of viral variants at the global scenario is warranted to undertake intervention measures against potentially precarious SARS-CoV-2 variants and their evolution.
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2.
  • Vignesh, Ramachandran, et al. (författare)
  • Gut Microbiota Peculiarities in Aged HIV-Infected Individuals : Molecular Understanding and Therapeutic Perspectives
  • 2023
  • Ingår i: Gut Microbiota in Aging and Chronic Diseases. - Cham : Springer. - 9783031140228 - 9783031140235 ; , s. 415-439
  • Bokkapitel (refereegranskat)abstract
    • Aging is a progressive physiological process that involves alterations in the population of normal gutGut microbiotaGut microbiota. HIV infectionHIV infection in conjunction with agingAgeing complicates the quality of immune responses paving way for increased epithelial permeability and translocation of commensals and pathogen-derived substances into the systemic circulation. Enteric dysbiosisDysbiosis is linked with other comorbidities of agingAging including cardiovascular diseases and dementia in the HIV-infected population. The diversity of gutGut microbiotaGut microbiota declines with ageAge, and HIV infectionHIV infection compromises the effective functioning of the immune system complicating the metabolic as well as regulatory programming of the host’s physiological machinery. Given the scenario of the global HIV/AIDS and the COVID-19 pandemics, it is also likely that alterations in gutGut microbiotaGut microbiota potentially could contribute to post-acute COVID-19 syndrome as well as accelerate the rate of HIV disease progression. The current chapter discusses the role of normal gutGut microbiotaGut microbiota in the aged HIV-infected population and their functional implications in normal cellular and molecular mechanisms in the host.
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