| 1. |
- Adam, A, et al.
(författare)
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Abstracts from Hydrocephalus 2016.
- 2017
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Ingår i: Fluids and Barriers of the CNS. - : Springer Science and Business Media LLC. - 2045-8118. ; 14:Suppl 1
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Tidskriftsartikel (refereegranskat)
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| 4. |
- Husain, S., et al.
(författare)
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Large Dzyaloshinskii-Moriya interaction and atomic layer thickness dependence in a ferromagnet- WS2 heterostructure
- 2022
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Ingår i: Physical Review B. - : American Physical Society. - 2469-9950 .- 2469-9969. ; 105:6
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Tidskriftsartikel (refereegranskat)abstract
- Two-dimensional transition metal dichalcogenides (TMDs) have immense potential for spintronics applications. Here, we report atomic layer thickness dependence in WS2/Co3FeB heterostructures. The layer dependence is predicted by density functional theory and demonstrated experimentally by the layer dependence of the Dzyaloshinskii-Moriya interaction (DMI). Notably, we have observed the DMI in WS2 to be larger than that for heavy metals such as W and Ta, which is important to stabilize chiral structures. Inversion symmetry is not preserved with an odd number of layers, while it exists with an even number of layers. This symmetry rule is reflected in the temperature dependence of the effective damping parameter of the heterostructure. That the damping parameter decreases (increases) in odd (even) layers can be resolved at low temperature. This suggests that the layer dependence has its origin at the WS2 interface, where the spin-valley coupling and spin-orbit coupling activate these features. Large DMI, pure spin current, and unique layer dependence in TMDs provide valuable information and fundamental understanding for designing TMD-based quantum information storage devices. © 2022 American Physical Society.
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| 5. |
- Chattopadhyay, S., Pal, S., Pal, D., Sarkar, D., Chandra (Sanyal), S., DasGupta, C.
(författare)
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Protein folding in Escherichia coli: role of 23S ribosomal RNA
- 1999
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Ingår i: Biochim Biophys Acta. ; 1429:2, s. 293-8
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Tidskriftsartikel (refereegranskat)abstract
- Post-translational control of Escherichia coli ribosome on newly synthesised polypeptide leading to its active conformation (protein folding) has been shown in the case of the enzyme beta-galactosidase. As expected, antibiotics chloramphenicol and lincomy
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| 6. |
- Pal, S., Chandra (Sanyal), S., Chowdhury, S., Sarkar, D., Ghosh, A.N., DasGupta, C.
(författare)
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Complementary role of two fragments of domain V of 23 S ribosomal RNA in protein folding
- 1999
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Ingår i: J Biol Chem. ; 274:46, s. 32771-7
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Tidskriftsartikel (refereegranskat)abstract
- We have shown that the domain V of bacterial 23 S rRNA could fold denatured proteins to their active state. This segment of 23 S rRNA could further be split into two parts. One part containing mainly the central loop of domain V could bind denatured human
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| 9. |
- Siddiqui, Mohammad S., et al.
(författare)
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Differential fuel utilization in liver transplant recipients and its relationship with non-alcoholic fatty liver disease
- 2022
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Ingår i: Liver international (Print). - : Wiley. - 1478-3223 .- 1478-3231. ; 42:6, s. 1401-1409
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Tidskriftsartikel (refereegranskat)abstract
- Metabolic flexibility is the ability to match biofuel availability to utilization. Reduced metabolic flexibility, or lower fatty acid (FA) oxidation in the fasted state, is associated with obesity. The present study evaluated metabolic flexibility after liver transplantation (LT). Methods Patients receiving LT for non-alcoholic steatohepatitis (NASH) (n = 35) and non-NASH (n = 10) were enrolled. NASH was chosen as these patients are at the highest risk of metabolic complications. Metabolic flexibility was measured using whole-body calorimetry and expressed as respiratory quotient (RQ), which ranges from 0.7 (pure FA oxidation) to 1.0 is (carbohydrate oxidation). Results The two cohorts were similar except for a higher prevalence of obesity and diabetes in the NASH cohort. Post-prandially, RQ increased in both cohorts (i.e. greater carbohydrate utilization) but peak RQ and time at peak RQ was higher in the NASH cohort. Fasting RQ in NASH was significantly higher (0.845 vs. 0.772, p < .001), indicative of impaired FA utilization. In subgroup analysis of the NASH cohort, body mass index but not liver fat content (MRI-PDFF) was an independent predictor of fasting RQ. In NASH, fasting RQ inversely correlated with fat-free muscle volume and directly with visceral adipose tissue. Conclusion Reduced metabolic flexibility in patients transplanted for NASH cirrhosis may precede the development of non-alcoholic fatty liver disease after LT.
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| 10. |
- Zhu, Y., et al.
(författare)
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Proteogenomics produces comprehensive and highly accurate protein-coding gene annotation in a complete genome assembly of Malassezia sympodialis
- 2017
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Ingår i: Nucleic Acids Research. - : Oxford University Press. - 0305-1048 .- 1362-4962. ; 45:5, s. 2629-2643
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Tidskriftsartikel (refereegranskat)abstract
- Complete and accurate genome assembly and annotation is a crucial foundation for comparative and functional genomics. Despite this, few complete eukaryotic genomes are available, and genome annotation remains a major challenge. Here, we present a complete genome assembly of the skin commensal yeast Malassezia sympodialis and demonstrate how proteogenomics can substantially improve gene annotation. Through long-read DNA sequencing, we obtained a gap-free genome assembly for M. sympodialis (ATCC 42132), comprising eight nuclear and one mitochondrial chromosome. We also sequenced and assembled four M. sympodialis clinical isolates, and showed their value for understanding Malassezia reproduction by confirming four alternative allele combinations at the two mating-type loci. Importantly, we demonstrated how proteomics data could be readily integrated with transcriptomics data in standard annotation tools. This increased the number of annotated protein-coding genes by 14% (from 3612 to 4113), compared to using transcriptomics evidence alone. Manual curation further increased the number of protein-coding genes by 9% (to 4493). All of these genes have RNA-seq evidence and 87% were confirmed by proteomics. The M. sympodialis genome assembly and annotation presented here is at a quality yet achieved only for a few eukaryotic organisms, and constitutes an important reference for future host-microbe interaction studies.
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